Results 211 to 220 of about 14,209 (224)
Some of the next articles are maybe not open access.
Immunoglobulin Light Chain and Systemic Light-Chain Amyloidosis
2007Light-chain amyloidosis (AL) is characterized by the clonal expansion of plasma B cells that secrete large amounts of monoclonal immunoglobulin light chains. The free light chains circulate in serum and form amyloid fibrils on vital organs such as the kidney, heart, and liver causing organ failure and eventually death.
Richard W. McLaughlin +5 more
openaire +2 more sources
Stem cell transplantation for immunoglobulin light chain amyloidosis
Current Problems in Cancer, 2017Systemic chemotherapy aimed at eradicating transformed plasma cells is the mainstay of treatment for immunoglobulin light chain amyloidosis (AL). Autologous stem cell transplantation (SCT) is a highly effective treatment for AL and can lead to long term survival in excess of 10 years in patients who achieve complete remission.
Taimur Sher, Morie A. Gertz
openaire +3 more sources
Pathology International, 2006
To detect immunoglobulin (Ig) light chain amyloidosis (AL amyloidosis) in formalin‐fixed, paraffin‐embedded tissue sections by immunohistochemistry, polyclonal antibodies were generated against synthetic peptides corresponding to amino acids 1–19 of the Ig λ light chain V λ VI subgroup (anti‐V λ VI (1–19)) and the Ig κ light chain Vκ I subgroup (anti ...
Dan Cui +4 more
openaire +3 more sources
To detect immunoglobulin (Ig) light chain amyloidosis (AL amyloidosis) in formalin‐fixed, paraffin‐embedded tissue sections by immunohistochemistry, polyclonal antibodies were generated against synthetic peptides corresponding to amino acids 1–19 of the Ig λ light chain V λ VI subgroup (anti‐V λ VI (1–19)) and the Ig κ light chain Vκ I subgroup (anti ...
Dan Cui +4 more
openaire +3 more sources
The Challenge of Systemic Immunoglobulin Light-Chain Amyloidosis (AL)
2012The cardiac involvement and associated mortality that occur in systemic AL amyloidosis remain among the most challenging aspects of the systemic amyloid-related diseases. Monoclonal immunoglobulin light chains produced by a clone of plasma cells are usually the cause of symptoms and organ dysfunction via both poorly understood toxic effects of ...
PALLADINI, GIOVANNI, Comenzo, Raymond L.
openaire +4 more sources
Antibody‐based immunotherapy for treatment of immunoglobulin light‐chain amyloidosis
British Journal of Haematology, 2020SummaryImmunoglobulin light‐chain (AL) amyloidosis is a clonal plasma cell disorder characterised by production and deposition of misfolded monoclonal light chains in vital organs with potential to cause irreversible organ damage. The treatment of AL amyloidosis has evolved along the lines of multiple myeloma (MM) owing to clonal plasma cells being at ...
Ricardo D. Parrondo +2 more
openaire +3 more sources
Diagnosis and Therapy of Immunoglobulin Light Chain Amyloidosis (AL Amyloidosis)
2012Amyloidosis is a group of disorders that have in common the deposition of protein fibrils composed of protofibrils that have a crystallographic β(beta)-pleated sheet structure. Disease results from these proteinaceous deposits in one or more organ systems [1].
Morie A. Gertz, Robert A. Kyle
openaire +2 more sources
Flow cytometry in immunoglobulin light chain amyloidosis: Short review
Leukemia Research, 2015Flow cytometry (FCM) has found its application in clinical diagnosis and evaluation of monoclonal gammopathies (MG). Although, research has been mainly focused on multiple myeloma (MM), nowadays FCM becomes to be potential tool in the field of AL amyloidosis.
Elena Kryukova +6 more
openaire +3 more sources
Amyloidosis Related to a λ IV Immunoglobulin Light Chain Protein
Scandinavian Journal of Immunology, 1989Amyloid subunit proteins related to the λ IV subgroup of immunoglobulin light chains have not been previously reported. We have determined the amino acid sequence of an AL amyloid protein BAK and shown that it has the structure typical of λ IV light chain proteins.
Merrill D. Benson +3 more
openaire +3 more sources
Immunoglobulin Light Chain Amyloidosis
2018Taxiarchis Kourelis, Morie A. Gertz
openaire +1 more source
Glycosylation of Immunoglobulin Light Chains is Associated with Amyloidosis
Clinical Lymphoma Myeloma and Leukemia, 2017David R. Barnidge +6 more
openaire +2 more sources