Cystatin‐mediated enhancement of human epidermal growth factor bioproduction in plants
Human epidermal growth factor (EGF) fused with the protease inhibitor SlCYS8 and produced in plants showed enhanced stability, yield, and biological activity. This fusion strategy reduced degradation and outperformed commercial EGF in cell‐based assays, demonstrating a promising approach for producing stable, functional proteins in plant systems for ...
Hyun Ji Park+7 more
wiley +1 more source
Trispecific SEED antibodies engineered for neutrophil-mediated cell killing. [PDF]
Natale V+9 more
europepmc +1 more source
The paucity of small, skeletally immature individuals representing the earliest ontogenetic stages of extinct archosaurs complicates our understanding of the growth dynamics within and between species. The opportune finding of the smallest phytosaur femora reveals slow growth, a surprising signal considering that larger phytosaurs in North America have
Erika R. Goldsmith+6 more
wiley +1 more source
Nickel-Functionalized Nanoporous Heterostructure Microparticles for Immunoglobulin G Adsorption and Separation with High Efficiency. [PDF]
Zhang Y+5 more
europepmc +1 more source
Single-domain antibodies for brain targeting [PDF]
Lalatsa, Katerina, Moreira Leite, Diana
core +1 more source
ABSTRACT Background and Aims Hepatitis E virus (HEV) poses a significant global health concern, with millions of annual infections and a notable impact on public health. Although HEV is the leading cause of acute viral hepatitis worldwide, there is a substantial lack of approved and licensed vaccines. In this study, we evaluated the efficacy of several
Isabella Hrabal+12 more
wiley +1 more source
Molecular basis of Fab-dependent IgA antibody recognition by gut-bacterial metallopeptidases. [PDF]
Márquez-Moñino MÁ+13 more
europepmc +1 more source
Milk‐Derived Extracellular Vesicles and microRNAs: Potential Modulators of Intestinal Homeostasis
Upon ingestion, milk extracellular vesicles (EVs) carrying bioactive cargo like microRNAs and proteins may survive digestion and interact with intestinal epithelial cells via surface signaling or be internalized by intestinal epithelial cells to which they deliver their bioactive cargo.
Zeinab Husseini, Caroline Gilbert
wiley +1 more source
Effectiveness and safety of asfotase alfa for people with hypophosphatasia: a plain language summary of three studies. [PDF]
Jasmi FA, Belaya Z.
europepmc +1 more source
Current status and future prospects of cancer-derived immunoglobulins in pancreatic cancer. [PDF]
Ma R+8 more
europepmc +1 more source