Results 161 to 170 of about 62,488 (307)

The Immunoglobulin Heavy Chain Locus of the Duck [PDF]

Journal of Biological Chemistry, 2001
Mats L. Lundqvist, Darlene L. Middleton, Starr Hazard, Gregory W. Warr   +3 more
openaire   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Multimodal Chromatography in the Downstream Processing of mAb‐Based Products: Mechanisms, Strategies, and Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Multimodal chromatography has emerged as a powerful tool for the purification of monoclonal antibodies (mAbs) and their derivatives—including antibody fragments (Fabs), Fc‐fusions, bispecific (BsAb), and antibody–drug conjugates (ADCs)—offering enhanced selectivity through the integration of ionic, hydrophobic, hydrogen‐bonding, and π–π ...
Amin Javidanbardan, Marco P․ C․ Marques, Ana M. Azevedo, Daniel G. Bracewell, Stephen Goldrick   +4 more
wiley   +1 more source

Engineered Bacterial Ligand From Streptococcus pneumoniae on Macroporous Resins for Selective Affinity Capture of Secretory IgA

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Secretory immunoglobulin A (sIgA) is a promising emerging biopharmaceutical candidate, but it currently lacks a standardized platform for purification. To address this, a novel affinity chromatography resin was developed by immobilizing protein variants of the Streptococcus pneumoniae surface protein, SpsA, as an affinity ligand.
David Scheich, Andres Männik, Oliver Meikar, Joan Teyra, Laura Kibena, Sebastiaan Eeltink, Rainer Hahn, Alois Jungbauer, Nico Lingg   +8 more
wiley   +1 more source

Engineered B7‐H3 Binding in Modular Gp2 Miniproteins

Biotechnology and Bioengineering, EarlyView.
ABSTRACT B7‐H3, an important immune checkpoint modulator of T‐cell function, is a tumor vasculature biomarker and is overexpressed in a variety of cancers. Its expression is associated with tumor growth, metastasis, and poor clinical prognosis, which makes B7‐H3 an appealing target for diagnostics and therapeutics.
Abbigael Harthorn, Hannah K. Windsor, Zachary Schmitz, Nathaniel Cheung, Ebube Agwaramgbo, Benjamin J. Hackel   +5 more
wiley   +1 more source

Effect of Precursor Structure on Pore Evolution of Pitch‐Derived Porous Carbon Nanoarchitectonics

Carbon and Hydrogen, EarlyView.
Precursor microstructure–regulated activation and pore evolution in pitch‐derived porous carbon, demonstrating the superior nanoarchitectonics at moderate mesophase content. ABSTRACT Developing high‐performance porous carbons (PCs) requires precise microstructural control, which can be effectively understood within the framework of nanoarchitectonics ...
Yajie Duan, Keyan Xu, Yichao Zou, Rujun Zha, Hao Ling   +4 more
wiley   +1 more source

Organization and Reorganization of Immunoglobulin Heavy-chain Genes

Cold Spring Harbor Symposia on Quantitative Biology, 1981
T, Honjo, T, Kataoka, Y, Yaoita, A, Shimizu, N, Takahashi, Y, Yamawaki-Kataoka, T, Nikaido, S, Nakai, M, Obata, T, Kawakami, Y, Nishida   +10 more
openaire   +2 more sources

Engineering Biochar‐Derived Functional Materials for High‐Performance Supercapacitors: Design Principles, Mechanisms, and Scalable Strategies

Carbon Energy, EarlyView.
ABSTRACT Biochar has emerged as a useful and adaptable source of carbon for supercapacitor electrodes. Its value comes from the way biomass chemistry, thermal conversion, and activation conditions shape the resulting pore network, surface groups, and degree of carbon ordering.
Soumen Mandal, Avinash C. Mendhe, Mayna Roy, Neha S. Barse, Taejoon Park, Han‐Seung Lee, Haigun Lee   +6 more
wiley   +1 more source

Energy‐Efficient Induction Carbonization: Tailoring Pore Structures in Hard Carbon Anodes Toward Enhanced Electrochemical Performance

Carbon Energy, EarlyView.
ABSTRACT Hard carbon (HC) is currently the predominant anode material for sodium‐ion batteries; however, its practical application is still limited by insufficient initial Coulombic efficiency (ICE) and plateau capacity. Meanwhile, conventional HC production relies on energy‐intensive carbonization processes with considerable carbon emissions. Here, an
Yanghao Jin, Mengwei Sun, Ziyi Shi, Dumindu Pasan Siriwardena Thanaweera Achchige, Huiting Liu, Hanmin Yang, Yaprak Subasi, Ritambhara Gond, Yazhe Wang, Habtom Desta Asfaw, Yun Tian, Manuel Baumann, Marcel Weil, YongGang Yao, Haiping Yang, Reza Younesi, Pär G. Jönsson, Weihong Yang, Tong Han   +18 more
wiley   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source