Results 91 to 100 of about 616,488 (308)

Gene conversion in human rearranged immunoglobulin genes [PDF]

, 2006
Over the past 20 years, many DNA sequences have been published suggesting that all or part of the V_H segment of a rearranged immunoglobulin gene may be replaced in vivo. Two different mechanisms appear to be operating. One of these
A Martin, B Elliott, C-L Parng, CB Kobrin, CR Winstead, D Lenze, D Sehgal, David I. Stott, E Selsing, EJ Steenbergen, EJ Steenbergen, EJ Steenbergen, H Arakawa, H Zan, HF Tsai, IB Rogozin, IB Rogozin, JM Darlow, John M. Darlow, K Itoh, LJ Wysocki, M Reth, MR Lucier, MS Neuberger, N D’Avirro, N D’Avirro, PC Wilson, PD Weinstein, R Dildrop, R Kleinfield, R Rosenquist, R Wasserman, RC Beale, RS Becker, SJ Foster, U Krawinkel, V David, WT McCormack, Y Choi, Z Zhang, É Gontier   +40 more
core   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Limited humoral immunoglobulin E memory influences serum immunoglobulin E levels in blood [PDF]

Clinical & Experimental Allergy, 2009
SummaryThe switch of B cells expressing membrane‐bound Igs, which serve as antigen receptors, to antibody‐secreting plasmablasts and finally to non‐dividing, long‐lived plasma cells (PCs) lacking an antigen receptor, marks the terminal differentiation of a B cell.
Achatz-Straussberger, G., Zaborsky, N., Königsberger, S., Feichtner, S., Lenz, S., Peckl-Schmid, D., Lamers, M., Achatz, G.   +7 more
openaire   +3 more sources

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Kaluzab, Brigitte, Schwirzke, Marina, Weidle, Ulrich H., Weiss, Elisabeth H., Weissenhorn, Winfried   +4 more
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Targeted therapy of bronchial asthma in children and adolescents: А narrative review

Фармация и фармакология (Пятигорск)
The aim. To evaluate the results of clinical studies on the efficacy and safety of bronchial asthma (BA) therapy with genetically engineered biologicals (GEBP) in children and adolescents.Materials and methods.
M. S. Matevosova, L. I. Agapitov, I. A. Averina, I. V. Sokolova, S. V. Zotova, R. A. Chernigovskiy   +5 more
doaj   +1 more source

Immunofluorescent Examination of Biopsies from Long-Term Renal Allografts [PDF]

, 1970
Immunofluorescent examination of open renal biopsies revealed clear-cut glomerular localization of immunoglobulins not related clearly to the quality of donor-recipient histocompatibility in 19 of 34 renal allografts.
Busch, Edgington, F. J. Dixon, J. J. McPhaul, L. Brettschneider, Peterson, Porter, Porter, Starzl, T. E. Starzl   +9 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Correlating Salivary Levels of Immunoglobin E and Human Eosinophil Cationic Protein in the Aseer Cohort with Recurrent Apthous Stomatitis

International Journal of General Medicine, 2023
Khalil Assiri,1 Jagadish Hosmani,1 Sandeepa Nuchilakath Chalikkandy,1 Abdullah M Alkahtani,2 Raghad Mohammed Alhanif,3 Sarah Ahmed Alsarh,3 Shankargouda Patil,4 Rodolfo Reda,5 Luca Testarelli5 1Department of Diagnostic Dental Sciences, College of ...
Assiri K, Hosmani J, Chalikkandy SN, Alkahtani AM, Alhanif RM, Alsarh SA, Patil S, Reda R, Testarelli L   +8 more
doaj  

Serum IgE as a Biomarker of Severity and Short-term Treatment Response in Steroid-naïve Children with Asthma: A Hospital-based Prospective Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Paediatric asthma is a growing public health challenge in Low- and Middle-Income Countries (LMICs), with increasing prevalence and substantial morbidity.
Kishore Alagesan, Prasanna Raju, Vaishnavi Sivaji, Preethi Suresh, Padmanaban Srinivasan, Subash Sundar   +5 more
doaj   +1 more source