Individual B cells transcribe multiple rearranged immunoglobulin light chains in teleost fish [PDF]
iScience, 2021 Summary: B cells express a unique antibody protein which comprises two pairs of immunoglobulin (Ig) heavy (H) and light (L) chains. In addition to an invariable constant (C) region, IgH and IgL chains encompass a variable (V) region mediating antigen ...
Pedro Perdiguero +3 more
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Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains [PDF]
BMC Biology, 2023 Background In a range of human disorders such as multiple myeloma (MM), immunoglobulin light chains (IgLCs) can be produced at very high concentrations. This can lead to pathological aggregation and deposition of IgLCs in different tissues, which in turn
Rebecca Sternke-Hoffmann +19 more
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Immunoglobulin light chains in uremia [PDF]
Kidney International, 2003 Immunoglobulin light chains (IgLCs) are produced by B cells, slightly in excess of immunoglobulin heavy chains, and therefore are present in the serum of healthy adults in free form at low concentrations. Both the kappa and lambda form of these polyclonal IgLCs are mainly metabolized by the kidney and appear under normal conditions only in small ...
Gerald Cohen, Cohen, Gerald
openaire +3 more sources
Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis. [PDF]
PLoS ONE, 2009 The amyloidoses are protein misfolding diseases characterized by the deposition of amyloid that leads to cell death and tissue degeneration. In immunoglobulin light chain amyloidosis (AL), each patient has a unique monoclonal immunoglobulin light chain ...
Tanya L Poshusta +5 more
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Antibody Light Chains: Key to Increased Monoclonal Antibody Yields in Expi293 Cells?
Antibodies, 2022 When constructing isogenic recombinant IgM–IgG pairs, we discovered that μ heavy chains strongly prefer partnering with λ light chains for optimal IgM expression in transiently cotransfected Expi293 cells.
Siqi Gong +4 more
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The CDR1 and other regions of immunoglobulin light chains are hot spots for amyloid aggregation [PDF]
Sci Rep, 2019 Immunoglobulin light chain-derived (AL) amyloidosis is a debilitating disease without known cure. Almost nothing is known about the structural factors driving the amyloidogenesis of the light chains.
Luis del Pozo-Yauner (16288025) +13 more
core +3 more sources
Urine and Free Immunoglobulin Light Chains as Analytes for Serodiagnosis of Hantavirus Infection [PDF]
Viruses, 2019 Rapid point-of-care testing is a megatrend in infectious disease diagnosis. We have introduced a homogeneous immunoassay concept, which is based on the simultaneous binding of antigen and protein L to a given immunoglobulin molecule.
Satu Hepojoki +9 more
doaj +2 more sources
Медицинская иммунология, 2015 Increased intrathecal synthesis and oligoclonal banding of immunoglobulins (Ig) in cerebrospinal fluid (CSF) are major immunological findings in multiple sclerosis.
V. D. Nazarov +5 more
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Different roles of urinary light chains and serum light chains as potential biomarkers for monitoring disease activity in systemic lupus erythematosus [PDF]
PeerJ, 2022 Objective The assessment system for monitoring systemic lupus erythematosus (SLE) disease activity is complex and lacks reliable laboratory indicators. It is necessary to find rapid and noninvasive biomarkers.
Jun Jiang, Jin Zhao, Dan Liu, Man Zhang
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Free light chains of immunoglobulin as a prognostic factor for some plasmaproliferative diseases [PDF]
Journal of Medical Biochemistry, 2011 Quantitation of monoclonal immuno globulins and their fragments is used for monitoring the plasmaproliferative disease course and the effect of therapy.
Mijušković Zoran +5 more
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