Results 111 to 120 of about 136,376 (331)

Controlled Growth of Graphene‐Skinned Al2O3 Powders by Fluidized Bed‐Chemical Vapor Deposition for Heat Dissipation

open access: yesAdvanced Science, EarlyView.
This research introduces a facile and scalable FB‐CVD strategy for synthesizing high‐crystallinity, multilayer Gr‐skinned Al2O3 powders, specifically designed for advanced thermal management applications. The continuous graphene skin establishes a comprehensive heat transfer network, ensuring efficient heat dissipation.
Yuzhu Wu   +27 more
wiley   +1 more source

AntiBMPNN: Structure‐Guided Graph Neural Networks for Precision Antibody Engineering

open access: yesAdvanced Science, EarlyView.
AntiBMPNN, a deep learning framework that integrates antibody‐specific 3D data, MPNN, frequency‐based scoring, and AlphaFold 3, achieves superior antibody sequence design. In most cases, it outperforms ProteinMPNN, AntiFold, and AbMPNN in CDR design, demonstrating higher binding affinities and sequence recovery.
Ze‐Yu Sun   +13 more
wiley   +1 more source

In-Cell Assembly of scFv from Human Thyroid- Infiltrating B Cells

open access: yesBioTechniques, 1997
The construction of a large library of single-chain Fv (scFv) antibody fragments involves a random assortment of heavy and light chains. Although useful for the production of recombinant antibodies, this method is not adapted to the study of the ...
N. Chapal   +6 more
doaj   +1 more source

Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease

open access: yesAdvanced Science, EarlyView.
In this study, an adaptive antioxidant nanodrug (AAN) is developed through the self‐polymerization of L‐selenocysteine. The AAN exhibits dual functionalities: antioxidant activity (scavenging reactive oxygen species) and mitochondrial targeting. Moreover, the released selenium (Se) participates in the synthesis of glutathione peroxidase 4 (GPX4), which
Zerun Liu   +15 more
wiley   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

open access: yesAdvanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang   +12 more
wiley   +1 more source

Immunoglobulin Isotypes in Atlantic Salmon, Salmo Salar

open access: yesBiomolecules, 2015
There are three major immunoglobulin (Ig) isotypes in salmonid fish: IgM, IgD and IgT, defined by the heavy chains μ, δ and τ, respectively. As a result of whole genome duplication in the ancestor of the salmonid fish family, Atlantic salmon (Salmo salar)
Ivar Hordvik
doaj   +1 more source

Biosynthetic units of an immunoglobulin heavy chain. [PDF]

open access: yesProceedings of the National Academy of Sciences, 1967
Knopf, P M, Parkhouse, R M, Lennox, E S
openaire   +3 more sources

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

open access: yesAdvanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng   +9 more
wiley   +1 more source

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