Results 71 to 80 of about 329,623 (303)

Associations between genetic variations of HLA and IGHV, vaccination schedule, and COVID-19 vaccine immunogenicity

npj Vaccines
Interindividual genetic variations significantly influenced SARS-CoV-2-specific immunogenicity after vaccination, particularly for human leukocyte antigen (HLA) alleles.
Limei Ke, Guoqing Feng, Keyi Lyu, Bo Yin, Wen Fang, Qian Di   +5 more
doaj   +1 more source

From Clinic to Computation: Multiscale Bioengineering Strategies for Durable Biological Aortic Valve Replacements

Advanced Functional Materials, EarlyView.
Bioprosthetic aortic valves have revolutionized the treatment of aortic stenosis, but their durability is limited by structural valve deterioration (SVD). This review focuses on the pericardial tissue at the heart of these valves, examining how its mechanical properties and calcification drive fatigue and failure.
Gabriele Greco, Pierfrancesco Gaziano, Serena Anglese, Simone Morganti, Carlo de Vincentiis, Ferdinando Auricchio, Michele Marino, Michele Conti   +7 more
wiley   +1 more source

Chimerism and xenotransplantation: New concepts [PDF]

, 1999
In both transplant and infectious circumstances, the immune response is governed by migration and localization of the antigen. If the antigenic epitopes of transgenic xenografts are sufficiently altered to avoid evoking the destructive force of innate ...
Demetris, AJ, Fung, JJ, Murase, N, Rao, AS, Starzl, TE, Thomson, A   +5 more
core   +1 more source

Immunogenicity of Rhinoviruses

Experimental Biology and Medicine, 1970
SummaryUniformly successful production of rabbit rhinovirus antisera depended on production of immunogens with virus concentrations of at least 107 pfu/ml. Response in pairs of rabbits immunized with the same antigen appeared to be remarkably uniform, and maximum antibody titers were attained at 38 to 45 days after beginning a relatively simple ...
M K, Cooney, G E, Kenny
openaire   +2 more sources

In Situ 3D Bioprinting: Impact of Cross‐Linking on the Adhesive Properties of Hydrogels

Advanced Functional Materials, EarlyView.
In situ 3D bioprinting enables the direct deposition of cell‐laden, adhesive biomaterials for on‐site tissue regeneration. This review provides a comprehensive overview of how cross‐linking influences the bioadhesive properties of hydrogels used in 3D bioprinting, highlighting cross‐linking triggers, bioadhesion mechanisms, polymer interpenetration ...
Odile Romero Fernandez, Mulazim Hussain Asim, Shumaila Arshad, Gergely Kali, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

Immunogenicity of therapeutic peptide products: bridging the gaps regarding the role of product-related risk factors

Frontiers in Immunology
The global market for therapeutic peptides is projected to continue to grow at a fast pace in the coming years in response to high demand for these products. The increasing complexity of chemical and recombinant peptide manufacturing processes may impact
Montserrat Puig, Sophie Shubow
doaj   +1 more source

Parenteral vaccination of mammalian livestock with Newcastle disease virus-based vector vaccines offers optimal efficacy and safety [PDF]

, 2011
Newcastle disease virus (NDV) is an avian virus that is being evaluated as a vaccine vector for the delivery of foreign genes in mammals. The use of NDV as a vaccine vector in these species offers two major advantages.
Antonis, A.F.G., Harmsen, M.M., Kortekaas, J.A., Moormann, R.J.M.   +3 more
core   +2 more sources

An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light

Advanced Functional Materials, EarlyView.
NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee, Stefanie S. M. Meier, Sara Trujillo, Andreas Möglich, Shrikrishnan Sankaran   +4 more
wiley   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Immunogenicity of NS4b dengue 3 virus mimotope presented to the immune system as multiple antigen peptide system [PDF]

, 2013
The availability of random peptide libraries displayed on bacteriophage (RPL) has provided a powerful tool for selecting sequences that mimic binding properties of natural antigen epitopes (mimotopes). These mimotopes can be used for vaccine design, drug
Acosta, Armando, Aguilar, Alicia, Alvarez, Mayling, Amin, Nevis, Caballero, Yamira, Camacho, Frank, Díaz, Daiyana, García, Angélica, Guzmán, María Guadalupe, Pupo, Maritza, Reyes, Osvalda, Stott, David I.   +11 more
core   +2 more sources