Results 51 to 60 of about 243,158 (289)

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Fetal alloimmune thrombocytopenia and maternal intravenous immunoglobulin infusion

Haematologica, 2010
Background Different therapeutic approaches have been used in fetal-neonatal alloimmune thrombocytopenia, but many centers administer immunoglobulin G infusions to the pregnant woman.
Günther Giers, Folker Wenzel, Markus Stockschläder, Regina Riethmacher, Horst Lorenz, Boris Tutschek   +5 more
doaj   +1 more source

Surface plasmon resonance imaging detection of silver nanoparticle-tagged immunoglobulin [PDF]

, 2011
This article is available open access through the publisher’s website at the link below. Copyright @ 2011 The Royal Society.The detection sensitivity of silver nanoparticle (AgNP)-tagged goat immunoglobulin G (gIgG) microarrays was investigated by ...
Asim K. Ray, Deepen Paul, George R. Fern, Gosling J. P., Kretschmann E., Sharmistha Paul, Tscharnuter W.   +6 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Metabolism of Immunoglobulin-G in the Horse [PDF]

Acta Veterinaria Scandinavica, 1971
The metabolism of immunoglobulin classes has been closely examined in several animal species. Although the horse has received much attention in experimental and applied immunology there seems to be little information available on immunoglobulin kinetics in this species.
H.-J. Riising, Peter Nansen
openaire   +2 more sources

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source

Structural characterization of anti-inflammatory Immunoglobulin G Fc proteins [PDF]

, 2014
Immunoglobulin G (IgG) is a central mediator of host defense due to its ability to recognize and eliminate pathogens. The recognition and effector responses are encoded on distinct regions of IgGs.
Adams, Alysia A. Ahmed, Andrew Pincetic, Anthony, Anthony, Anthony, Anthony, Arnold, Barb, Crispin, Crispin, Diskin, Emsley, Evans, Evans, Feige, Ferrara, Frank, Gelfand, Huang, Jeffrey V. Ravetch, John Giddens, Joseph V. Lomino, Kaneko, Karplus, Krapp, Lai-Xi Wang, Leslie, Lund, Matsumiya, McCoy, Nimmerjahn, Nimmerjahn, Nimmerjahn, Nimmerjahn, Oganesyan, Oganesyan, Pamela J. Bjorkman, Samuelsson, Schrödinger, Schwab, Shibuya, Shields, Sondermann, Sprague, Tackenberg, Teplyakov, Yu   +47 more
core   +2 more sources

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Purification of rabbit polyclonal immunoglobulin G using anion exchangers. [PDF]

, 2011
Negative chromatography antibody purification (N-CAP) using the weak anion exchanger STREAMLINE™ DEAE to extract impurities while retaining the target antibody is proposed as an effective method for the recovery of antibody from rabbit serum. The effects
Ling, Tau Chuan, Subramaniam, Senthil Kumar, Taip, Farah Saleena, Tan, Wen Siang, Tey, Beng Ti, Wongchuphan, Rattana   +5 more
core   +1 more source