Anisotropic gold nanochains with dual-ligand interfaces for theranostic immune activation. [PDF]
Yang C +6 more
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A recombinant IgG1 Fc-domain protein ameliorates inflammatory demyelinating peripheral neuropathy. [PDF]
Otlu HG +7 more
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Mechanisms and applications of camelid variable heavy-chain nanobodies against bacterial and parasitic protozoal pathogens. [PDF]
Gattan HS, Alandijany TA.
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Redirecting TRIM21 with TRIMTACs for the targeted degradation of multimeric proteins. [PDF]
Scemama de Gialluly MA, Adams DJ.
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[Study of the lymphocytic receptor binding immunoglobulin G Fc fragment].
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Chemical characterisation of the Fab and Fc fragments from surface immunoglobulin
Nature, 1980Immunoglobulin (Ig) molecules of the M and D classes are present on the membranes of B lymphocytes (sIg), where they serve as antigen receptors1–6. sIg is a biosynthetically stable membrane protein which requires either denaturing conditions or detergents to free it from other membrane constituents1,7–9.
R M, Parkhouse, J, Lifter, Y S, Choi
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Investigation of the Cooperative Structure of Fc Fragments from Myeloma Immunoglobulin G
Biochemistry, 1998The cooperative structure of Fc fragments prepared from myeloma human IgG1 was studied using scanning microcalorimetry and fluorescence at pH 4.2-8.0. It was shown that the first to be melted are CH2 domains whose interaction with each other is rather weak, while that with CH3 domains is strong.
V M, Tischenko +2 more
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Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1
Journal of Molecular Biology, 2007Removal of the fucose residue from the oligosaccharides attached to Asn297 of human immunoglobulin G1 (IgG1) results in a significant enhancement of antibody-dependent cellular cytotoxicity (ADCC) via improved IgG1 binding to Fcgamma receptor IIIa. To provide structural insight into the mechanisms of affinity enhancement, we determined the crystal ...
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