Results 221 to 230 of about 116,527 (269)
Small Science, EarlyView.In this study, a proof of concept is presented using an extended‐gate field‐effect‐transistor biosensing platform for monitoring immunotherapeutic drugs in vivo. Using varying sizes of immunotherapeutic drugs, the biosensor surpasses the sensitivity of standard methods, reducing the need for radioactive labeling in real‐time sensing.
Trang‐Anh Nguyen‐Le +8 more
wiley +1 more source
Small Science, EarlyView.Triggered by electrostatic interactions and stabilized by H bonding and π–π stackings, Fmoc‐FFpY/Fe3+ self‐assembles into β‐sheets twisted into 12 nm diameter fibrillar helices. In full agreement with molecular dynamic simulations, the resulting injectable hydrogels have antibacterial activity by ferroptosis, enhanced production of reactive oxygen ...
Capucine Loth +11 more
wiley +1 more source
Small Methods, EarlyView.“Pentagon” in carbon framework is focused in this review, although hexagon is standard atomic frames in carbon materials. This review elucidates the fundamental principles governing pentagon‐related activity and offers perspectives on future directions for designing efficient oxygen reduction reaction catalysts based on carbon materials ...
Guoping Chen +3 more
wiley +1 more source
Small Structures, EarlyView.The constant fragment (Fc) of the immunoglobulin G1 (IgG1) subtype is a widely used scaffold for designing advanced therapeutics. Herein, together with the integration of experimental and computational techniques, this study reveals the structural dynamics of the N‐glycan‐bound Fc fragment of IgG1 from VEGF‐Trap, providing a new insight into enhancing ...
Ebru Destan +11 more
wiley +1 more source
Structure of the Fab fragment of a humanized 5E5 antibody to a cancer‐specific Tn‐MUC1 epitope
Acta Crystallographica Section D, EarlyView.The structure of the humanized Fab from murine monoclonal antibody 5E5 specific for tumor antigen Tn‐MUC1 has been determined to 1.57 Å resolution. The humanization process has imposed changes in the framework regions of the Fv which may have affected the Vh–Vl interface.The structure of the humanized Fab from murine monoclonal antibody 5E5 specific ...
Wei Li +7 more
wiley +1 more source
Aging Cell, EarlyView.Age‐related differences in EAE outcomes stem from combined peripheral and CNS factors. Key peripheral adaptive immunity changes include altered naïve/memory T cell ratios, Th1 skewing, increased suppressive Tregs, CD4+ T cell exhaustion, enhanced B cell antigen presentation, and reduced NK cell cytotoxicity.
María Dema +6 more
wiley +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To provide an overview of artificial tears marketed in the following Nordic countries: Denmark, Finland, Norway, Iceland and Sweden. Furthermore, this review aimed to highlight the different preservatives and other constituents found in artificial tears in the Nordic market, focussing on adverse effects.
K. N. Mikha +9 more
wiley +1 more source
A new conservative and robust Bayesian approach for the event date model in chronology building
Archaeometry, EarlyView.Abstract Dating techniques in archaeology have undergone considerable development in recent decades. Today, the major challenge for archaeologists remains the reliability and precision of the date attributed to an artefact or an archaeological event. To this end, it is essential for archaeologists to cross‐reference information from different sources ...
Komlan Midodzi Noukpoape +2 more
wiley +1 more source