Results 11 to 20 of about 49,117 (237)

The use of Fab fragments of anti-human immunoglobulin as analytic tools for establishing the involvement of immunoglobulin in the spontaneous cytotoxicity to cultured tumor cells by lymphocytes from patients with bladder carcinoma and from healthy donors.

Journal of Immunology, 1977
The effect of Fab fragments of rabbit anti-human immunoglobulin on the lysis of allogeneic cultured bladder tumor cells by lymphocytes from patients with urinary bladder carcinoma or by lymphocytes from healthy donors was assayed by 51Cr-release ...
M. Troye, P. Perlmann, G. Pape, H. Spiegelberg, I. Näslund, A. Gidlöf   +5 more
semanticscholar   +3 more sources

Solid-phase conjugation of ferritin to Fab-fragments of immunoglobulin G for use in antigen localization on thin sections.

Proceedings of the National Academy of Sciences of the United States of America, 1972
J. Kraehenbuhl, J. Jamieson
semanticscholar   +3 more sources

First clinical experience with fractionated intracavitary radioimmunotherapy using [177Lu]Lu-6A10-Fab fragments in patients with glioblastoma: a pilot study

EJNMMI Research, 2023
Background Following resection and standard adjuvant radio- and chemotherapy, approved maintenance therapies for glioblastoma are lacking. Intracavitary radioimmunotherapy (iRIT) with 177Lu-labeled 6A10-Fab fragments targeting tumor-associated carbonic ...
Wolfgang Roll, Michael Müther, Guido Böning, Astrid Delker, Nils Warneke, Franz-Josef Gildehaus, Michael Schäfers, Walter Stummer, Reinhard Zeidler, Hans-Jürgen Reulen, Lars Stegger   +10 more
doaj   +1 more source

Monovalent Fab' immunoglobulin fragments from endemic pemphigus foliaceus autoantibodies reproduce the human disease in neonatal Balb/c mice.

Journal of Clinical Investigation, 1990
B. Rock, Ramzy S. Labib, L. Diaz
semanticscholar   +3 more sources

A Fab-Selective Immunoglobulin-Binding Domain from Streptococcal Protein G with Improved Half-Life Extension Properties. [PDF]

PLoS ONE, 2015
Half-life extension strategies have gained increasing interest to improve the pharmacokinetic and pharmacodynamic properties of protein therapeutics. Recently, we established an immunoglobulin-binding domain (IgBD) from streptococcal protein G (SpGC3) as
Felix Unverdorben, Meike Hutt, Oliver Seifert, Roland E Kontermann   +3 more
doaj   +1 more source

Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation [PDF]

, 2020
An inverse electron demand Diels–Alder reaction between tetrazine and trans-cyclooctene (TCO) holds great promise for protein modification and manipulation.
Chudasama, V., Kuan, S., Nogueira, J., Raabe, M., Weil, T., Xu, L., Zegota, M.   +6 more
core   +1 more source

Binding between the neural cell adhesion molecules axonin-1 and Nr- CAM/Bravo is involved in neuron-glia interaction [PDF]

, 1995
Neural cell adhesion molecules of the immunoglobulin superfamily mediate cellular interactions via homophilic binding to identical molecules and heterophilic binding to other family members or structurally unrelated cell-surface glycoproteins.
Buchstaller, Andrea, Dreyer, William J., Giger, Roman J., Pollerberg, G. Elisabeth, Sonderegger, Peter, Suter, Daniel M.   +5 more
core   +4 more sources

The Solution Structures of Two Human IgG1 Antibodies Show Conformational Stability and Accommodate Their C1q and FcγR Ligands. [PDF]

, 2015
The human IgG1 antibody subclass shows distinct properties compared with the IgG2, IgG3, and IgG4 subclasses and is the most exploited subclass in therapeutic antibodies. It is the most abundant subclass, has a half-life as long as that of IgG2 and IgG4,
Abe, Andrusier, Ashish, Ashton, Boehm, Brekke, Bruhns, Brüggemann, Calmettes, Collins, Dall'Acqua, Dangl, Davies, Deisenhofer, Diebolder, Dorai, Feinstein, Furtado, Gaboriaud, Gar Kay Hui, Garcia de la Torre, García De La Torre, Glatter, Gregory, Guddat, Guex, Hamilton, Harris, Harris, Heenan, Hezareh, Hughes-Jones, Idusogie, Isenman, Iwura, Jayesh Gor, Jefferis, Kilár, Klein, Laue, Lilyestrom, Lucy E. Rayner, Lund, Luo, Manning, Marquart, Michaelsen, Narayanan, Paul A. Dalby, Perkins, Perkins, Perkins, Perkins, Phillips, Pilz, Radaev, Radaev, Rayner, Rayner, Remmele, Richard K. Heenan, Richardson, Roux, Saphire, Saphire, Sarma, Schneider, Schneidman-Duhovny, Schuck, Schuck, Semenyuk, Sondermann, Stephen J. Perkins, Strohl, Sun, Tamm, Tao, Thommesen, Wang, Yang   +79 more
core   +1 more source

In silico antibody engineering for SARS-CoV-2 detection

Computational and Structural Biotechnology Journal, 2021
Engineered immunoglobulin-G molecules (IgGs) are of wide interest for the development of detection elements in protein-based biosensors with clinical applications.
Didac Martí, Eduard Martín-Martínez, Juan Torras, Oscar Bertran, Pau Turon, Carlos Alemán   +5 more
doaj   +1 more source

IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design [PDF]

, 2017
Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules, which retain the specificity of the rodent antibody but ...
Angal, Bole, Borth, Breedveld, Chloe L. Stoyle, David P. Humphreys, Du, Durocher, Ellgaard, Feige, Feige, Freeze, Heath, Hendershot, Hendershot, Hu, Hubbard, Iwamoto, Katharine Cain, Leitzgen, Mains, Mason, Minegishi, Neil J. Bulleid, Nguyen, Paul E. Stephens, Peters, Sam Heywood, Schellenberger, Slanina, Spiess, Thies, Werther, Yang, Zou   +34 more
core   +1 more source