Results 51 to 60 of about 8,528 (179)

Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice

Aging Cell, Volume 25, Issue 8, August 2026.
Targeting of RANKL by genetic and pharmacological approaches ameliorates key features of the progeroid phenotype in Zmpste24−/− mice. RANKL intervention restores bone mass, improves muscle phenotype, and extends survival. These findings support further exploration of RANKL‐targeted therapies for Hutchinson‐Gilford progeria syndrome.
Sandra Freitas‐Rodríguez, Alejandra Valle‐Cao, Francisco Rodríguez, Manuel Fernández‐Sanjurjo, Benjamín Fernández‐García, Vanessa Loredo, María Teresa Fernández‐García, Carmen Fiuza‐Luces, Alejandro Lucia, Carlos López‐Otín, Alejandro López‐Soto, Alicia R. Folgueras   +11 more
wiley   +1 more source

Disruption of Claudin‐2 and Trpv6 Results in Hypocalcemia, Hypercalciuria, and Altered Bone Microarchitecture in Mice

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Transepithelial calcium absorption occurs via a transcellular or paracellular pathway. The intestinal transcellular pathway relies, at least partially, on the apical calcium channel transient receptor potential vanilloid 6 (TRPV6), whereas paracellular calcium (re)absorption occurs through tight junction proteins, including claudin‐2 (CLDN2 ...
Harneet Kaur Bhullar, Amanda Lima Deluque, Debbie D. O'Neil, Wanling Pan, Michael R. Doschak, Henrik Dimke, R. Todd Alexander   +6 more
wiley   +1 more source

Imunodiagnóstico Immunodiagnosis

Memorias do Instituto Oswaldo Cruz, 1992
In the last years, the knowledge about immunodiagnosis in schistosomiasis has increased considerably. This was due to a better immunologic understanding of the host-parasite interaction and the evolution of the technical procedures by the introduction of
Silvia Maria Lucena Montenegro
doaj   +1 more source

Recombinant LPG3 Protein From Leishmania chagasi as an Antigen for the Diagnosis of Canine Visceral Leishmaniasis

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1057-1065, August 2026.
ABSTRACT Visceral leishmaniasis (VL) is a human neglected tropical disease in which dogs participate as reservoirs of the etiological agent Leishmania chagasi. The identification of infected dogs is important to the control of VL, and recombinant proteins are strong antigen candidates for canine visceral leishmaniasis (CVL) serodiagnosis. In this work,
Thaís Viana Fialho Martins, Anna Cláudia Alves de Souza, Bianca Meireles Miranda, Ronny Francisco de Souza, Daniel Silva Sena Bastos, Neverton José Silva Ferreira, Tiago Antônio de Oliveira Mendes, Celeste da Silva Freitas de Souza, George Luiz Lins Machado‐Coelho, Maria Terezinha Bahia, Leandro Licursi de Oliveira, Juliana Lopes Rangel Fietto, Eduardo de Almeida Marques‐da‐Silva   +12 more
wiley   +1 more source

Features Immunodiagnostic Local Forms of Tuberculosis in Children

Эпидемиология и вакцинопрофилактика, 2015
The 100 children with local forms of tuberculosis (LFT) were examinated used by the method of continuous sampling. The results of the LFT immunodiagnostic with the Diaskintest (DST) in the children were evaluated.
E. A. Borodulina, T. E. Ahmerova, Zh. P. Vasneva, E. S. Eremenkо, B. E. Borodulin, E. A. Amosova   +5 more
doaj   +1 more source

Effects of high‐fat diet and treadmill running on bone marrow fat and bone properties in young male mice

Physiological Reports, Volume 14, Issue 15, August 2026.
Abstract We investigated the effects of a high‐fat diet (HFD) and treadmill running on bone marrow fat (BMF) and bone properties in mice. Four‐week‐old male mice (n = 6/group) were assigned to four groups: standard diet (STD) or HFD (60% kcal from fat), under sedentary or exercise conditions.
Yuri Takamine, Noriko Ichinoseki‐Sekine, Takamasa Tsuzuki, Toshinori Yoshihara, Shuichi Machida, Hisashi Naito   +5 more
wiley   +1 more source

Development of a Novel Rapid Immunodiagnostic Kit Based on Flagellar 40 kDa Antigen Epitope for the Detection of Typhoid Fever in Indian Patients

The Scientific World Journal, 2013
To aid the clinical diagnosis of typhoid fever in India, where most hospitals and primary health centres have no facilities for culture, we report on the development of a novel and rapid immunodiagnostic kit for the direct detection of Salmonella Typhi ...
Rahul Mitra, Surya Bhan, Gopal Nath, Narender Kumar, Ziledar Ali   +4 more
doaj   +1 more source

Detection of a Giardia lamblia coproantigen by using a commercially available immunoenzymatic assay, in Belo Horizonte, Brazil Avaliação do ProSpeT Giardia ensaio em microplaca na detecção de coproantígenos de Giardia lamblia, em fezes de pacientes de Belo Horizonte, Brasil

Revista do Instituto de Medicina Tropical de São Paulo, 1999
It is known that fecal examination to detect Giardia lamblia cysts or trophozoites produces a high percentage of false-negative results. A commercially available immunoenzymatic assay (ProSpecT Giardia Microplate Assay, Alexon, Inc., BIOBRÁS) to detect G.
Míriam Oliveira e ROCHA, Rômulo Teixeira de MELLO, Tânia Mara Pinto Dabés GUIMARÃES, Vicente de Paulo Coelho Peixoto de TOLEDO, Maria da Conceição Carneiro Gonçalves MOREIRA, Carlos Alberto da COSTA   +5 more
doaj   +1 more source

End‐to‐End Sensing Systems for Breast Cancer: From Wearables for Early Detection to Lab‐Based Diagnosis Chips

Advanced Materials Technologies, Volume 11, Issue 13, 8 July 2026.
This review explores advances in wearable and lab‐on‐chip technologies for breast cancer detection. Covering tactile, thermal, ultrasound, microwave, electrical impedance tomography, electrochemical, microelectromechanical, and optical systems, it highlights innovations in flexible electronics, nanomaterials, and machine learning.
Neshika Wijewardhane, Lyn I. Jones, Richard M. Martin, Helen Winter, Faezeh Arab Hassani   +4 more
wiley   +1 more source

Design, Expression and Purification of Strongyloides stercoralis IgG4 Immunoreactive Protein (NIE) in Escherichia coli

Iranian Journal of Parasitology, 2020
Background: Strongyloidiasis is a public health concern in northern regions of Iran, caused by Strongyloides stercoralis. Auto-infection cycle can be resulted in high parasitic load, especially in immunocompromised hosts.
Katayoun DASTAN, Mehdi ASSMAR, Nour AMIRMOZAFARI, Fariborz Mansour GHANAEI, Mirsasan MIRPOUR   +4 more
doaj   +1 more source