Results 31 to 40 of about 3,969,240 (284)

Biomarkers in Immunoglobulin Light Chain Amyloidosis

Klinicka Onkologie, 2017
Immunoglobulin light chain amyloidosis (AL amyloidosis - ALA) is a monoclonal gammopathy characterized by presence of aberrant plasma cells producing amyloidogenic immunoglobulin light chains. This leads to formation of amyloid fibrils in various organs and tissues, mainly in heart and kidney, and causes their dysfunction.
Kufova, Z., Sevcikova, T., Growkova, K., Vojta, P., Filipova, J., Adam, Z., Pour, L., Penka, M., Rysava, R., Nemec, P., Brozova, L., Vychytilova, P., Jurczyszyn, Artur, Grosicki, S., Barchnicka, A., Hajduch, M., Simicek, M., Hajek, R.   +17 more
openaire   +4 more sources

Pattern of serum immunoglobulins and free light chain levels among patients diagnosed with multiple myeloma in Southeast Nigeria

International Journal of Medicine and Health Development, 2023
Background: Abnormal plasma cells in multiple myeloma produce excessive amounts of immunoglobulins and free light chains, of which certain patterns predict patient survival.
Ifeyinwa D Nnakenyi, Anazoeze J Madu, Ifeoma C Ajuba, Sunday Ocheni, Gladys U Ilechukwu, Nnenna Ogbodo, Oji A Nnachi   +6 more
doaj   +1 more source

Elevated serum polyclonal immunoglobulin free light chains in patients with severe asthma

Frontiers in Pharmacology, 2023
Background: Inflammation plays a pivotal role in the pathophysiology of asthma. Free light chains (FLC) can cause inflammation by mast cell antigen-activation. Serum immunoglobulin (Ig) FLC κ, but not λ, were shown elevated in adult males with asthma. We
Umberto Basile, Umberto Basile, Giuseppe Santini, Giuseppe Santini, Cecilia Napodano, Giuseppe Macis, Krizia Pocino, Francesca Gulli, Mario Malerba, Andrew Bush, Ian M. Adcock, Paolo Montuschi, Paolo Montuschi   +12 more
doaj   +1 more source

Immunoglobulin light chain amyloidosis [PDF]

memo - Magazine of European Medical Oncology, 2021
SummaryImmunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed life-threatening systemic disease, primarily caused by insoluble depositions of misfolded monoclonal light chains. The monoclonal light chain paraprotein originates from a small clonal B‑cell or a clonal plasma cell population.
Hermine Agis, Maria T. Krauth
openaire   +1 more source

Significant differences in physicochemical properties of human immunoglobulin kappa and lambda CDR3 regions

Frontiers in Immunology, 2016
Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the
Catherine L Townsend, Julie MJ Laffy, Yu-Chang Bryan Wu, Joselli Silva O'Hare, Victoria Martin, David Kipling, Franca Fraternali, Deborah K Dunn-Walters   +7 more
doaj   +1 more source

Hsc70-induced changes in clathrin-auxilin cage structure suggest a role for clathrin light chains in cage disassembly [PDF]

, 2013
The molecular chaperone, Hsc70, together with its co-factor, auxilin, facilitates the ATP-dependent removal of clathrin during clathrin-mediated endocytosis in cells.
Brodsky, Frances M., Vallis, Yvonne, Stoilova‐McPhie, Svetla, Ranson, Neil, Smith, Corinne J., Harvey-Smith, Phillip, Roseman, Alan; id_orcid, Young, Anna, Stoilova-McPhie, Svetla, Kent, Helen, Roseman, Alan, Pearse, Barbara M.F., Pearse, Barbara M. F., Harvey‐Smith, Phillip, Rothnie, Alice   +14 more
core   +1 more source

Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis? [PDF]

, 2017
Objectives: Light chains κ and λ are immunoglobulin constituents but also circulate independently in blood as free light chains. We investigated whether a concomitant abnormality in free light chain and immunoglobulin levels could identify a high risk of
Singer, M, Mervyn Singer, Manu Shankar-Hari, Singer, Mervyn, Spencer, Jo, Shankar-Hari, M, Spencer, J, Shankar-Hari, Manu, Jo Spencer   +8 more
core   +2 more sources

Bence-Jones Proteins and Light Chains of Immunoglobulins [PDF]

Journal of Biological Chemistry, 1969
Three distinct classes of κ light polypeptide chains have been detected immunochemically by an antiserum (R185) prepared against a κ Bence Jones protein with a glutamyl amino terminal residue. This antiserum had specificity for κ light chains with glutamyl amino terminal residues and differentiated κ-chains with aspartyl amino terminal residues into ...
A, Solomon, C L, McLaughlin
openaire   +2 more sources

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain

eLife, 2015
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Boris Brumshtein, Shannon R Esswein, Lukasz Salwinski, Martin L Phillips, Alan T Ly, Duilio Cascio, Michael R Sawaya, David S Eisenberg   +7 more
doaj   +1 more source

A Hands-on Activity for V(D)J Recombination in an Undergraduate Immunology Class

Journal of Microbiology & Biology Education, 2023
This learning activity teaches the difficult concept of V(D)J recombination as it occurs in B cells. Following the traditional lecture, this hands-on activity uses pipe cleaners of various colors representing variable, joining, and diversity gene ...
Kelly N. Hallstrom, Gwendowlyn S. Knapp
doaj   +1 more source