Individual B cells transcribe multiple rearranged immunoglobulin light chains in teleost fish [PDF]
iScience, 2021 Summary: B cells express a unique antibody protein which comprises two pairs of immunoglobulin (Ig) heavy (H) and light (L) chains. In addition to an invariable constant (C) region, IgH and IgL chains encompass a variable (V) region mediating antigen ...
Pedro Perdiguero +3 more
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Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains [PDF]
BMC Biology, 2023 Background In a range of human disorders such as multiple myeloma (MM), immunoglobulin light chains (IgLCs) can be produced at very high concentrations. This can lead to pathological aggregation and deposition of IgLCs in different tissues, which in turn
Rebecca Sternke-Hoffmann +19 more
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Heterohybridomas producing human immunoglobulin light chains using CD138-selected bone marrow cells [PDF]
Biochemistry and Biophysics ReportsBackground: Light chain research is hampered by lack of mammalian cell lines producing human light chains (FLC). Therefore, we used heterohybridoma (HH) technology to produce clones making FLC thereby providing tools to study light chain behavior ...
P. Zhou +8 more
doaj +2 more sources
Truncation of the constant domain drives amyloid formation by immunoglobulin light chains [PDF]
Journal of Biological ChemistryAL amyloidosis is a life-threatening disease caused by deposition of immunoglobulin light chains. Whilst the mechanisms underlying light chains amyloidogenesis in vivo remain unclear, several studies have highlighted the role that tissue environment and ...
Mónica Concardi +2 more
exaly +5 more sources
Gut mycobiome dysbiosis contributes to the development of hypertension and its response to immunoglobulin light chains [PDF]
Frontiers in Immunology, 2022 Anxing Ge, Yeqing Zou, Qianying Wang
exaly +2 more sources
Alteration of the Gut Microbiome in Chronic Kidney Disease Patients and Its Association With Serum Free Immunoglobulin Light Chains [PDF]
Frontiers in Immunology, 2021 Tingting Xiao, Peng Jiang
exaly +2 more sources
Chromogenic in situ hybridization for the detection of lambda and kappa immunoglobulin light chains as a potential auxiliary diagnostic technique in canine plasmacytomas [PDF]
Journal of Veterinary Diagnostic Investigation, 2020 Marco Tecilla +2 more
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Different roles of urinary light chains and serum light chains as potential biomarkers for monitoring disease activity in systemic lupus erythematosus [PDF]
PeerJ, 2022 Objective The assessment system for monitoring systemic lupus erythematosus (SLE) disease activity is complex and lacks reliable laboratory indicators. It is necessary to find rapid and noninvasive biomarkers.
Jun Jiang, Jin Zhao, Dan Liu, Man Zhang
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Systemic immunoglobulin light chain amyloidosis [PDF]
Nature Reviews Disease Primers, 2018 Systemic immunoglobulin light chain amyloidosis is a protein misfolding disease caused by the conversion of immunoglobulin light chains from their soluble functional states into highly organized amyloid fibrillar aggregates that lead to organ dysfunction.
Merlini G. +6 more
openaire +6 more sources
Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]
PeerJ, 2023 The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova +4 more
doaj +2 more sources