Results 71 to 80 of about 66,232 (237)
Advanced Healthcare Materials, EarlyView.Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari +10 more
wiley +1 more source
, 2011 [[abstract]]Efficacy and safety are two of the key challenges in vaccine and immunotherapy technology. To these ends, one needs to strengthen manipulating and to deepen understanding the immune system.
Huang, MH;Leng, CH;Liu, SJ;Chen, HW;Sia, C;Chong, P
core
Advanced Materials, EarlyView.Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song +14 more
wiley +1 more source
Immunogenicity remodeling in hepatocellular carcinoma: mechanisms and translational strategies
Therapeutic Advances in Medical OncologyHepatocellular carcinoma (HCC) continues to pose a significant global health challenge. In recent years, immunotherapy has emerged as a critical component of HCC treatment, demonstrating encouraging outcomes in a subset of patients.
Yali Li +8 more
doaj +1 more source
Immunogenicity of red blood cell blood group antigens in the population of Xi'an
Zhongguo shuxue zazhi[Objective] To evaluate the immunogenicity of red blood cell blood group antigens in the population of Xi'an. [Methods] Data on blood group antigens of voluntary blood donors from the Shaanxi Province Blood Center and unexpected antibody detection ...
ZHANG Liangzi +6 more
doaj +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
Polysorbates, peroxides, protein aggregation, and immunogenicity – a growing concern [PDF]
Aggregation can have a number of deleterious effects on biotherapeutics including the loss of efficacy, the induction of unwanted immunogenicity, altered pharmacokinetics, and reduced shelf life. Aggregation is ameliorated by the inclusion of surfactants
Edward T. Maggio
core +1 more source
Advanced Materials, EarlyView.A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian +7 more
wiley +1 more source
Poor immune response to inactivated COVID-19 vaccine in patients with hypertension
Frontiers in MedicinePurposeThe safety and efficacy of vaccination in people with hypertension (HTN) is important. There are currently a few data on the immunogenicity and safety of inactivated SARS-CoV-2 vaccinations in hypertension patients.MethodsAfter receiving a two ...
Lei Yang +4 more
doaj +1 more source
Predicting Immunogenicity Risk in Biopharmaceuticals
, 2021 The assessment of immunogenicity of biopharmaceuticals is a crucial step in the process of their development. Immunogenicity is related to the activation of adaptive immunity.
Irini Doytchinova +2 more
core +1 more source