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Organization of the Human Immunoglobulin Heavy-Chain Locus
1996Immunoglobulin (Ig) heavy-chain (H) genes cluster at three loci in the human genome; the distal region of chromosome 14(1), chromosome 15(2) and chromosome 16(3). Among these only the chromosome 14 locus has been shown to generate a functional Ig gene by recombination of the variable (VH), diversity (D) and joining (JH) segments.
F, Matsuda, T, Honjo
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Immunoglobulin Heavy Chain Can Be Amyloidogenic
The American Journal of Surgical Pathology, 2003It is not well recognized that monoclonal immunoglobulin heavy chains or their fragments can be amyloidogenic. Amyloidosis due to heavy chains, referred to as AH amyloidosis, is rare with only three cases previously reported. An additional case of AH amyloidosis is reported.
Hoa L, Mai +4 more
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International Journal of Immunogenetics, 1976
SUMMARYThe mobilities of murine splenocyte surface immunoglobulin heavy chains were compared by polyacrylamide gel electrophoresis in SDS‐containing buffers, with those of the heavy chains of human IgM, IgG, and IgD, and toad IgY. Human δ‐chain showed a mobility only slightly faster than that of human μ‐chain, and required double‐labelling techniques ...
Warr, G W, Marchalonis, J J
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SUMMARYThe mobilities of murine splenocyte surface immunoglobulin heavy chains were compared by polyacrylamide gel electrophoresis in SDS‐containing buffers, with those of the heavy chains of human IgM, IgG, and IgD, and toad IgY. Human δ‐chain showed a mobility only slightly faster than that of human μ‐chain, and required double‐labelling techniques ...
Warr, G W, Marchalonis, J J
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Biological variation of immunoglobulin heavy chain-light chain pairs in serum
Clinica Chimica Acta, 2014Assays for immunoglobulin heavy chain-light chain (HLC) pairs called Hevylite® have recently been developed. These assays can be useful in patients with hard to interpret serum protein electrophoresis peaks. Measurement of the biological variation of clinical laboratory tests can help clinicians better interpret laboratory results.Serum samples were ...
Judith A, Finlay, Alan H B, Wu
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Amyloid, 2001
The Congo red-binding fibrils of AL amyloidosis are the most common form of monoclonal immunoglobulin tissue deposition (MIDD). Nonetheless, the less structured deposits found in light chain deposition disease (LCDD) and the similar, but distinct, deposits of light and heavy chain deposition disease (LHCDD) and heavy chain deposition disease (HCDD) can
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The Congo red-binding fibrils of AL amyloidosis are the most common form of monoclonal immunoglobulin tissue deposition (MIDD). Nonetheless, the less structured deposits found in light chain deposition disease (LCDD) and the similar, but distinct, deposits of light and heavy chain deposition disease (LHCDD) and heavy chain deposition disease (HCDD) can
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Chapter 5 Immunoglobulin heavy chain class switching
1987Publisher Summary Whilst the variable region of an immunoglobulin molecule carries the antigen binding site and regulatory idiotypic determinants, the constant region is responsible for the effector functions of the molecule. These functions include transmembrane signalling and secretion signals, agglutination of antigens, complement activation and ...
U. Krawinkel, A. Radbruch
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Immunoglobulin gene alterations in human heavy chain diseases
Research in Immunology, 1989M, Cogné +2 more
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Two Forms of Loops Generate the Chromatin Conformation of the Immunoglobulin Heavy-Chain Gene Locus
Cell, 2011Tatiana Gerasimova +2 more
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