Results 241 to 250 of about 329,623 (303)

Impact of CRM197-based conjugate vaccines, schedules, and regions on pneumococcal immunogenicity in young children: systematic review. [PDF]

NPJ Vaccines
Chen X, Tavlian S, Carville KS, Tellioglu N, Spirkoska V, Carvalho N, Price DJ, Campbell PT, McVernon J.   +8 more
europepmc   +1 more source

Cryoablation Activates the cGAS–STING‐CXCL10 Axis in Macrophages to Enhance Anti‐Tumor Immunity in NSCLC

Advanced Science, EarlyView.
Tumor dsDNA released by cryoablation is taken up by macrophages, activating the cGAS‐STING signaling pathway. This leads to an expansion of the CXCL10+ macrophage pool and increased secretion of CXCL10, which in turn recruits CXCR3+ T cells from draining lymph nodes into the tumor microenvironment to exert anti‐tumor effects.
Xinxin Zhi, Zhengcao Xing, Libo Luo, Jiale Wang, Xinyu Liu, Jia Yu, Jizhong Yin, Bin Chen, Yiwei Liu, Hui Sun, Guanghui Gao, Lei Wang, Xiaoxia Chen, Fei Li, Hu Ma, Lin Wang, Shuo Yang, Shengxiang Ren   +17 more
wiley   +1 more source

QX008N, an Anti-TSLP Monoclonal Antibody: Pharmacokinetics, Tolerability, and Immunogenicity in Healthy Chinese Subjects. [PDF]

Clin Transl Sci
Shen ZW, Jiang Q, Wu KQ, Jin TH, Zhao J, Guo T, Fang M, Chen GL.   +7 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Cross-Induction of Anti-Complexing Antibodies in Patients Treated with Botulinum Toxin Formulations Containing Complexing Proteins. [PDF]

Toxins (Basel)
Srinoulprasert Y, Sirisuthivoranunt S, Sripatumtong C, Tansit T, Yamlexnoi P, Meethong O, Wanitphakdeedecha R.   +6 more
europepmc   +1 more source

Safety and immunogenicity of 13-Valent pneumococcal conjugate vaccine in healthy infants in Shanghai during the COVID-19 pandemic: a prospective cohort study. [PDF]

Front Immunol
Xin L, Hong L, Wang S, Qian X, Li Y.
europepmc   +1 more source

Altered genome induced immune response of iPSCs. [PDF]

Front Immunol
Requena Osete J, Álvarez Palomo B, Edel MJ.   +2 more
europepmc   +1 more source

Immunogenicity and safety of 20-valent pneumococcal conjugate vaccine in pneumococcal vaccine-naive adults ≥18 years of age in India: A phase 3 single-arm trial. [PDF]

Hum Vaccin Immunother
Giriappa B, Choraria N, Ponce P, Drozd J, Su X, Lei L, Portka M, Pai S, Anderson A, Bickham K, Watson W, McElwee K.   +11 more
europepmc   +1 more source

The Road to Readiness: Commentary on the Journey of a Zoonotic H5 Influenza Vaccine Strain Update. [PDF]

Vaccines (Basel)
Kennedy AT, Longstaff R, Fitzpatrick J, Hughes C, Malatesta MT, Brandi R, Beighton J, Versage E, Music N, Xu H, Pagni M, Hohenboken M, Taylor B.   +12 more
europepmc   +1 more source