Results 311 to 320 of about 456,487 (388)

Nipah virus vaccines evaluated in pigs as a 'One Health' approach to protect public health. [PDF]

NPJ Vaccines
McLean RK, Pedrera M, Thakur N, Elrefaey AME, Hodgson S, Lowther S, Reid T, Todd S, Rowe B, Bergfeld J, Trinidad L, Riddell S, Edwards S, Payne J, Barr J, Rye N, Bruce M, Poole T, Brown S, Dalziel T, Au G, Fisher M, Layton R, Lambe T, Chappell K, Isaacs A, Watterson D, Mourino M, Raue R, Shanta IS, Siddika A, Begum MN, Rahman S, Bhuyan AAM, Alam M, Rahman MZ, Rahman M, Tchilian E, Gilbert SC, Young P, Bailey D, Marsh GA, Graham SP.   +42 more
europepmc   +1 more source

Optogenetic‐Controlled iPSC‐Based Vaccines for Prophylactic and Therapeutic Tumor Suppression in Mice

Advanced Science, EarlyView.
This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao, Lingxue Niu, Zhihao Wang, Di Dai, Shasha Tang, Xiaoding Ma, Zhenqiang Deng, Guiling Yu, Yang Zhou, Tao Yan, Xingwan Liu, Deqiang Kong, Linfeng Hu, Xiang Li, Junwei Zhao, Fengfeng Cai, Meiyan Wang, Haifeng Ye   +17 more
wiley   +1 more source

Tetanus toxin. The effect of chemical modifications on toxicity, immunogenicity, and conformation.

, 1975
John P. Robinson, John B. Picklesimer, David Puett   +2 more
openalex   +1 more source

NOTCH1 inhibition enhances immunogenicity and sensitizes triple-negative breast cancer to immune checkpoint inhibitors. [PDF]

Breast Cancer Res
Gao Y, Zuo L, Zheng Y, Sun K, Gao Y, Xu X, Li Z, Zuo D.   +7 more
europepmc   +1 more source

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, Volume 12, Issue 28, July 24, 2025.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source

IMMUNOGENICITY OF HLA ANTIGENS PURIFIED FROM SERUM1

, 1977
Soldano Ferrone, Kamal K. Mittal, Michele Pellegrino, James P. Allison, Ralph A. Reisfeld   +4 more
openalex   +1 more source

Immunogenicity and safety of hepatitis A vaccine at different vaccination intervals among adults aged 18 years and above: Interim results. [PDF]

Hum Vaccin Immunother
Chang L, Li Z, Liu Y, Fei S, Zhao L, Li J, Huang W, Yang Y, Tuo L, Feng B, Wu X, Zhao Y, Li J, Fang X.   +13 more
europepmc   +1 more source

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Preclinical evaluation of a live avian metapneumovirus subtype B vaccine strain with cross-protective efficacy in chickens. [PDF]

Poult Sci
Kim SJ, Kim HJ, Noh YH, Won HK, Hong SM, Yoon IJ, Choi KS.   +6 more
europepmc   +1 more source

An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum

Advanced Science, EarlyView.
This work presents a strategy for engineering thermophilic Ago proteins to obtain wide catalytic temperature range and broad substrate spectrum. This strategy is applied to engineer PfAgo and TtdAgo, and the biochemical properties of the engineered PfAgo are systematically characterized. The study further elucidates the structural differences involved.
Longyu Wang, Xiaochen Xie, Fuyong Huang, Qiang Wei, Tianxin Cai, Na Yu, Shi Chen, Fei Wang, Wanping Chen, Chin‐yu Chen, Chunhua Li, Lixin Ma   +11 more
wiley   +1 more source