Results 281 to 290 of about 315,728 (345)

A systematic review on malaria and Tuberculosis (TB) vaccine challenges in sub-Saharan African clinical trials. [PDF]

PLoS One
Hamisi MA, Asri NAM, Yassim ASM, Suppian R.   +3 more
europepmc   +1 more source

A Dual‐Response DNA Origami Platform for Imaging and Treatment of Sepsis‐Associated Acute Kidney Injury

Advanced Science, EarlyView.
A dual‐response DNA origami platform is developed for the early diagnosis and therapeutic intervention of sepsis‐associated acute kidney injury. Abstract Current diagnostics for sepsis‐associated acute kidney injury (SA‐AKI) detect kidney damage only at advanced stages, limiting opportunities for timely intervention. A DNA origami‐based nanoplatform is
Yingying Zhao, Yadan Zhao, Yufan Ling, Zhiming Chen, Xiaofeng Wu, Xing Lu, Yao He, Houyu Wang, Fenglin Dong   +8 more
wiley   +1 more source

Production of an immunogenic trivalent poliovirus virus-like particle vaccine candidate in yeast using controlled fermentation. [PDF]

NPJ Vaccines
Sherry L, Grehan K, Bahar MW, Swanson JJ, Fox H, Matthews S, Carlyle S, Qin L, Porta C, Wilkinson S, Robb S, Clark N, Liddell J, Fry EE, Stuart DI, Macadam AJ, Rowlands DJ, Stonehouse NJ.   +17 more
europepmc   +1 more source

Construction of a Biomimetic Tubular Scaffold Inspired by Sea Sponge Structure: Sponge‐Like Framework and Cell Guidance

Advanced Science, EarlyView.
Inspired by the structure of sea sponges, a unique method involving microfluidic coaxial spinning and in situ polymerization is designed. Biomimetic tubular scaffolds ae fabricated. Composed of specific materials such as oxidized bacterial cellulose, bacterial cellulose and polydopamine, these scaffolds have excellent mechanical stability and ...
Si Meng, Nihuan Wu, Jie Fang, Yidan Yu, Xin Tang, Yihan Wang, Xiaokang Deng, Cheng Qi, Tiantian Kong, Tengda Ding, Zhou Liu   +10 more
wiley   +1 more source

Safety and Immunogenicity of the Tetravalent Recombinant COVID-19 Protein Vaccine SCTV01E in Children and Adolescents Aged 3 to 17 Years: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Trial. [PDF]

Vaccines (Basel)
Zhu F, Huang T, Jin P, Zhang L, Jin Z, Zhang W, Yuan D, Wang Z, Deng Y, Li J, Shen X, Fu Y, Li J, Yang X, Li J, Xie L.   +15 more
europepmc   +1 more source

Mitigating Cellular Dysfunction Through Contaminant Reduction in Synthetic circRNA for High‐Efficiency mRNA‐Based Cell Reprogramming

Advanced Science, EarlyView.
This study addresses the challenges of synthetic circular RNAimpurities that trigger immune responses and hinder efficacy. Key immunogenic byproducts are identified and develop a multi‐step purification process that produces ultra‐pure circRNA and enhances yields by over 10‐fold.
Ziwei Zhang, Weiyu Li, Xiangyu Ren, Dengwang Luo, Xiushuang Yuan, Li Yu, Daming Wang, Yuhong Cao   +7 more
wiley   +1 more source

Associations Between Histo-blood Group Antigen Status in Mother-Infant Dyads and Infant Oral Rotavirus Vaccine Immunogenicity in Rural Zimbabwe. [PDF]

J Infect Dis
Pun J, Evans C, Chasekwa B, Church JA, Gough E, Mutasa K, Rukobo S, Govha M, Mushayanembwa P, Majo FD, Tavengwa NV, Humphrey JH, Kirkpatrick BD, Kosek M, Ntozini R, Prendergast AJ.   +15 more
europepmc   +1 more source

An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors

Advanced Science, EarlyView.
A peptide library screening platform has been developed to discover covalent transcription factor inhibitors. It identifies an antagonist cysteine residue, which forms an inhibitory disulphide with cJun C269. Conversion of this cysteine to an electrophile generates an irreversible and selective cJun inhibitor, validating this approach for covalent ...
Andrew Brennan, Scott Lovell, Keith W Vance, Jody M Mason   +3 more
wiley   +1 more source

Natural Enzyme‐Loaded Polymeric Stealth Coating‐Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism‐Immuno‐Enzyme Dynamic Therapy

Advanced Science, EarlyView.
Engineered Lactobacillus acidophilus (LH@LA) is developed via in situ polymerization to co‐load lactate oxidase (LOx) and horseradish peroxidase (HRP). This system preserves LA activity, evades macrophage phagocytosis, and synergizes LA metabolism with enzyme cascades to enhance immunity, reduce tumor ATP, suppress PD‐L1 expression and AKT‐mTOR ...
Liuzhou Mao, Bahriman Xarpidin, Rui Shi, Yuting Lin, Haohua Hu, Caisheng Wu, Zheng Luo, Yun‐Long Wu   +7 more
wiley   +1 more source

Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy

Advanced Science, EarlyView.
In this study, a targeting PFKFB4 biomimetic codelivery system is developed to improve paclitaxel efficacy by inducing ferroptosis in SCLC. This system enhances immune cell infiltration and cytokine secretion, activating anti‐tumor immunity. Combined with anti‐PD‐L1, it boosts immune responses, offering a novel therapeutic strategy for overcoming ...
Xiang Liu, Jingjun He, Haoxuan Ying, Cuiying Chen, Chongyang Zheng, Peng Luo, Weiliang Zhu, Ting Wei, Bufu Tang, Jian Zhang   +9 more
wiley   +1 more source