Results 131 to 140 of about 7,237,819 (287)

A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) functions as a critical stress sentinel that coordinates cell survival, inflammation, and immunogenic cell death (ICD).
Gifford, Valentina, Patin, Emmanuel C., Tenev, T, Udainiya, Savita, Baldock, Holly, Benstead-Hume, Graeme, Upton, Jason, John, SW, Raynaud, Florence, Gabel, F, Hoelder, S, Hoelder, Swen, Wilson, R, Pierrat, Olivier, Craxton, A, Craxton, Andrew, Ramos Garcia, Laura, Roulstone, Victoria, Legrand, Arnaud, Starling, Chris, Tiu, C, Alexander, J, Tenev, Tencho, Upton, J, Gyrd-Hansen, M, Smith, Angel, Roxanis, Ioannis, Bellenie, Benjamin, Guo, Hongyan, Patin, EC, Lyu, Wenxin, Haider, Syed, Roulstone, V, Raynaud, F, Seddon, B, Wilson, Rebecca, Muirhead, Gareth, Cundy, Nicholas J., John, Sidonie Wicky, Gyrd-Hansen, Mads, Choudhary, JS, Goicoechea, Maria, Brennan, A, Moraes de Vasconcelos, Nathalia, Smith, A, Cundy, NJ, Cheung, K-MJ, Tiu, Crescens, Layzell, Scott, Starling, C, MacFarlane, Marion, Roumeliotis, TI, Layzell, S, Goicoechea, M, Brennan, Alfie, Gabel, Florian, Fernando, W, MacFarlane, M, Mannion, Jonathan, Meier, Pascal, Benstead-Hume, G, Guo, H, Choudhary, Jyoti S., Udainiya, S, Cheung, Kwai Ming J., Gifford, V, Guppy, N, Serrano-Aparicio, N, Harrington, K, Allen, Mark, Guppy, Naomi, Bellenie, B, Seddon, Benedict, Pierrat, O, Alexander, John, Mannion, J, Baldock, H, Harrington, Kevin, Roxanis, I, Serrano-Aparicio, Natalia, Roumeliotis, Theodoros I., Ramos Garcia, L, Lyu, W, Fernando, Winnie, Allen, M, Legrand, A, Haider, S, Muirhead, G, Meier, P, Moraes de Vasconcelos, N   +89 more
core   +1 more source

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Nanomedicine to aid immunogenic cell death (ICD)-based anticancer therapy

Immunogenic cell death (ICD) is emerging as a key component of antitumor therapy that harnesses the immune system of the patient to combat cancer. In recent years, several efforts were made to improve the ICD-based therapies.
De Smedt, Stefaan, Demuynck, Robin, Lentacker, Ine, Skirtach, Andre, Engelen, Yanou, Krysko, Dmitri   +5 more
core   +2 more sources

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Modeling of immunogenic cell death

Modélisation de la mort cellulaire immunogène La mort cellulaire immunogène (ICD) est une forme de mort cellulaire qui suscite une réponse immunitaire adaptative unique, la distinguant des autres types de mort cellulaire régulée. Cette caractéristique fait de l'ICD un sujet pertinent dans les domaines de la thérapie contre le cancer et ...
openaire   +2 more sources

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Peptide Aggregation Induced Immunogenic Cell Death

, 2022
Cell death is an inevitable biological outcome, every living thing dies. However, how cells die is an important question and ultimately is decisive in homeostasis and disease progression.
Gunay, Gokhan
core  

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source