Results 31 to 40 of about 35,294 (257)

Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia [PDF]

, 2000
At diagnosis, clonal gene rearrangement probes {[}retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell receptor (TcR)-beta, myeloid lymphoid leukemia (MLL) or cytokine genes (GM-CSF, G-CSF, IL-3 ...
Mittermueller, J., Gerhartz, Helmut Heinrich, Schmetzer, Helga Maria, Braun, S., Wiesner, D., Duell, T.   +5 more
core   +1 more source

Evaluating the heavy/light chain immunoglobulin biomarker for early relapse detection in multiple myeloma: A comparative study with conventional methods

Clinical Immunology Communications
Objectives: The objective of this study is to evaluate the use of the immunoglobulin heavy/light chain biomarker in the early detection of biochemical relapse in patients with multiple myeloma under treatment.
Carla Azevedo, Ana Catarina Fonseca, João Pedro Barreto, Ana Marta Pires, Carina Faria, Andreia Pinto, Maria Emília Sousa, Carlos Palmeira, Cristina Prudêncio, Bruno Fernandes, Gabriela Martins, Ricardo Ferraz   +11 more
doaj   +1 more source

Structural repertoire of immunoglobulin λ light chains

, 2011
The immunoglobulin λ isotype is present in nearly all vertebrates and plays an important role in the human immune system. Despite its importance, few systematic studies have been performed to analyze the structural conformation of its variable regions ...
Anna Chailyan, Paolo Marcatili, CHAILYAN, ANNA, MARCATILI, PAOLO, Anna Tramontano, Davide Cirillo, TRAMONTANO, ANNA   +6 more
core   +2 more sources

Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion

Cell Death and Disease, 2023
Using multi-omics analyses including RNAseq, RT-PCR, RACE-PCR, and shotgun proteomic with enrichment strategies, we demonstrated that newborn rat astrocytes produce neural immunoglobulin constant and variable heavy chains as well as light chains. However,
Alice Capuz, Sylvain Osien, Mélodie Anne Karnoub, Soulaimane Aboulouard, Estelle Laurent, Etienne Coyaud, Antonella Raffo-Romero, Marie Duhamel, Amélie Bonnefond, Mehdi Derhourhi, Marco Trerotola, Ikram El Yazidi-Belkoura, David Devos, Monika Zilkova, Firas Kobeissy, Fabien Vanden Abeele, Isabelle Fournier, Dasa Cizkova, Franck Rodet, Michel Salzet   +19 more
doaj   +1 more source

Expression of μ and γ Immunoglobulin Heavy Chains in Different Cells of a Cloned Mouse Lymphoid Line

, 1981
A cloned cell line derived from mouse bone marrow and transformed by Abelson virus is shown to synthesize two different heavy chains, mu and gamma 2B, in vitro. This characteristic is stable because it persists upon subcloning.
Burrows, P., Beck, G., Wabl, M.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions

Frontiers in Immunology, 2016
Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the
Catherine L Townsend, Julie MJ Laffy, Yu-Chang Bryan Wu, Joselli Silva O'Hare, Victoria Martin, David Kipling, Franca Fraternali, Deborah K Dunn-Walters   +7 more
doaj   +1 more source

Identification of two rate-limiting steps in the degradation of partially folded immunoglobulin light chains

Frontiers in Cell and Developmental Biology, 2022
Antibody monomers are produced from two immunoglobulin heavy chains and two light chains that are folded and assembled in the endoplasmic reticulum This process is assisted and monitored by components of the endoplasmic reticulum quality control ...
Melissa J. Mann, Ashley R. Flory, Christina Oikonomou, Christina Oikonomou, Candace A. Hayes, Chris Melendez-Suchi, Linda M. Hendershot, Linda M. Hendershot   +7 more
doaj   +1 more source

Laser‐Induced Graphene from Waste Almond Shells

Advanced Functional Materials, EarlyView.
Almond shells, an abundant agricultural by‐product, are repurposed to create a fully bioderived almond shell/chitosan composite (ASC) degradable in soil. ASC is converted into laser‐induced graphene (LIG) by laser scribing and proposed as a substrate for transient electronics.
Yulia Steksova, Anna Chiara Bressi, Marina Galliani, Attilio Marino, Gianni Ciofani, Eduardo Machado‐Charry, Hilda Gomez Bernal, Alessandra Francini, Luca Sebastiani, Francesco Greco   +9 more
wiley   +1 more source

Detection of intracellular IgD using flow cytometry could be a novel and supplementary method to diagnose IgD multiple myeloma

BMC Cancer, 2018
Background We examined whether detecting the heavy chain of cytoplasmic immunoglobulin D (IgD) by flow cytometry could be used as a supplemental method to diagnose IgD multiple myeloma (MM).
Wei Wang, Chun-Xia Zhang, Zhen-Ling Li, Ming Gong, Yi-Gai Ma   +4 more
doaj   +1 more source