Results 201 to 210 of about 45,837 (320)

Clinical and Biochemical Factors Associated With Infliximab Pharmacokinetics in Adult Patients With Inflammatory Bowel Disease

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 1, January 2026.
Abstract Many patients with inflammatory bowel disease (IBD) do not adequately respond to infliximab, potentially due to individual differences in pharmacokinetics (PK). This study aimed to identify clinical and biochemical variables associated with infliximab PK.
Ilse A. Pool   +6 more
wiley   +1 more source

Optimising Monoclonal Antibody Drug Development for Inflammatory Bowel Disease. [PDF]

open access: yesClin Exp Gastroenterol
Colwill M   +3 more
europepmc   +1 more source

Spatial transcriptomics mapping of immune cell and TGFβ signalling pathway heterogeneity in testicular germ cell tumours

open access: yesAndrology, Volume 14, Issue 1, Page 210-227, January 2026.
Abstract Background Testicular germ cell tumours (TGCTs) are amongst the most common malignancies in young men, and their incidence is increasing worldwide. Tissue heterogeneity hampers efforts to understand how TGCT precursors (termed germ cell neoplasia in situ; GCNIS) emerge and progress, restricting elucidation of new strategies for diagnosis and ...
Sarah C. Moody   +6 more
wiley   +1 more source

Cold‐Induced Suppression of Myogenesis in Skeletal Muscle Stem Cells Contributes to Delayed Muscle Regeneration During Hibernation

open access: yesThe FASEB Journal, Volume 39, Issue 23, 15 December 2025.
Hibernating mammals preserve satellite cell viability during extreme cold exposure by suppressing ferroptosis through elevated GPX4 expression. Although these cells survive cold stress, myogenic activation and differentiation are markedly reduced, leading to delayed muscle regeneration in vivo.
Tatsuya Miyaji   +12 more
wiley   +1 more source

Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes

open access: yesChemElectroChem, Volume 12, Issue 24, December 8, 2025.
This work notably summarizes research on 2D MXenes/MXene's‐hybrid‐based nanoplatforms patterned with aptamers as an alternative to antibodies affording highly sensitive and robust biosensing of exosomes as well as their efficient isolation. The exosomes are highlighted as a valuable source of biomarkers and with the immobilization approaches of ...
Andrej Vikartovský   +5 more
wiley   +1 more source

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