Results 31 to 40 of about 50,405 (295)
Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis? [PDF]
, 2017 Objectives: Light chains κ and λ are immunoglobulin constituents but also circulate independently in blood as free light chains. We investigated whether a concomitant abnormality in free light chain and immunoglobulin levels could identify a high risk of
Singer, M +8 more
core +1 more source
Structural repertoire of immunoglobulin λ light chains
, 2011 The immunoglobulin λ isotype is present in nearly all vertebrates and plays an important role in the human immune system. Despite its importance, few systematic studies have been performed to analyze the structural conformation of its variable regions ...
Anna Chailyan +6 more
core +2 more sources
Frontiers in Immunology, 2016 Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the
Catherine L Townsend +7 more
doaj +1 more source
A Hands-on Activity for V(D)J Recombination in an Undergraduate Immunology Class
Journal of Microbiology & Biology Education, 2023 This learning activity teaches the difficult concept of V(D)J recombination as it occurs in B cells. Following the traditional lecture, this hands-on activity uses pipe cleaners of various colors representing variable, joining, and diversity gene ...
Kelly N. Hallstrom, Gwendowlyn S. Knapp
doaj +1 more source
, 2022 Data and analysis scripts for the paper: Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains. The context of the data files is described in the paper and the material deposited here is intended for ...
Rebecca Sternke-Hoffmann (14195194) +19 more
core +1 more source
BioMedInformatics, 2023 Human immunoglobulin allotypes are allelic antigenic determinants (or “markers”) determined serologically, classically by hemagglutination inhibition, on the human immunoglobulin (IG) or antibody heavy and light chains. The allotypes have been identified
Marie-Paule Lefranc, Gérard Lefranc
doaj +1 more source
Bence-Jones Proteins and Light Chains of Immunoglobulins [PDF]
Journal of Biological Chemistry, 1969 Three distinct classes of κ light polypeptide chains have been detected immunochemically by an antiserum (R185) prepared against a κ Bence Jones protein with a glutamyl amino terminal residue. This antiserum had specificity for κ light chains with glutamyl amino terminal residues and differentiated κ-chains with aspartyl amino terminal residues into ...
Alan Solomon, Carla L McLaughlin
openaire +1 more source
Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species
Frontiers in Immunology, 2022 Studies in humans and mice indicate the critical role of the surrogate light chain in the selection of the productive immunoglobulin repertoire during B cell development.
Marek Sinkora +5 more
doaj +1 more source
Recommendations for use of free light chain assay in monoclonal gammopathies [PDF]
Journal of Medical Biochemistry, 2010 The serum immunoglobulin free light chain assay measures levels of free k and l immunoglobulin light chains. There are three major indications for the free light chain assay in the evaluation and management of multiple myeloma and related plasma cell ...
Radović Vesna V.
doaj
eLife, 2015 Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Boris Brumshtein +7 more
doaj +1 more source