Results 81 to 90 of about 66,232 (237)
Bioengineered Interfaces for Peripheral Nerve Sensory Restoration
Advanced Materials, EarlyView.Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick +4 more
wiley +1 more source
A modular protein language modelling approach to immunogenicity prediction.
PLoS Computational BiologyNeoantigen immunogenicity prediction is a highly challenging problem in the development of personalised medicines. Low reactivity rates in called neoantigens result in a difficult prediction scenario with limited training datasets.
Hugh O'Brien +15 more
doaj +1 more source
Advanced Materials, EarlyView.This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris +11 more
wiley +1 more source
Comparison of “framework Shuffling” and “CDR Grafting” in humanization of a PD-1 murine antibody
Frontiers in ImmunologyIntroductionHumanization is typically adopted to reduce the immunogenicity of murine antibodies generated by hybridoma technology when used in humans.MethodsTwo different strategies of antibody humanization are popularly employed, including ...
Yongmei Wang +18 more
doaj +1 more source
Molecular shape and immunogenicity of meningococcal polysaccharide group A conjugate vaccine
, 2015 Neisseria meningitidis is a leading cause of severe bacterial infections in infants and young children. As a major virulence factor, meningococcal capsular polysaccharide (PS) is poorly immunogenic and generally does not induce immunological memory ...
Wu, Zhonghua +4 more
core +1 more source
, 2020 Given the expanding number of complex therapeutic protein drugs and advanced therapy medicinal products that are being developed, improving our ability to assess the potential immunogenicity of biologics is critical to ensuring treatment efficacy and ...
Richards S +13 more
core +1 more source
Advanced Materials Interfaces, EarlyView.Biocompatible Mn‐doped TiO2 nanozymes integrate TiO2 stability with Mn redox activity, enabling dopamine‐mediated cell‐surface polymerization and single‐cell nanoencapsulation while maintaining high colloidal stability, low ROS generation, and excellent cellular compatibility.
Filip Kozłowski +6 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyIntroductionMalaria, caused by Plasmodium vivax, remains a major global health problem, particularly in tropical and subtropical regions. This study aimed to investigate the potential of PvVir14-derived peptides to improve diagnostic accuracy for P ...
Ramayana Morais de Medeiros Brito +19 more
doaj +1 more source
Advanced Materials Technologies, EarlyView.Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le +4 more
wiley +1 more source