Results 161 to 170 of about 35,294 (257)

The Growth Supporting Role of ZDHHC11 Is Linked to the MEF2B–BCL6 Regulatory Circuit in Burkitt Lymphoma

International Journal of Cancer, EarlyView.
MEF2B and BCL6 have established functions in germinal center B‐cell biology and lymphomagenesis. The mechanism of MEF2B deregulation and its significance for cell survival in Burkitt lymphoma however remain unclear. This study highlights MEF2B as a crucial transcription factor in Burkitt lymphoma and suggests ZDHHC11 as an upstream regulator of MEF2B ...
Lotteke J. Y. M. Ziel‐Swier, Karolina Rassek, Yichen Liu, Annika Seitz, Jasper Koerts, Debora de Jong, Bea Rutgers, Anastasiia Kompaniiets, Julia Przybył, Martine E. D. Chamuleau, Anke van den Berg, Agnieszka Dzikiewicz‐Krawczyk, Joost Kluiver   +12 more
wiley   +1 more source

Identification of gene conversion events in horse IGHV suggests preferential hotspots for diversification. [PDF]

Immunogenetics
Pinto JEL, Gervásio JHB, Ng JC, Gomes-Silva A, de Matos Guedes HL, Cunha L, Castilho LR, da Silva JL, Franco GR, Navas C, Felicori LF.   +10 more
europepmc   +1 more source

Early‐Life Exposures and Risk of Multiple Myeloma: A Population‐Based Case–Control Study in Australia

International Journal of Cancer, EarlyView.
Early‐life exposures may influence immune system development and, in turn, affect cancer susceptibility. In this population‐based case‐control study, the authors examined whether in utero or early childhood exposures were associated with the risk of developing multiple myeloma in adulthood.
Zhuoyu Sun, Julie K. Bassett, Simon Cheah, Fiona J. Bruinsma, Wendy Cozen, Simon J. Harrison, H. Miles Prince, Nicole Wong Doo, Graham G. Giles, Roger L. Milne, Brigid M. Lynch   +10 more
wiley   +1 more source

Polyclonal Antibody Therapeutics: Analytical Innovations and Regulatory Perspectives for Addressing Heterogeneity Challenges. [PDF]

Anal Chem
Kumar S, Tini A, Tengattini S, Rinaldi F, Calleri E, Massolini G, Temporini C.   +6 more
europepmc   +1 more source

The formation of pyrrolid-2-one-5-carboxylic acid at the N-terminus of immunoglobulin G heavy chain

, 1972
We propose that pyrrolid-2-one-5-carboxyl-tRNA is not involved in the initiation of protein synthesis in eukaryotic cells and that the <i>N</i>-terminal pyrrolid-2-one-5-carboxylic acid group of an IgG (immunoglobulin G) (that secreted by the
Munro, A.J., Stott, D.I.
core  

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

Complete and Rapid NMR Characterization of Therapeutic Monoclonal Antibodies via Differential Labeling of Fab Fragments in <i>Escherichia coli</i>. [PDF]

Anal Chem
Gagné D, Aubin Y.
europepmc   +1 more source

Pseudohyperphosphatemia in Multiple Myeloma: A Systematic Review of Case Reports and Case Series

Journal of Clinical Laboratory Analysis, EarlyView.
Pseudohyperphosphatemia (PHP) is a clinically significant laboratory artifact in patients with multiple myeloma (MM). It is often caused by paraprotein interference with phosphate assays. This systematic review summarizes reported cases, underlying mechanisms, and diagnostic approaches to distinguish spurious from true hyperphosphatemia.
Mahsa Dabir, Maryam Kamrani Mousavi, Mohana Mohamadi, Ali Maleki   +3 more
wiley   +1 more source

Executive summary of the European consensus report on the diagnosis and treatment of monoclonal gammopathy of renal significance. [PDF]

Clin Kidney J
Sprangers B, Cohen C, Gnemmi V, Shabaka A, Fernandez-Juarez G, van Midden D, Steenbergen E, Milani P, Vignon M, Wilde B, Hegenbart U, Wetzels JF.   +11 more
europepmc   +1 more source

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source