Results 311 to 320 of about 130,645 (352)

Origins of immunoglobulin heavy chain domains

Journal of Molecular Evolution, 1980
Using computer programs that analyze the evolutionary history and probability of relationship of protein sequences, we have investigated the gene duplication events that led to the present configuration of immunoglobulin C regions, with particular attention to the origins of the homology regions (domains) of the heavy chains.
W C, Barker, L K, Ketcham, M O, Dayhoff
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Whale immunoglobulins—II. Heavy chain structure

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1972
Abstract 1. 1. Immunoglobulins (7S) were purified from the plasmas of three species of whales, hump-backed, fin-backed and Sei. 2. 2. Heavy polypeptide chains were characterized and compared to human γ chains. 3. 3. Amino acid composition and peptide map comparisons indicated much homology between the whale 7S Ig heavy chain and hyman γ.
J C, Travis, B G, Sanders
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Rat immunoglobulin E heavy chain locus

Journal of Molecular Biology, 1984
A 2100 base-pair long sequence has been established which covers all four constant domains of the rat epsilon-chain. An analysis of messenger RNA from an immunoglobulin E producing rat immunocytoma revealed two separate epsilon-chain mRNA species, 2.3 X 10(3) and 2.8 X 10(3) base-pairs long.
M L, Steen, L, Hellman, U, Pettersson
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Immunoglobulin heavy-chain loci in ancient allotetraploid goldfish

Developmental & Comparative Immunology, 2022
As an ancient allotetraploid species, goldfish (Carassius auratus) have two sets of subgenomes. In this study, immunoglobulin heavy-chain (IGH) genes were cloned from the red crucian carp (Carassius auratus red var.), and the corresponding loci were identified in the gynogenetic diploid red crucian carp (GRCC) genome as well as the genomes of three ...
Linmei, Han, Jihong, Li, Wen, Wang, Kaikun, Luo, Mingli, Chai, Caixia, Xiang, Ziye, Luo, Li, Ren, Qianhong, Gu, Min, Tao, Chun, Zhang, Jing, Wang, Shaojun, Liu   +12 more
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Regulation of immunoglobulin heavy‐chain gene rearrangements

Immunological Reviews, 2004
Summary:  Regulated assembly of antigen receptor gene segments to produce functional genes is a hallmark of B‐ and T‐lymphocyte development. The immunoglobulin heavy‐chain (IgH) and T‐cell receptor β‐chain genes rearrange first in B and T lineages, respectively.
Dipanjan, Chowdhury, Ranjan, Sen
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Immunoglobulin heavy-chain constant-region genes

Cell, 1982
Antibodies are composed of two identical heavyand light-chain polypeptides. Each heavy and light chain contains an amino-terminal variable (V) region, responsible for antigen recognition, and a carboxy-proximal constant(C) region, which participates in a variety of immunological processes, including effector-cell recognition and complement fixation ...
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Immunoglobulin heavy-chain switching in pre-B leukaemias

Nature, 1983
Immunoglobulin gene expression is initiated in pre-B cells by rearrangements of heavy-chain variable genes V, D and J, for transcription together with the constant region gene C mu (refs 1-7). The subsequent joining of light-chain V-J genes in the kappa or lambda families leads to formation of complete IgM molecules, which are then expressed on the ...
H, Kubagawa, M, Mayumi, W M, Crist, M D, Cooper   +3 more
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Amino terminal sequences of human immunoglobulin heavy chains

Immunochemistry, 1971
Abstract Partial amino-terminal sequences of 6γ, 5μ and 2α human Ig heavy chains not previously described, are presented. These sequences in conjunction with data on 28 other heavy chains permit further definition of heavy chain variable region subgroups.
A P, Kaplan, L E, Hood, W D, Terry, H, Metzger   +3 more
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Hypervariable Region of Human Immunoglobulin Heavy Chains

Nature New Biology, 1971
THE variable regions of human immunoglobulin light chains contain three areas of unusually high variability1–4. Similar hypervariable regions have been postulated for human heavy chains5, 6, but there are no amino-acid sequence data to support this idea.
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J Genes for Heavy Chain Immunoglobulins of Mouse

Science, 1980
A 15,8-kilobase pair fragment of BALB/c mouse liver DNA, cloned in the Charon 4Aλ phage vector system, was shown to contain the μ heavy chain constant region (C H μ) gene for the mouse immunoglobulin M. In addition, this fragment of DNA contains at least two J genes, used to code for the carboxyl terminal portion of
Newell, N, Richards, J E, Tucker, P W, Blattner, F R   +3 more
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