Results 181 to 190 of about 8,578 (238)

Synthesis and Evaluation of Astatinated N-[2-(Maleimido)ethyl]-3-(trimethylstannyl)benzamide Immunoconjugates.

Bioconjugate chemistry, 2016
Effective treatment of metastasis is a great challenge in the treatment of different types of cancers. Targeted alpha therapy utilizes the short tissue range (50-100 μm) of α particles, making the method suitable for treatment of disseminated occult ...
Emma Aneheim, Anna Gustafsson, P. Albertsson, T. Bäck, H. Jensen, S. Palm, S. Svedhem, S. Lindegren   +7 more
semanticscholar   +2 more sources

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EGFR targeting for cancer therapy: Pharmacology and immunoconjugates with drugs and nanoparticles.

International journal of pharmaceutics, 2020
The epidermal growth factor receptor (EGFR) belongs to the tyrosine kinase receptors family and is present in the epithelial cell membrane. Its endogenous activation occurs through the binding of different endogenous ligands, including the epidermal ...
E. Santos, K. Nogueira, Luiziana Cavalcante Costa Fernandes, Jéssica Roberta Pereira Martins, A. Reis, José de Brito Vieira Neto, I. J. S. Júnior, C. Pessoa, R. Petrilli, J. Eloy   +9 more
semanticscholar   +1 more source

Immunoconjugates for cancer targeting: a review of antibody-drug conjugates and antibody-functionalized nanoparticles.

Current Medicinal Chemistry, 2020
Targeted therapy has been recently highlighted due to the reduction of side effects and improvement in overall efficacy and survival to different types of cancers.
R. Petrilli, D. Pinheiro, Fátima de Cássia Evangelista de Oliveira, Gabriela Fávero Galvão, Lana Grasiela Alves Marques, R. Lopez, C. Pessoa, J. Eloy   +7 more
semanticscholar   +1 more source

Immunoconjugates to increase photoinactivation of bovine alphaherpesvirus 1 in semen.

Veterinary Microbiology, 2020
Artificial insemination and in vitro embryo production are increasingly used to improve the reproductive efficiency of herds, however success of these techniques depends on the sanitary quality of the semen.
T. M. Oliveira, F. Bezerra, M. L. Gambarini, A. V. Teles, P. H. Cunha, Denize Silva Brazil, A. Ribeiro, P. Gonçalves, G. Souza   +8 more
semanticscholar   +1 more source

Steroid-Peptide Immunoconjugates for Attenuating T Cell Responses in an Experimental Autoimmune Encephalomyelitis Murine Model of Multiple Sclerosis.

Bioconjugate chemistry, 2020
Diseases of immunity, including autoimmune diseases such as multiple sclerosis, transplantation graft rejection, allergy, and asthma, are prevalent and increasing in prevalence.
R. Sands, I. Tabansky, Catia Verbeke, D. Keskin, S. Michel, Joel N.H. Stern, D. Mooney   +6 more
semanticscholar   +1 more source

Synthesis of an immunoconjugate of camptothecin

Bioorganic & Medicinal Chemistry Letters, 2002
The first immunoconjugate of camptothecin has been synthesized wherein the drug is attached to the tumor-recognizing antibody BR96 via a Cathepsin B cleavable linker. Endocytosis of the immunoconjugate upon binding to the tumor cell followed by enzymatic cleavage of the linker inside the endosome ensures tumor-specific release of the drug. In this way,
Michael A, Walker, Gene M, Dubowchik, Sandra J, Hofstead, Pamela A, Trail, Raymond A, Firestone   +4 more
openaire   +2 more sources

Bi-functional quantum dot-polysaccharide-antibody immunoconjugates for bioimaging and killing brain cancer cells in vitro

Materials letters (General ed.), 2019
The most common primary brain tumors in adults are gliomas, where glioblastoma multiforme is one of the deadliest in humans. In this study, we engineered novel nanoconjugates composed of Ag-In-S/ZnS quantum dots directly stabilized by chitosan ...
Cleildo P. Santana, A. Mansur, S. Carvalho, Armando Silva-Cunha, H. Mansur   +4 more
semanticscholar   +1 more source

Improved Targeting of Photosensitizers by Intratumoral Administration of Immunoconjugates

Technology in Cancer Research and Treatment, 2004
Biodistribution of technetium (99mTc) labeled hematoporphyrin derivative (HpD, Photosan-3) conjugated to a monoclonal antibody to carcinoembryonic antigen (anti-CEA) was compared following intravenous (i.v.) and intratumoral (i.t.) administration in ...
, Viney Jain
exaly   +2 more sources

Internalization of an intact doxorubicin immunoconjugate

Cancer Immunology, Immunotherapy, 1994
An immunoconjugate between doxorubicin and anti-(carcinoembryonic antigen) (CEA) was prepared by using aminodextran (M(r) = 40,000) as the intermediate carrier, and the carbohydrate moiety of the antibody as the linking site. The resulting immunoconjugate was subjected to an in vitro evaluation for the internalization on the target cells (Lo Vo), and ...
L B, Shih, D M, Goldenberg, H, Xuan, H W, Lu, M J, Mattes, T C, Hall   +5 more
openaire   +2 more sources

Nano‐Immunoconjugates in Immune Checkpoint Blockade: A Dual Approach to Precision Immunotherapy and Real‐Time Imaging

Asia-Pacific Journal of Clinical Oncology
Immune checkpoint blockade (ICB) therapies have revolutionized the treatment of cancer by harnessing the body's immune system to recognize and eradicate tumor cells. Despite clinical successes, the systemic administration of checkpoint inhibitors remains
Dilpreet Singh, Neena Bedi
semanticscholar   +1 more source