Results 21 to 30 of about 35,294 (257)

Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species

Frontiers in Immunology, 2022
Studies in humans and mice indicate the critical role of the surrogate light chain in the selection of the productive immunoglobulin repertoire during B cell development.
Marek Sinkora, Katerina Stepanova, John E. Butler, Marek Sinkora, Simon Sinkora, Jana Sinkorova   +5 more
doaj   +1 more source

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

mAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton   +7 more
doaj   +1 more source

VH-RELATED IDIOTOPES DETECTED BY SITE-DIRECTED MUTAGENESIS [PDF]

, 1992
The function of the CD4 cell surface protein as coreceptor on T helper lymphocytes and as receptor for HIV makes this glycoprotein a prime target for an immune intervention with mAb.
Rieber, Ernst Peter, Weissenhorn, Winfried, Weiss, Elisabeth H., Cheng, Y. H., Riethmüller, Gert   +4 more
core   +1 more source

A comprehensive analysis of immunoglobulin heavy chain genes in the Bactrian camel (Camelus bactrianus) [PDF]

Frontiers of Agricultural Science and Engineering, 2015
Heavy chain only antibodies (HCAbs) represent a rare type of antibody that is devoid of light chains and the CH1 domain that have been reported in cartilaginous fish and camelids.
Zuoxiang LIANG,Tao WANG,Yi SUN,Wenlong YANG,Zhihong LIU,Jing FEI,Ying GUO,Qingwei MA,Qingjie PAN,Liming REN
doaj   +1 more source

Next generation Fc scaffold for multispecific antibodies

iScience, 2021
Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for ...
Bram Estes, Athena Sudom, Danyang Gong, Douglas A. Whittington, Vivian Li, Christopher Mohr, Danqing Li, Timothy P. Riley, Stone D.-H. Shi, Jun Zhang, Fernando Garces, Zhulun Wang   +11 more
doaj   +1 more source

Immune subtraction for improved resolution in serum protein immunofixation electrophoresis and antibody isotype determination in a patient with autoantibody

Practical Laboratory Medicine, 2021
Heavy chain isotypes of low level monoclonal immunoglobulins are sometimes obscured in serum immunofixation electrophoresis (SIFE) by a heavy background of polyclonal immunoglobulins.
Asad Ullah, Nivin Omar, Natasha M. Savage, Roni J. Bollag, Gurmukh Singh   +4 more
doaj   +1 more source

Expressions of immunoglobulin M and immunoglobulin D heavy chain in B-chronic lymphocytic leukemia and their correlation with CD38 expression

Iraqi Journal of Hematology, 2017
Background: B-chronic lymphocytic leukemia (CLL) is a monoclonal malignancy characterized by an accumulation of small mature-looking B lymphocytes in the blood, bone marrow, and other tissues.
Ghid Nahd Abdul Muhssen, Hind Shaker AL-Mamoori, Majid Hameed Ahmed   +2 more
doaj   +1 more source

Frequency of somatic hypermutation and heavy chain complementarity-determining region 3 (HCDR3) length of vaccine-elicited Env-reactive functional heavy- and light-chains identified using rhesus Ig sequence database.

, 2021
Analysis of percent somatic hypermutation frequency and HCDR3 lengths for Env-reactive heavy and light chains pairs (39 mAb pairs) from infant antigen-specific B cells based on human immunoglobulin (Ig) sequence database.
Kevin Wiehe (533027), Michael Hudgens (7055141), Mark A. Tomai (2682454), Papa K. Morgan-Asiedu (11890573), Shuk Hang Li (9635082), Riley J. Mangan (11890576), Erika Kunz (11890588), Kristina De Paris (9635085), Stella J. Berendam (6593099), Joshua A. Eudailey (11890582), M. Anthony Moody (10832847), Bonnie Phillips (11890585), Alan D. Curtis II (11890579), Kenneth Cronin (11890591), Sallie R. Permar (7310132), S. Munir Alam (164023), Holly Heimsath (7114262), Christopher B. Fox (231826), Hannah L. Itell (7310111), Genevieve G. Fouda (9565542), Kan Luo (3860764), Koen K. A. Van Rompay (8098412)   +21 more
core   +2 more sources

Immunoglobulin genes and diversity: what we have learned from domestic animals

Journal of Animal Science and Biotechnology, 2012
This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species—cattle, sheep, pigs, and horses—express a full range of Ig heavy chains (IgHs), including μ, δ, γ, ϵ, and α ...
Sun Yi, Liu Zhancai, Ren Liming, Wei Zhiguo, Wang Ping, Li Ning, Zhao Yaofeng   +6 more
doaj   +1 more source

Expansion of the preimmune antibody repertoire by junctional diversity in Bos taurus. [PDF]

PLoS ONE, 2014
Cattle have a limited range of immunoglobulin genes which are further diversified by antigen independent somatic hypermutation in fetuses. Junctional diversity generated during somatic recombination contributes to antibody diversity but its relative ...
Jenni Liljavirta, Mikael Niku, Tiina Pessa-Morikawa, Anna Ekman, Antti Iivanainen   +4 more
doaj   +1 more source