Results 181 to 190 of about 394,026 (356)

Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy

Advanced Science, EarlyView.
Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang, Shu‐Ying Li, Fang‐Fei Li, Qin‐Yan Shi, Cheng‐Yong Tan, Xiao‐Jing Wang, Mi Li, Yun‐Bao Liu, Jing Jin, Yong Li, Shi‐Shan Yu   +10 more
wiley   +1 more source

Alterations of the gut microbiota in patients with immunoglobulin light chain amyloidosis. [PDF]

Front Immunol, 2022
Yan J, Zhao J, Ning X, Qin Y, Xing Y, Wang Y, Jia Q, Huang B, Ma R, Lei C, Zhou M, Yu Z, Zhang Y, Guo WF, Sun S.   +14 more
europepmc   +1 more source

Primary systemic amyloidosis: a case report [PDF]

, 2017
Primary amyloidosis is a group of monoclonal plasma cell disorders, characterized by extracellular deposition of immunoglobulin light chain fibrils in multiple organs leading to progressive multiorgan dysfunction.
CA, Jayashankar, KV, Santosh, Mathew, Praveen, Nandennavar, Manjunath, Perugu, Pavan Kumar, Somasekar, D. S.   +5 more
core   +1 more source

UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling

Advanced Science, EarlyView.
Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan, Xueman Chen, Huai Yu, Jianzhao Ruan, Jingliang Kang, Xiaoyu Nie, Yumei Cao, Su'an Tang, Changhai Ding   +8 more
wiley   +1 more source

Prognostic value of right ventricular global longitudinal strain in patients with immunoglobulin light-chain cardiac amyloidosis. [PDF]

Eur Heart J Open, 2023
Usuku H, Yamamoto E, Sueta D, Noguchi M, Fujisaki T, Egashira K, Oike F, Fujisue K, Hanatani S, Arima Y, Takashio S, Kawano Y, Oda S, Kawano H, Matsushita K, Matsushita K, Ueda M, Matsui H, Matsuoka M, Tsujita K.   +19 more
europepmc   +1 more source

Amino acid sequence of the NH2-terminal extra piece segments of the precursors of mouse immunoglobulin lambda1-type and kappa-type light chains. [PDF]

, 1977
Yigal Burstein, Israël Schechter
openalex   +1 more source

Nanomedicine Penetrating Blood‐Pancreas Barrier for Effective Treatment of Acute Pancreatitis

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study introduces tungsten‐based heteropolyacid nano‐antioxidants (mTWNDs), which are co‐modified with tannic acid (TA) and melanin (A). It is able to cross the damaged blood‐pancreas barrier (BPB) to reach the mitochondria of the pancreatic acinar cells (PACs) and specifically scavenge reactive oxygen species (ROS) to treat acute pancreatitis (AP)
Dan Wang, Shuya Wang, Jinjin Liu, Xiaojing Shi, Tingli Xiong, Ruishi Li, Wei Wei, Liandong Ji, Qiong Huang, Xuejun Gong, Kelong Ai   +10 more
wiley   +1 more source

The correlation of left atrial dysfunction and amyloid load in patients with immunoglobulin light-chain cardiac amyloidosis: a 3T cardiac magnetic resonance study. [PDF]

Br J Radiol, 2023
Lu J, Yang Z, Tang D, Luo Y, Xiang C, Zhou X, Huang L, Xia L.   +7 more
europepmc   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, Volume 12, Issue 16, April 24, 2025.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source

Vasovagal Syncope and Pulseless Electrical Activity Cardiac Arrest in Patients With Immunoglobulin Light Chain Cardiac Amyloidosis: A Case Series. [PDF]

Cureus, 2023
Sperry BW, Harhash AA, Cossor F, Raza S.
europepmc   +1 more source