Results 171 to 180 of about 1,441,564 (292)

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Overcoming the Limitations of Protein A: Evolution of Bacterial Protein-Based and Synthetic Affinity Ligands for High-Performance IgG Purification. [PDF]

Int J Mol Sci
Ikryannikova LN, Tereshin MN, Baskova MV, Telepenina KP, Gorokhovets NV, Bayzigitov DR, Gurylina EA, Stepanenko VN, Melikhova TD.   +8 more
europepmc   +1 more source

Antibody kinetics against tetanus toxoid before and after primary vaccination of foals

Equine Veterinary Journal, EarlyView.
Abstract Background Vaccination recommendations for foals against Clostridium tetani vary. Available studies assessing foal immune responses, maternal antibody interference, or individual variation often used small foal numbers. Objectives To quantify antibody responses after tetanus vaccination in foals and explore associations with passively ...
Katharina Olbrich, Monica Venner, Bettina Wagner   +2 more
wiley   +1 more source

Analysis of Surface Immunoglobulin Expression in Burkitt Lymphoma Reveals a Subset of IgA-Expressing Cases Enriched at Mucosal Sites and Surface Immunoglobulin-Undetectable Cases: Insights into the Mutational Landscape. [PDF]

Cancers (Basel)
Siciliano MC, Lori C, Vannucchi M, Amato T, Bertolazzi G, Guazzo R, Noel O, Onyuma T, Granai M, Boccacci R, Grace K, Peter O, Onsongo S, Georgina M, Wedaga SP, Foster K, Mildred H, Joshua N, Fischer A, Bellan C, Siebert R, Leoncini L, Lazzi S.   +22 more
europepmc   +1 more source

ER‐Localized Deadenylase PNLDC1 Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of TUBB4B

Exploration, EarlyView.
The deficiency of PNLDC1 exacerbates the advancement of CRC. PNLDC1 interacts with TUBB4B mRNA to regulate the p53–p21–CDK2–cyclin E2 pathway, thereby influencing the G2/M phase of the cell cycle. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies.
Lexin Liu, Yuelin Guan, Yuzhou Qin, Guiping Chen, Guozhen Wang, Xiang Yan, Xue Li, Lei Sun, Wei Yu, Shi Ouyang, Zhichao Ma, Zihao Xu, Zhongkai Cao, Fan Yu, Tong Zhou, Ziyou Luo, Xiangjun Chen, Yongbin Yan, Lidan Hu   +18 more
wiley   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Antibodies targeting a shared epitope exploit IgE allostery to drive distinct functional outcomes. [PDF]

Proc Natl Acad Sci U S A
Davies AM, Drinkwater N, Beavil AJ, O'Dowd V, Lightwood D, Ceska T, Henry AJ, Sutton BJ, McDonnell JM.   +8 more
europepmc   +1 more source

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source

Discovery of human antibody specific to the spike glycoprotein subunit 2 of SARS-CoV-2 and characterization of its broad-spectrum neutralizing activity. [PDF]

Infect Med (Beijing)
Chi Y, Yin H, Huang C, Ge Y, Liu J, Ding Y, Shi F, Cui Z, Ning S, Jiao Y, Cui L.   +10 more
europepmc   +1 more source

Plasma Proteomic Profiling Reveals Alterations in Coagulation, Complement, and Extracellular Matrix Pathways in Orthostatic Hypotension. [PDF]

JACC Adv
Johansson M, Végvári Á, Engström G, Fedorowski A.   +3 more
europepmc   +1 more source