Results 11 to 20 of about 1,441,564 (292)

Distribution of immunoglobulin heavy chains in diseased synovia.

, 1986
Synovium from 142 patients with 12 different arthropathies was examined for the distribution of alpha, delta, gamma, and mu immunoglobulin heavy chains.
Rutley, C., Freemont, AJ; id_orcid
core   +10 more sources

Individual B cells transcribe multiple rearranged immunoglobulin light chains in teleost fish

iScience, 2021
Summary: B cells express a unique antibody protein which comprises two pairs of immunoglobulin (Ig) heavy (H) and light (L) chains. In addition to an invariable constant (C) region, IgH and IgL chains encompass a variable (V) region mediating antigen ...
Pedro Perdiguero, Esther Morel, Patricia Díaz-Rosales, Carolina Tafalla   +3 more
doaj   +2 more sources

Using cell-free RNA to identify B- and T-cell clonality for diagnosis and monitoring of B- and T-cell neoplasms. [PDF]

FEBS Open Bio
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Albitar A, Agersborg S, Charifa A, Phull P, Biran N, Vesole D, Parmar H, Pecora A, Ip A, Goy A, Siegel D, Albitar M.   +11 more
europepmc   +2 more sources

ALLOTYPE EXPRESSION BY THREE LINKED GENES CODING FOR THE VARIABLE REGION OF RABBIT IMMUNOGLOBULIN HEAVY CHAINS.

, 1973
ALLOTYPE EXPRESSION BY THREE LINKED GENES CODING FOR THE VARIABLE REGION OF RABBIT IMMUNOGLOBULIN HEAVY ...
BYUNG-SUK. KIM (7977689)
core   +6 more sources

Learning the statistics and landscape of somatic mutation-induced insertions and deletions in antibodies.

PLoS Computational Biology, 2022
Affinity maturation is crucial for improving the binding affinity of antibodies to antigens. This process is mainly driven by point substitutions caused by somatic hypermutations of the immunoglobulin gene.
Cosimo Lupo, Natanael Spisak, Aleksandra M Walczak, Thierry Mora   +3 more
doaj   +1 more source

Mu heavy chain disease with MYD88 L265P mutation: an unusual manifestation of lymphoplasmacytic lymphoma

Diagnostic Pathology, 2022
Background Mu heavy chain disease is a rare lymphoid neoplasm characterized by vacuolated bone marrow plasma cells and secretion of defective mu immunoglobulin heavy chains. The biological basis of mu heavy chain disease is poorly understood.
Vandana Baloda, Sarah E. Wheeler, David L. Murray, Mindy C. Kohlhagen, Jeffrey A. VosUPMC, Svetlana A. Yatsenko, Mounzer E. Agha, Miroslav Djokic, Steven H. Swerdlow, Nathanael G. Bailey   +9 more
doaj   +1 more source

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Schwirzke, Marina, Kaluzab, Brigitte, Weissenhorn, Winfried, Weiss, Elisabeth H., Weidle, Ulrich H.   +4 more
core   +1 more source

Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment. [PDF]

PLoS ONE, 2018
Recent evidence indicates the presence of macrophage subpopulations that express the TCRαβ in chronic inflammatory diseases such as tuberculosis and atherosclerosis and in the tumor microenvironment.
Tina Fuchs, Martin Hahn, Lukas Ries, Sophie Giesler, Svenja Busch, Chunlin Wang, Jian Han, Torsten J Schulze, Kerstin Puellmann, Alexander W Beham, Wolfgang E Kaminski, Michael Neumaier   +11 more
doaj   +1 more source

The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]

, 2003
We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Santoro, Aniello, Nuttall, James, Ma, Julian K.-C., Vitale, A. (Alessandro), Hadlington, Jane L., Frigerio, Lorenzo, Denecke, J. (Jurgen)   +6 more
core   +1 more source

Immunoglobulin Heavy Chain Exclusion in the Shark

PLoS Biology, 2008
The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes. Adaptive responses to immune challenge are based on the expression of a single species of antigen receptor per cell; and in B cells, this is mediated in part by allelic exclusion at the Ig heavy (H) chain ...
Karolina Malecek, Victor Lee, Wendy Feng, Jing Li Huang, Martin F Flajnik, Yuko Ohta, Ellen Hsu   +6 more
openaire   +4 more sources