Results 41 to 50 of about 138,294 (305)

Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions [PDF]

, 2016
Babesia microti, a tick-transmitted, intraerythrocytic protozoan parasite circulating mainly among small mammals, is the primary cause of human babesiosis.
Ben Mamoun, Choukri, Brancato, Jana, Chibucos, Marcus, Colinge, Jacques, Cornillot, Emmanuel, Crabtree, Jonathan, Dwivedi, Ankit, Fraser, Claire M., Frutos, Roger, Gotia, Hanzel T., Hung, Chris, Ifeonu, Olukemi O., Krause, Peter J., Kumar, Vidya, Kumari, Priti, Lawres, Lauren, McCracken, Carrie, Molina, Douglas M., Orvis, Joshua, Ott, Sandy, Pablo, Jozelyn V., Pazzi, Joseph E., Reynes, Christelle, Sadzewicz, Lisa, Sengamalay, Naomi, Shetty, Amol C., Silva, Joana C., Su, Qi, Tallon, Luke, Tretina, Kyle, Usmani-Brown, Sahar, Virji, Azan Z.   +31 more
core   +3 more sources

Disseminated Gastrointestinal Mucormycosis in Immunocompromised Disease [PDF]

Korean Journal of Critical Care Medicine, 2015
Mucormycosis is an uncommon opportunistic fungal infection mostly affecting immunocompromised patients and gastrointestinal mucormycosis is a rare and life-threatening.
Tae Sun Ha, Chi-Min Park, Jeong Hoon Yang, Yang Hyun Cho, Chi Ryang Chung, Kyeongman Jeon, Gee Young Suh   +6 more
doaj   +1 more source

Vomocytosis: Too Much Booze, Base, or Calcium? [PDF]

, 2019
Macrophages are well known for their phagocytic activity and their role in innate immune responses. Macrophages eat non-self particles, via a variety of mechanisms, and typically break down internalized cargo into small macromolecules.
Aaron, Alvarez, Alvarez, Artavanis-Tsakonas, Bain, Ben-Abdallah, Bielska, Blackstock, Boya, Bryan, Burch, Chang, Charlier, Chen, Cheng, Chu, Circu, Cox, Davis, De Leon-Rodriguez, De Leon-Rodriguez, Denham, Di, Diamond, Doshi, Dragotakes, Drew, Erb-Downward, Erwig, Evans, Feldmesser, Franchi, Fu, Gilbert, Gordon, Guerra, Gustafson, Haka, Han, Henson, Heo, Hibbs, Hoag, Hommel, Huang, Hybiske, Iwasaki, Johnston, Kjos, Kleinschek, Kruskal, Kusner, Lei, Leopold Wager, Levitz, Levitz, Lim, Liu, Lévêque, Ma, Maderna, May, Milam, Mosser, Murdock, Murray, Myers, Müller, Nel, Nicola, Nunes, Okagaki, O’Meara, Pauwels, Qiu, Rajasingham, Russell, Samantaray, Santiago-Tirado, Singh, Smith, Stukes, Stukes, Swisher, Tucker, Vashi, Voelz, Vu, Vu, Walkey, Wang, Wang, Watkins, Weiss, Wormley, Wozniak, Yates, Yoshida, Zaragoza   +98 more
core   +2 more sources

Endemic Mycoses in Immunocompromised Hosts [PDF]

Current Infectious Disease Reports, 2013
Endemic mycoses remain a significant cause of morbidity and mortality among immunocompromised patients. As the number of immunosuppressed individuals increases worldwide, the incidence of endemic mycoses is also expected to rise. In immunocompromised patients, endemic mycoses can present in atypical fashion, cause more severe and/or disseminated ...
Malcolm, Trent R, Chin-Hong, Peter V
openaire   +4 more sources

Bacteremia Secondary to Uncommon Gram-Negative Bacilli Transmitted From the Canine in a Patient With Multiple Myeloma

Journal of Investigative Medicine High Impact Case Reports, 2020
Sphingobacterium multivorum is a gram-negative rod found in the environment and rarely associated with human infections. Sphingobacterium is the causative agent of infections in an immunocompromised host in most cases. We report a rare case of cellulitis
Venu Madhav Konala MD, Srikanth Naramala MD, Subhashish Bose MD, Vijay Gayam MD, Bhaskar Reddy Madhira MD, Sreedhar Adapa MD   +5 more
doaj   +1 more source

Herpes simplex keratitis: Challenges in diagnosis and clinical management [PDF]

, 2017
Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a ...
Azher, Tayaba N, Huang, Andrew JW, Stuart, Patrick M, Tajfirouz, Deena, Yin, Xiao-Tang   +4 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Emerging Cutaneous Phaeohyphomycosis Caused by Alternaria infectoria

Acta Médica Portuguesa, 2021
Alternaria species belong to a group of opportunistic fungi that causes skin infection mainly in immunosuppressed patients. The authors describe two clinically distinct cases of cutaneous alternariosis caused by Alternaria infectoria in patients under ...
Katarína Kieselová, Tiago Gomes, Felicidade Santiago, Henrique Martinha   +3 more
doaj   +1 more source