Results 241 to 250 of about 732,598 (320)

A recombinant IgG1 Fc-domain protein ameliorates inflammatory demyelinating peripheral neuropathy. [PDF]

open access: yesFront Immunol
Otlu HG   +7 more
europepmc   +1 more source

Chemical characterisation of the Fab and Fc fragments from surface immunoglobulin

Nature, 1980
Immunoglobulin (Ig) molecules of the M and D classes are present on the membranes of B lymphocytes (sIg), where they serve as antigen receptors1–6. sIg is a biosynthetically stable membrane protein which requires either denaturing conditions or detergents to free it from other membrane constituents1,7–9.
R M, Parkhouse, J, Lifter, Y S, Choi
openaire   +3 more sources

Investigation of the Cooperative Structure of Fc Fragments from Myeloma Immunoglobulin G

Biochemistry, 1998
The cooperative structure of Fc fragments prepared from myeloma human IgG1 was studied using scanning microcalorimetry and fluorescence at pH 4.2-8.0. It was shown that the first to be melted are CH2 domains whose interaction with each other is rather weak, while that with CH3 domains is strong.
V M, Tischenko   +2 more
openaire   +3 more sources

Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1

Journal of Molecular Biology, 2007
Removal of the fucose residue from the oligosaccharides attached to Asn297 of human immunoglobulin G1 (IgG1) results in a significant enhancement of antibody-dependent cellular cytotoxicity (ADCC) via improved IgG1 binding to Fcgamma receptor IIIa. To provide structural insight into the mechanisms of affinity enhancement, we determined the crystal ...
Shigeki, Matsumiya   +8 more
openaire   +3 more sources

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