Results 151 to 160 of about 166,510 (294)

Trafficking and potentiation of Nav1.7 and Nav1.8 channels are mediated by IQGAP1

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend IQGAP1 binds to the voltage‐gated Nav1.7 and Nav1.8 channels and TRPA1 channels in sensory neurons. Inflammatory mediators (IM), including PGE2 and TNFα, released during nerve injury and inflammation activate intracellular signalling messengers such as PKA, p38 MAPK and Cdc42 through their respective receptors.
Xuming Zhang   +2 more
wiley   +1 more source

Photobiomodulation restores blood–brain barrier integrity after hypoxia via endothelial von Willebrand factor modulation in a humanised tricellular transwell model

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Photobiomodulation restores blood–brain barrier (BBB) integrity following hypoxic stress. A multicellular human BBB model comprising brain microvascular endothelial cells, astrocytes and pericytes was established in a transwell system and subjected to acute hypoxia.
Mirriam Domocos   +4 more
wiley   +1 more source

Validation of on-slide immunocytochemistry controls prepared from long-term preserved prefixed cell suspensions. [PDF]

open access: yesCancer Cytopathol
Roque RR   +6 more
europepmc   +1 more source

Pancreatic Islet Cell Crosstalk: Insight Into α‐/β‐Cell Compensatory Mechanisms

open access: yesComprehensive Physiology, Volume 16, Issue 3, June 2026.
α‐cell remodeling compensates for impaired β‐cell function. Intra‐islet glucagon/GLP‐1 signaling is upregulated and becomes essential in prediabetic islets. Flexible receptor engagement reflects functional plasticity in hormonal control of insulin secretion. Created in BioRender. Plecita, L. (2026); https://BioRender.com/pgjjg3m.
Štěpánka Benáková   +5 more
wiley   +1 more source

Pancreatic Adenocarcinoma: Diagnosis by Ultrasound‐Guided Fine‐Needle Aspiration—Cyto‐Histological Correlation and Experience at a Multidisciplinary Tertiary Reference Center

open access: yesDiagnostic Cytopathology, Volume 54, Issue 6, Page 403-416, June 2026.
ABSTRACT Background Pancreatic adenocarcinoma (PDAC) is characterized by its poor prognosis. Cytology is essential for diagnostic confirmation and ancillary studies. The endoscopic ultrasound (EUS) set a precedent, facilitating cytological sampling through fine‐needle aspiration (FNA), with a sensitivity of 93% and a specificity of 95%.
Judith González‐López   +10 more
wiley   +1 more source

Validation of TRPA1 and TRPV1 Antibodies for Expression Detection in Mammalian Cells and Tissues. [PDF]

open access: yesJ Neurochem
de Las Casas M   +6 more
europepmc   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

open access: yesGlia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro   +4 more
wiley   +1 more source

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