Results 1 to 10 of about 49,097 (225)
PLoS ONE, 2023 The importance and fast growth of therapeutic monoclonal antibodies, both innovator and biosimilar products, have triggered the need for the development of characterization methods at high resolution such as nuclear magnetic resonance (NMR) spectroscopy.
Donald Gagné +12 more
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Structure of an immunoglobulin Fab fragment specific for triple-stranded DNA.
Journal of Biological Chemistry, 1994 Triple-stranded DNA of the form poly(Pyr).poly-(Pur).poly(Pyr) (where Pyr represents a pyrimidine, and Pur represents a purine) has become the subject of intense research because of its potential use in the control of gene expression and in the development of sequence-specific reagents for cleaving DNA.
Mol, Clifford D. +4 more
openaire +4 more sources
BioTechniques, 2012 A eukaryotic cell-free system based on Spodoptera frugiperda cells was developed for the convenient synthesis of Fab antibody fragments and other disulfide bridge containing proteins.
Helmut Merk +4 more
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Structure of an immunoglobulin Fab fragment specific for poly(dG).poly(dC).
Journal of Biological Chemistry, 1994 Jel 72 is a murine monoclonal antibody that is highly specific for the right-handed DNA duplex formed by poly(dG).poly(dC). The three-dimensional structure of the antigen-binding fragment (Fab) of Jel 72 has been determined by x-ray crystallographic methods and refined to 2.7-A resolution.
C D, Mol +3 more
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De novo discovery of peptide-based affinity ligands for the fab fragment of human immunoglobulin G
Journal of Chromatography A, 2022 Antibody fragments and their engineered variants show true potential as next-generation therapeutics as they combine excellent targeting with superior biodistribution and blood clearance. Unlike full antibodies, however, antibody fragments do not yet have a standard platform purification process for large-scale production.
Xingqing Xiao +5 more
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Detection of immunoglobulin A1 protease-induced Fab alpha fragments on dental plaque bacteria [PDF]
Infection and Immunity, 1991 The mechanisms by which immunoglobulin A1 (IgA1) protease activity may enable bacteria to evade the effect of specific secretory IgA (S-IgA) antibodies are not clear. A possibility which has received indirect experimental support is that bacteria, as a consequence of the protease activity, become coated with incompetent Fab alpha fragments instead of ...
T, Ahl, J, Reinholdt
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Effect of IgG fragments in IVIG(pH4)on phagocytosis of sensitized erythrocytes by macrophage
Zhongguo shuxue zazhi, 2022 Objective To research the effect of the Fc, Fab and F(ab′)2 fragments of immunoglobulin G, the main components of Human Immunoglobulin(pH4) for Intravenous Injection(IVIG), on the phagocytic function of macrophages derived from THP-1 cells. Methods First
Liyuan ZHU +6 more
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The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement
Nature Communications, 2022 Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases.
Maximilian Brinkhaus +13 more
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Scientific Reports, 2023 With increased accessibility and tissue penetration, smaller antibody formats such as antibody fragments (Fab) and single chain variable fragments (scFv) show potential as effective and low-cost choices to full-length antibodies.
Aatir A. Tungekar, Lloyd W. Ruddock
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Direct IgG epitope mapping on bacterial AB toxins by cryo-EM
STAR Protocols, 2021 Summary: This cryo-EM protocol was used to determine the B cell epitope map on the CdtB subunit of typhoid toxin, an A2B5 toxin secreted by Salmonella Typhi during infection.
Tri Nguyen, Jeongmin Song
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