Results 91 to 100 of about 130,186 (296)

Differential expression and subcellular localization of BmHMGA in silkworm (Bombyx mori)

浙江大学学报. 农业与生命科学版, 2014
The high mobility group A (HMGA) proteins have a close relation with chromatin remodeling and cancer transformation. They are widely expressed during embryogenesis, whereas their expression is absent or very low in adult tissues.
Zhang Haihua, Zhao Yan, Zhang Hanming, Li Si, Quan Yanping, Yu Wei, Zhang Yaozhou, Tong Fudan, Zhang Xiaojuan   +8 more
doaj   +1 more source

Cytological Identification of a Rhabdoid Variant of Pancreatic Neuroendocrine Neoplasm. [PDF]

Cytopathology
Intracytoplasmic inclusions observed in rhabdoid‐type neuroendocrine tumours are evident on Giemsa staining and show strong cytokeratin (AE1/AE3) positivity on immunocytochemistry. This report describes the cytological features of a rare rhabdoid variant of pancreatic neuroendocrine neoplasm and highlights the diagnostic challenges associated with this
Okuda M, Mizuguchi K, Mori T, Okawa U, Ikeda H.   +4 more
europepmc   +2 more sources

Analysis of cytochrome c release by immunocytochemistry

, 2016
Cytochrome c is normally localized between the inner and outer membranes of mitochondria in healthy cells. However, during apoptosis, it is released into the cytoplasm, where it binds to apoptotic protease activating factor.
Crowley, Lisa C., Marfell, Brooke J., Scott, Adrian P., Waterhouse, Nigel J.   +3 more
core   +1 more source

Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions

Advanced Science, EarlyView.
Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park, Yunha Hwang, Jimin Kwak, Yuxi Lin, Hye‐Yeon Park, Eunju Nam, Jiyeon Han, Soyeon Park, Hyunyong Kim, Ju‐Eun Kim, Hyun Goo Kang, Jiyong Park, Young‐Ho Lee, Kyoung‐Shim Kim, Chul‐Ho Lee, Seung Jae Lee, Mi Hee Lim   +16 more
wiley   +1 more source

Immunocytochemistry [PDF]

, 2020
Melinda S. Camus, Lisa S. Kelly, Anne M. Barger   +2 more
  +4 more sources

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Immunocytochemistry images of expression of extracellular matrix proteins.

, 2019
Representative immunocytochemistry images of expression of extracellular matrix laminin, fibronectin and type I collagen (all in green) in confluent hASCs preserved at 4°C, in the presence and absence (Culture medium) of hypothermic storage solutions for
Rogério Pedro Pirraco (7500257), Mariana Teixeira Cerqueira (7500248), Andreia Filipa Carvalho (7500245), Rui Luís Reis (7500254), Marina Costa (5073269), Sara Freitas-Ribeiro (7500242), Alexandra Pinto Marques (7500251)   +6 more
core   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7. [PDF]

Adv Sci (Weinh)
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Kim Y, Lee G, An S, Park H, Kim H, Kim J, Kang S, Kim S, Kwon D, Park J, Hwang Y, Kim S, Yuan X, Jeong J, Lee H, Kim HK, Kim J.   +16 more
europepmc   +2 more sources

Expression of the neural cell adhesion NCAM in endocrine cells of the ovary [PDF]

, 1991
In the adult mammalian ovary morphogenesis and differentiation processes are under hormonal control and, thus, occur in a highly regulated way during the sexual cycle.
Lahr, G., Gratzl, Manfred, Mayerhofer, Artur   +2 more
core   +1 more source