Results 71 to 80 of about 267,464 (292)

Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A [PDF]

, 2013
© 2013 Matsumiya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Helen McShane (80704), Pathan, Ansar A, Stylianou, E, Lang, Z, Stephanie A. Harris (429956), Elena Stylianou (292312), Matsumiya, Magali, Griffiths Kristin, Lang Zoe, McShane Helen, Meyer, Joel, Magali Matsumiya, Griffiths, Kristin, Zoe Lang (429954), Lang, Zoe, Ansar A Pathan, Meyer, J, Angela M. Minassian (345365), Magali Matsumiya (429952), Fletcher Helen, Harris, Stephanie A, Rowland Rosalind, Meyer Joel, Kristin Griffiths (429953), Joel Meyer, Harris, SA, McShane, H, Fletcher, Helen, McShane, Helen, Minassian, Angela M, Zoe Lang, Rowland, Rosalind, Matsumiya Magali, Minassian Angela M., Angela M Minassian, Kristin Griffiths, Pathan Ansar A., Joel Meyer (429955), Helen Fletcher, Harris Stephanie A., Rowland, R, Rosalind Rowland, Matsumiya, M, Pathan, AA, Fletcher, H, Minassian, AM, Helen Fletcher (249210), Rosalind Rowland (429957), Helen McShane, Griffiths, K, Elena Stylianou, Stephanie A Harris, Ansar A. Pathan (80697), Stylianou, Elena, Stylianou Elena   +54 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Associations between genetic variations of HLA and IGHV, vaccination schedule, and COVID-19 vaccine immunogenicity

npj Vaccines
Interindividual genetic variations significantly influenced SARS-CoV-2-specific immunogenicity after vaccination, particularly for human leukocyte antigen (HLA) alleles.
Limei Ke, Guoqing Feng, Keyi Lyu, Bo Yin, Wen Fang, Qian Di   +5 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Immunogenicity of therapeutic peptide products: bridging the gaps regarding the role of product-related risk factors

Frontiers in Immunology
The global market for therapeutic peptides is projected to continue to grow at a fast pace in the coming years in response to high demand for these products. The increasing complexity of chemical and recombinant peptide manufacturing processes may impact
Montserrat Puig, Sophie Shubow
doaj   +1 more source

Vaccine delivery systems based on amphiphilic bioresorbable polymers and their role in vaccine immunogenicity

, 2011
[[abstract]]Efficacy and safety are two of the key challenges in vaccine and immunotherapy technology. To these ends, one needs to strengthen manipulating and to deepen understanding the immune system.
Huang, MH;Leng, CH;Liu, SJ;Chen, HW;Sia, C;Chong, P
core  

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Advanced Healthcare Materials, EarlyView.
Recent advances in microfluidic technologies for microgel fabrication are critically reviewed, highlighting the capabilities and limitations of major microfluidic platforms and discussing how platform design, material selection, and crosslinking strategies influence microgel architecture and functionality. Current challenges and future opportunities in
Afshin Abrishamkar, Laura Neely, Cynthia Pham, Nada Ibrahim, Alexis Larios‐Cervantes, Ben A. Kertesz, Todd Hoare   +6 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Immunogenicity and safety of the CoronaVac vaccine in patients with cancer receiving active systemic therapy

, 2021
Aim: To evaluate the immunogenicity and safety of the CoronaVac vaccine in patients with cancer receiving active systemic therapy. Methods: This multicenter, prospective, observational study was conducted with 47 patients receiving active systemic ...
Aykan, Musa Barış, Uncu, Doğan, İmamoğlu, Göksen İnanç, Eren, Tülay, Basal, Fatma Bugdayci, Sütçüoğlu, Osman, Zeynelgil, Esra, Karadurmuş, Nuri, Karadağ, İbrahim, Öksüzoğlu, Ömür Berna, Altınbaş, Mustafa, Dinç, Bedia, YAZICI, OZAN, Karaçin, Cengiz, Yıldız, Yeşim, Çelik, İsmail, Doğan, Mutlu, Bilgetekin, İrem, YILDIZ, YEŞİM, Altinbas, Mustafa, Yazıcı, Ozan, Özet, Ahmet, Ertürk, İsmail, Aykan, Musa Baris, Esen, Selin Aktürk, Uçar, Gökhan, Ergun, Yakup, Özdemir, Nuriye, Başal, Fatma Buğdaycı, Civelek, Burak, İsmail Erturk, Esra Zeynelgil, Goksen Inanc Imamoglu, Ahmet Ozet, Fatma Bugdayci Basal, Bedia Dinc, Omur Berna Oksuzoglu, Irem Bilgetekin, Tulay Eren, İsmail Çelik, Mutlu Dogan, Dogan Uncu, Selin Akturk Esen, Nuri Karadurmus, Ibrahim Karadag, Gokhan Ucar, Ozan Yazici, Osman Sutcuoglu, Mustafa Altinbas, Yakup Ergun, Yesim Yildiz, Musa Baris Aykan, Burak Civelek, Cengiz Karacin, Nuriye Ozdemir   +54 more
core   +1 more source