Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions [PDF]
Frontiers in Immunology, 2016 Antibody variable regions are composed of a heavy and a light chain and in humans there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with the
David Kipling +2 more
exaly +6 more sources
Frontiers in Immunology, 2022 ObjectivesHuman gut microbiome has gained great attention for its proposed roles in the development of hypertension. The fungal microbiome in the human gut (i.e.
Anxing Ge, Yeqing Zou, Qianying Wang
exaly +3 more sources
Biomedicines, 2022 The gold standard for detecting intrathecal immunoglobulin synthesis is the determination of the oligoclonal band (OCB) in the cerebrospinal fluid (CSF) using isoelectric focusing (IEF).
Thomas Seifert-Held +2 more
exaly +3 more sources
Light chain deposition disease masquerading as hypophosphatemic osteomalacia: a case report [PDF]
Frontiers in MedicineLight chain deposition disease (LCDD) is characterized by the deposition of monotypic immunoglobulin light chains in multiple organs. The kidneys are usually affected in cases of LCCD, and they typically present with mesangial nodule formation, extensive
Jiannan Chen +6 more
doaj +2 more sources
Kappa free light chains in cerebrospinal fluid to detect inflammation - results from a multicentric prospective real-world study [PDF]
Frontiers in ImmunologyBackgroundFree light chain kappa (FLCκ) have emerged as a sensitive biomarker to detect intrathecal immunoglobulin synthesis. To evaluate the role of FLCκ in routine cerebrospinal fluid laboratory diagnostics we conducted a prospective nationwide real ...
Marie Süße +25 more
doaj +2 more sources
Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains [PDF]
Nucleic Acids Research, 1980 In many myelomas more than one kappa gene is rearranged (2-5). We are reporting here the results of studies undertaken to determine whether all the rearranged genes are expressed. It was found that in the myeloma NS-1 three different rearranged kappa genes exist.
Ursula Storb, U Storb
exaly +3 more sources
Evaluation of vaccine-induced antibody responses against SARS-CoV-2 in multiple myeloma patients from the northeastern region of Mexico [PDF]
Hematology, Transfusion and Cell TherapyObjective: To evaluate immunoglobulin G antibody responses against Severe Acute Respiratory Syndrome Coronavirus 2 in multiple myeloma patients in the northeastern region of Mexico following different COVID-19 vaccination regimens.
Rosario Salazar-Riojas +6 more
doaj +2 more sources
A rare case of systemic AL-amyloidosis under the mask of myocardial infarction in the absence of myocardial hypertrophy: case report [PDF]
КардиоСоматика, 2022 Systemic amyloidosis is a group of diseases associated with extracellular deposition of fibrillar proteins, resulting in the loss of normal organ structure and function. AL-amyloidosis occurs when amyloid is deposited, consisting of full-length lambda or
Svetlana A. Boldueva +4 more
doaj +1 more source
Kidney Medicine, 2023 The kidney pathology of monoclonal gammopathy of renal significance varies greatly. In this report, we present a woman in her 20s with nephrotic syndrome and monoclonal immunoglobulin G kappa (serum and urine) without diabetes.
Ai Katsuma +6 more
doaj +1 more source
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]
PLoS ONE, 2014 Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita +7 more
doaj +1 more source