Results 81 to 90 of about 161,876 (218)

Immunoglobulin G4-related spinal pachymeningitis [PDF]

Saudi Medical Journal, 2020
Immunoglobulin G4-related disease (IgG4-RD) is rare disease entity and has recently been recognized as an inflammatory disorder with the tendency to affect multiple organs. Pachymeningitis of spine caused by IgG4-related disease is extremely rare.
openaire   +2 more sources

Supervised Protein Structure Classification Using Topological Persistence With DeltaFold

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Recent advances in protein structure prediction have considerably increased the number of available structures, underscoring the need for scalable and accurate methods to compare and classify this huge amount of data. Current approaches based on sequence alignment or structural superposition often lack sensitivity and/or are computationally ...
Joseph Nardin‐Gennequin, Gabriela Ciuperca, Céline Brochier‐Armanet, Philippe Malbos   +3 more
wiley   +1 more source

Orbital manifestations of immunoglobulin G4 disease

The Pan-American Journal of Ophthalmology
Herein, we report the case of a 59-year-old man presenting restriction in ocular motility, diplopia, proptosis, left eyelid ptosis, and a hardened mass in the frontotemporal zygomatic region, along with enlargement of the left parotid gland.
Gabriella Fouraux Gouvea, Beatriz De Moura Lucena, Lucas Pinheiro Machado Teles, Luiz Paulo Bastos Schmidt   +3 more
doaj   +1 more source

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

Immunoglobulin G4-related pleuritis - A case report [PDF]

, 2016
Immunoglobulin G4-related disease (IgG4-RD) is a chronic disease that presents with inflammation and fibrosis of involved tissue. It encompasses several disorders previously described using different terms, but all disorders are characterised by IgG4 ...
Rychwicka-Kielek, Beata A, Gajewska, Marta E, Kubik, Magdalena, Sørensen, Kathina, Rychwicka-Kielek, Beata A., Bendstrup, Elisabeth, Gajewska, Marta E., Hilberg, Ole   +7 more
core   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Immunoglobulin G4-Related Sclerosing Cholangitis

Journal of Digestive Diseases, 2019
Immunoglobulin (Ig)G4‐related sclerosing cholangitis (IgG4‐SC) is a biliary tract manifestation of IgG4‐related diseases (IgG4‐RD); a subgroup of SC defined as a condition with progressive stenosis and destruction of the bile ducts due to diffuse inflammation and fibrosis.
openaire   +3 more sources

Immunoglobulin G4 Related Lung Disease

Turkish Thoracic Journal, 2020
Immunoglobulin G4 related disease (IgG4-RD) is a relatively newly defined disease known for multiple organ involvement. Histopathologically, the disease is characterized by lymphoplasmatic inflammation, fibrosis, and enhanced levels of IgG4-positive plasma cells in tissues. IgG4-RD has been reported in almost every organ system.
Ekrem Cengiz, Seyhan, Mehmet Akif, Özgül, Efsun, Uğur, Demet, Turan, Nur, Ürer   +4 more
openaire   +2 more sources

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

Immunoglobulin G4 related disease isolated to the nasal cavity: a rare cause of nasal obstruction

, 2015
Background: Immunoglobulin G4 related disease is a rare condition. Cases involving the sinonasal region are exceptionally uncommon. This paper describes a case of immunoglobulin G4 related disease isolated solely to the nasal cavity. Methods: Case report
Singh, Narinder Pal, Morris, Christopher G., Ng, Thomas, Kevin, Punarja   +3 more
core   +1 more source