Results 131 to 140 of about 130,186 (296)
Brain Pathology, EarlyView.Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová +19 more
wiley +1 more source
Laminin‐5 immunocytochemistry: a new tool for identifying dysplastic cells in oral brush biopsies
, 2007 The brush biopsy technique is not only a seminal technique but also a critically discussed method for detection of oral pre-cancerous stages and manifest carcinomas. The gamma 2 chain of laminin-5 and its proteolytic fragments comprise an invasion factor
Reichert, T. E. +6 more
core +1 more source
Alamandine/MrgD pathway modulates gut–bone marrow axis in ageing
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Ageing is associated with colon epithelial barrier disruption and up‐regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut–
Kishore Chittimalli +6 more
wiley +1 more source
COS Cells Expression Cloning of Tyrosine-phosphorylated Proteins by Immunocytochemistry
, 2000 Tyrosine phosphorylation is an important post-translational modification of proteins, essential in many aspects of the cell economy, particularly in signal transduction pathways. Despite the importance of protein tyrosine phosphorylation, the approaches
Frank W. Sellke, Cesario Bianchi
core +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin +7 more
wiley +1 more source
IMMUNOCYTOCHEMISTRY OF WHOLE-MOUNT PREPARATIONS
, 1994 Virtually any organ and tissue can be studied by means of immunostained “whole-mount preparations”. These are unsectioned portions, or microdissected fragments of an organ largely retaining the original three-dimensional morphology and tissue context ...
Rosa Maria Gaudio +4 more
core +1 more source
Cancer Science, EarlyView.Compared with PT‐CAFs, LN‐CAFs exhibited a myofibroblast‐like phenotype, enhanced tumor stemness‐promoting activity, and fibrosis‐, EMT‐, and hypoxia‐related transcriptomic signatures. LN‐CAF‐related gene signatures were independently associated with poor prognosis in head and neck squamous cell carcinoma.
Hiroyuki Hagiwara +8 more
wiley +1 more source
Cancer Science, EarlyView.Fractionated irradiation generated radioresistant F‐IRR cells with enhanced CSC properties despite slower proliferation. MSI1 was strongly upregulated and functionally promoted stemness, tumorigenicity, and radiation resistance. JNK signaling acted upstream of MSI1, while JNK inhibition suppressed these malignant traits, identifying the JNK–MSI1 axis ...
Na‐Eun Kang +5 more
wiley +1 more source
Cancer Science, EarlyView.LSD1 expression was higher in non‐seminomatous than in seminomatous testicular germ cell tumor components. In embryonal carcinoma models, selective LSD1 inhibition by NCL1 induced epigenetic and apoptotic responses, reduced viability including in cisplatin‐adapted cells, and suppressed early xenograft outgrowth, supporting LSD1 as a potential ...
Nobuhiko Shimizu +16 more
wiley +1 more source