Immunoglobulin NGS enhance residual disease detection and prognosis in pediatric Ph+ acute lymphoblastic leukemia [PDF]
Frontiers in ImmunologyIn pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ B-ALL), the clinical value of highly sensitive minimal residual disease (MRD) detection by immunoglobulin next-generation sequencing (Ig-NGS), and its role for tracking ...
Lixian Chang +36 more
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Kappa free light chains in cerebrospinal fluid to detect inflammation - results from a multicentric prospective real-world study [PDF]
Frontiers in ImmunologyBackgroundFree light chain kappa (FLCκ) have emerged as a sensitive biomarker to detect intrathecal immunoglobulin synthesis. To evaluate the role of FLCκ in routine cerebrospinal fluid laboratory diagnostics we conducted a prospective nationwide real ...
Marie Süße +25 more
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Antigen binding characteristics of immunoglobulin free light chains: crosslinking by antigen is essential to induce allergic inflammation. [PDF]
PLoS ONE, 2012 Beside the production of complete immunoglobulins IgG, IgE, IgA, IgM and IgD, consisting of tetrameric heterodimers of immunoglobulin heavy and light chains, B cells also secrete immunoglobulin free light chains (Ig-fLC).
Marco Thio +5 more
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A novel liver-specific immunoglobulin heavy chain-like gene in a cartilaginous fish
Fish and Shellfish Immunology Reports, 2023 We identified a novel immunoglobulin (Ig) heavy chain-like gene (tsIgH) expressed in the liver of the banded houndshark Triakis scyllium by preliminary transcriptomic analysis.
Hidehiro Kondo +7 more
doaj +1 more source
Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment. [PDF]
PLoS ONE, 2018 Recent evidence indicates the presence of macrophage subpopulations that express the TCRαβ in chronic inflammatory diseases such as tuberculosis and atherosclerosis and in the tumor microenvironment.
Tina Fuchs +11 more
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Immunoglobulin Expression in Cancer Cells and Its Critical Roles in Tumorigenesis
Frontiers in Immunology, 2021 Traditionally, immunoglobulin (Ig) was believed to be produced by only B-lineage cells. However, increasing evidence has revealed a high level of Ig expression in cancer cells, and this Ig is named cancer-derived Ig.
Ming Cui +5 more
doaj +1 more source
PLoS ONE, 2023 BackgroundDespite the increasing number of cases of secondary antibody deficiency (SAD) and immunoglobulin (Ig) utilization, there is a paucity of data in the literature on clinical and patient-reported outcomes in this population.ObjectiveTo describe ...
Armin Abadeh +5 more
doaj +1 more source
Qualitative Research in Medicine & Healthcare, 2021 This paper describes the burden of receiving immunoglobulin (Ig) treatment from the perspective of patients diagnosed with a Primary Immunodeficiency (PID).
Georgina Jones +12 more
doaj +1 more source
Impact of rituximab on immunoglobulin concentrations and B cell numbers after cyclophosphamide treatment in patients with ANCA-associated vasculitides. [PDF]
PLoS ONE, 2012 OBJECTIVE: To assess the impact of immunosuppressive therapy with cyclophosphamide (CYC) and rituximab (RTX) on serum immunoglobulin (Ig) concentrations and B lymphocyte counts in patients with ANCA-associated vasculitides (AAVs).
Nils Venhoff +8 more
doaj +1 more source
Life Science Alliance, 2022 Using polyclonal IgM-enriched immunoglobulin (IgM-IG) as adjuvant therapy to colistin appears useful in the treatment of pneumonia caused by multidrug-resistant strains of P. aeruginosa .
Tania Cebrero-Cangueiro +7 more
doaj +1 more source