Results 21 to 30 of about 62,488 (307)
Immunoglobulin Heavy Chain Exclusion in the Shark
PLoS Biology, 2008 The adaptive immune system depends on specific antigen receptors, immunoglobulins (Ig) in B lymphocytes and T cell receptors (TCR) in T lymphocytes. Adaptive responses to immune challenge are based on the expression of a single species of antigen receptor per cell; and in B cells, this is mediated in part by allelic exclusion at the Ig heavy (H) chain ...
Karolina Malecek +6 more
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RAGs and Regulation of Autoantibodies [PDF]
, 2004 Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow.
Casellas, Rafael +4 more
core +1 more source
Monoclonal gammopathy of renal significance: Spectrum of diseases and approach to a case
Saudi Journal of Kidney Diseases and Transplantation, 2021 The occurrence of kidney diseases associated with a monoclonal gammopathy in the absence of symptomatic multiple myeloma is increasingly recognized. When the kidney is involved, the monoclonal etiology of these diseases results in clinical and laboratory
Rohit Tewari +5 more
doaj +1 more source
Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]
, 1991 We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Kaluzab, Brigitte +4 more
core +1 more source
Human Immunoglobulin Heavy Chain Genes
Journal of Biological Chemistry, 1989 genes in man, has lagged surprisingly behind similar information in the inbred mouse. The reasons for this are complicated but to some extent are related to the discovery of the myc oncogene. Thus, after genes encoding some of the constant region isotypes as well as the well defined “subgroups,”
J D, Capra, P W, Tucker
openaire +2 more sources
Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species
Frontiers in Immunology, 2022 Studies in humans and mice indicate the critical role of the surrogate light chain in the selection of the productive immunoglobulin repertoire during B cell development.
Marek Sinkora +5 more
doaj +1 more source
The antibody loci of the domestic goat (Capra hircus) [PDF]
, 2018 The domestic goat (Capra hircus) is an important ruminant species both as a source of antibody-based reagents for research and biomedical applications and as an economically important animal for agriculture, particularly for developing nations that ...
Bickhart, Derek M. +4 more
core +1 more source
Maturation of the Human Immunoglobulin Heavy Chain Repertoire With Age [PDF]
Frontiers in Immunology, 2020 B cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienced immunoglobulin heavy chain (IgH) repertoires.
Marie Ghraichy +18 more
openaire +5 more sources
The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]
, 2003 We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Hadlington, Jane L. +6 more
core +1 more source
mAbs, 2021 Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching +7 more
doaj +1 more source