Results 81 to 90 of about 1,620,419 (294)

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Primary Tonsillar Tuberculosis: Is it Really a Rare Entity?

Erciyes Medical Journal, 2020
Background: Oropharyngeal tuberculosis (TB), including tonsillar TB, is rare in an immunocompetent adult. Tonsillar TB is more likely to occur as a result of pulmonary TB causing secondary inoculation of tubercle bacilli. The primary form of tonsillar TB
Vinota Paniselvam, Chee Chean Lim, Fong Juen Kiew, Gagandeep Mann   +3 more
doaj   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

soft‐tissue infection in an immunocompetent child

, 2022
A previously healthy, fully immunised and immunocompetent 8-year-old child sustained a puncture wound to the dorsum of the left foot from a Bidens pilosa (cobbler's peg) plant while walking through the family's chicken coop.Full ...
Keith Grimwood, Beer, Jason, Alexis G Bosman, Grimwood, Keith, Bosman, Alexis G, Jason Beer   +5 more
core   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Cytomegalovirus ileitis in an immunocompetent elderly adult

, 2018
Cytomegalovirus enteritis is most usually associated with patients positive for human immunodeficiency virus or immunosuppressed transplant patients. The gastrointestinal tract may be affected anywhere from the esophagus to the colon, but the small bowel
이선영
core   +1 more source

Clinical case of parvovirus B19 infection in adult immunocompetent patient

Aktualʹnaâ Infektologiâ, 2018
A clinical case of parvovirus B19 infection is described. The published data on the development of parvovirus B19 infection in immunocompetent adult patients were analyzed in this article.
O.V. Markevych, O.V. Piddubna, V.O. Kuzmina   +2 more
doaj   +1 more source

An immunocompetent adult patient with hepatitis and guillain-barré syndrome after cytomegalovirus infection [PDF]

, 2011
Objectives It is to describe an immunocompetent adult patient with hepatitis and Guillain-Barré syndrome (GBS) after Cytomegalovirus (CMV) infection. In the initial course of the diagnosis and treatment, CMV infection was ignored.
Dou Xiao, Qi Ying, Feng Juan, Xiao Guang Dou, Ma Ying, Juan Feng, Ying Qi, Ying Ma, Xiao Dou   +8 more
core   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Look what’s eroding through the chest wall? Salmonella osteomyelitis of the ribs in an immunocompetent adult not associated with sickle cell disease

, 2010
We describe a case of Salmonella typhimurium osteomyelitis in an immunocompetent adult male patient without sickle cell disease. We are not aware of a previous report of this combination.
Rizwan Attia, Tom Routledge, Marco Scarci, Karen Harrison-Phipps   +3 more
core   +1 more source