Results 171 to 180 of about 218 (190)

Gene segments encoding transmembrane carboxyl termini of immunoglobulin γ chains

Cell, 1981
In cell lines producing IgM, secreted and membrane bound forms of immunoglobulin mu heavy chains are produced from two separate mu mRNAs that are identical except for alternative 3' coding sequences. We now show that cell lines producing IgG likewise contain two mRNA species for immunoglobulin gamma chains.
Carla Carter, Edmund Chol, David Eisenberg, Lawrence M. Souza, John M. Rogers, Michael Kuehl, Charlotte Word, Randolph Wall   +7 more
openaire   +3 more sources

Human Immunoglobulin A Receptor (FcRI, CD89) Function in Transgenic Mice Requires Both FcR γ Chain and CR3 (CD11b/CD18) [PDF]

Blood, 1999
AbstractEven though more immunoglobulin A (IgA) is produced in humans than all other isotypes combined, relatively little is known about receptors that bind the Fc part of IgA. The myeloid IgA receptor, FcRI (CD89), triggers various effector functions in vitro, but its in vivo role remains unclear.
Annemiek B. van Spriel, Marjolein van Egmond, Tanya N. Mayadas, Li Shen, Jan G. J. van de Winkel, Frans M. A. Hofhuis, Takashi Saito, J. Sjef Verbeek, H. Craig Morton, A.J. Hanneke van Vuuren   +9 more
openaire   +3 more sources

Cloning and characterization of cDNAs encoding four different canine immunoglobulin γ chains

Veterinary Immunology and Immunopathology, 2001
cDNAs encoding four different canine immunoglobulin G (caIgG) gamma chains were identified in this study. One of these IgG gamma chain cDNAs, (caIgG-A), represents 92.5% of the IgG gamma chain cDNAs in a dog spleen cell cDNA library; a second partial IgG gamma chain cDNA (caIgG-B) was also identified in the library. The other two IgG gamma chain cDNAs (
Catherine McCall, Liang Tang, Matthew J. Dreitz, Craig Sampson   +3 more
openaire   +3 more sources

Heterogeneity of Heavy (γ) Chain Preparations from Human γG-Immunoglobulins

Nature, 1966
IN recent publications, Cohen1 and Cohen and Porter2 have presented evidence that light chain preparations from partially reduced and iodoacetamide-alkylated γ-globulins of several species are heterogeneous. In glycine-urea starch-gel electrophoresis, pH 7–8, some eight to ten electrophoretically distinct bands were separated.
openaire   +3 more sources

Vectors for Expression of Signal Peptide-Dependent Proteins in Baculovirus/Insect Cell Systems and Their Application to Expression and Purification of the High-Affinity Immunoglobulin Gamma Fc Receptor I in Complex with Its Gamma Chain

Molecular Biotechnology, 2017
Integral membrane proteins play a central role in various cellular functions and are important therapeutic targets. However, technical challenges in the overexpression and purification of membrane proteins often represent a limiting factor for biochemical and structural studies.
Jens R. Nyengaard, Jens R. Nyengaard, Le T. M. Le, Monika M. Golas, Monika M. Golas, Bjoern Sander, Bjoern Sander   +6 more
openaire   +3 more sources

TWO SEPARATE NON‐IMMUNE INTERACTIONS BETWEEN STAPHYLOCOCCAL PROTEIN A AND IMMUNOGLOBULINS ARE MEDIATED BY STRUCTURES ON γ CHAINS

Acta Pathologica Microbiologica Scandinavica Series B: Microbiology, 1986
The present investigation was undertaken to determine whether the light or the heavy immunoglobulin chain is involved in the alternative, non‐immune F(ab')2‐mediated binding to staphylococcal protein A. Purified human polyclonal IgG was mildly reduced with dithiothreitol and alkylated with iodoacetamide.
Mats Erntell, Erling B. Myhre, Göran Kronvall   +2 more
openaire   +3 more sources

Localization of Immunoglobulin G γ-Chain mRNA-Expressing Cells in the Oviduct of Laying and Diethylstilbestrol-Treated Immature Hens

General and Comparative Endocrinology, 2000
The purpose of this study was to determine the synthetic sites of IgG in the chicken oviduct by localizing IgG gamma-chain mRNA (IgGgamma mRNA)-expressing cells and the effects of estrogen on their population. Paraffin sections of oviducal tissues from laying hens (approximately 57 weeks old) and immature hens (approximately 16 weeks old) with or ...
J. Izaki, Yukinori Yoshimura, Shuichi Furusawa, Weiming Zheng   +3 more
openaire   +3 more sources

Presentation of ovalbumin internalized via the immunoglobulin-A Fc receptor is enhanced through Fc receptor γ-chain signaling

Blood, 2001
AbstractThe mechanism of enhanced presentation of ovalbumin (OVA) internalized as immunoglobulin A (IgA)–OVA via the IgA Fc receptor (FcαR) was analyzed by focusing on the role of the FcαR-associated γ chain. Comparison of B-cell transfectants expressing FcαR plus wild-type (WT) γ chain or γ chain in which the immunoreceptor tyrosine-based activation ...
Hong Gao, Hong Gao, Marcus R. Clark, Marcus R. Clark, Li Shen, Li Shen, Mark L. Lang, Mark L. Lang, William F. Wade, William F. Wade, Marjolein van Egmond, Marjolein van Egmond, Terri K. Wade, Terri K. Wade, Karyn Siemasko, Karyn Siemasko, Jan G. J. van de Winkel, Jan G. J. van de Winkel   +17 more
openaire   +3 more sources

The membrane exons of the pseudo-γ-chain gene of the human immunoglobulin are apparently functional and highly homologous to those of the γ1 gene

Immunology Letters, 1991
Nucleotide sequences of the membrane exons of human immunoglobulin pseudo-gamma gene and gamma 1 chain cDNA were determined and compared. The sequences of the membrane exons of the pseudo-gamma gene had no defective mutations in the coding regions or the exon-intron boundaries.
Kazuo Kinoshita, Akira Shimizu, Tasuku Honjo   +2 more
openaire   +3 more sources

Cell surface immunoglobulin μ and γ chains of human lymphoid cells are of higher apparent molecular weight than their secreted counterparts

European Journal of Immunology, 1980
AbstractSelected human lymphoma‐derived and lymphoblastoid cell lines have been characterized and shown to be useful model systems for the expression of either cell surface Ig, or secretory Ig, or both simultaneously. Daudi and Raji cell lines were shown to express surface IgM with no secretion of IgM.
A. R. Williamson, Paul A. Singer
openaire   +3 more sources