Results 301 to 310 of about 456,487 (388)

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition

Advanced Science, EarlyView.
The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Lundqvist Andreas, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang   +20 more
wiley   +1 more source

Dual‐Crosslinked Betaine‐Based Amphiphilic Hydrogel as a Promising Vitreous Substitute: Anti‐Adhesion, Anti‐Fouling, and Anti‐Cell Proliferation

Advanced Science, EarlyView.
A novel multiple cross‐linked betaine‐type amphiphilic polymer hydrogels are developed via in situ free radical copolymerization. The resultant formation, named P(SBMA‐co‐AANa) hydrogel, functions as a vitreous substitute and demonstrates superior performance in optical properties, support capacity, and biocompatibility on a vitrectomized rabbit model.
Yuting Cai, Yun Tan, Jian Cao, Xiaoyuan Zhou, Xingyuan Li, Jianghua Li, Chuntai Liu, Yi Zhang, Yun Li   +8 more
wiley   +1 more source

piR‐RCC Suppresses Renal Cell Carcinoma Progression by Facilitating YBX‐1 Cytoplasm Localization

Advanced Science, EarlyView.
PIWI‐interacting RNAs (piRNAs), a novel category of small non‐coding RNAs, have been implicated in the development of various diseases. This study explores the tumor‐suppressive mechanism of a downregulated piRNA (designated piR‐RCC) in renal cell carcinoma (RCC), and provides a delivery strategy targeting RCC tumor by constructing a cell membrane ...
Ruyue Wang, Fan Li, Yudong Lin, Zeyi Lu, Wenqin Luo, Zhehao Xu, Ziwei Zhu, Yi Lu, Xudong Mao, Yang Li, Zhinian Shen, Haohua Lu, Yining Chen, Liqun Xia, Mingchao Wang, Lifeng Ding, Gonghui Li   +16 more
wiley   +1 more source

Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

Cell, 2016
T. Vatanen, A. Kostic, Eva d’Hennezel, Heli Siljander, E. Franzosa, M. Yassour, R. Kolde, H. Vlamakis, Timothy D. Arthur, A. Hämäläinen, A. Peet, V. Tillmann, R. Uibo, Sergei Mokurov, N. Dorshakova, J. Ilonen, S. Virtanen, S. Szabo, Jeffrey A. Porter, H. Lähdesmäki, C. Huttenhower, D. Gevers, T. W. Cullen, M. Knip, R. Xavier   +24 more
semanticscholar   +1 more source

Correction to: Efficacy, Safety, and Immunogenicity of SDZ-ADL, an Adalimumab Biosimilar, in Biologic-Naïve and Switched Patients with Immune-Mediated Inflammatory Diseases: A Literature Review. [PDF]

Adv Ther
Wiland P, Both C, Gaylis NB, Cohen RD, Halfvarson J, Lemke L, von Richter O, Blauvelt A.   +7 more
europepmc   +1 more source

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei   +11 more
wiley   +1 more source

IMMUNOGENICITY IN MONKEYS OF A COMBINED TOXOID FROM THE MAIN TOXIC PRINCIPLES SEPARATED FROM HABU SNAKE VENOM

, 1970
Hisashi Kondo, Seiji Sadahiro, Satoru Kondo, KIYOSUMI YAMAUCHI, Shigeo Honjo, Fumiaki Cho, Akira Ohsaka, Ryosuke Murata   +7 more
openalex   +2 more sources

Sexual dimorphism-driven differences are overcome in a preclinical vaccine model against <i>Trypanosoma cruzi</i>. [PDF]

Front Immunol
Bulfoni Balbi C, Pacini MF, Dinatale B, Farré C, Cacik P, Prochetto E, González FB, Marcipar I, Cabrera G, Pérez AR.   +9 more
europepmc   +1 more source

RNA Circularization Diminishes Immunogenicity and Can Extend Translation Duration In Vivo.

Molecules and Cells, 2019
R. A. Wesselhoeft, Piotr S. Kowalski, Frances C Parker-Hale, Yuxuan, Huang, Namita Bisaria, Daniel G. Anderson   +6 more
semanticscholar   +1 more source

Disruption of ARID1B Recruitment to the Nuclear Pore Complex as a New Anticancer Therapeutic Strategy

Advanced Science, EarlyView.
This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz, Anupam Banerjee, Xin Cui, Lidan Zeng, Amad Uddin, Christopher Li, Yueming Zhu, Mengyuan Zhang, Xiaodong Lu, Nagendra S. Yarla, Lu Wang, Jindan Yu, Jonathan C. Zhao, Ivet Bahar, Yong Wan   +14 more
wiley   +1 more source