Results 1 to 10 of about 74,618 (225)
Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains [PDF]
Nucleic Acids Research, 1980 In many myelomas more than one kappa gene is rearranged (2-5). We are reporting here the results of studies undertaken to determine whether all the rearranged genes are expressed. It was found that in the myeloma NS-1 three different rearranged kappa genes exist.
Ursula Storb, B Arp, Richard Wilson
exaly +4 more sources
Roles of the disulfide bond between the variable and the constant domains of rabbit immunoglobulin kappa chains in thermal stability and affinity [PDF]
Protein Engineering, Design and Selection, 2018 Rabbit antibodies show unique structural characteristics in that kappa chains have an inter-domain disulfide bond between the variable and constant domains.
Raiji Kawade +5 more
semanticscholar +3 more sources
Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains.
Journal of Experimental Medicine, 1984 Using a cloned cDNA of a mouse immunoglobulin kappa light chain synthesized in a myeloma MOPC321 (V kappa-21 subgroup C) as a probe we could detect 13 germ line V kappa gene segments. 11 of these were isolated. Using a set of overlapping cloned segments,
André Traunecker +2 more
exaly +2 more sources
Acta Neurologica Scandinavica, 2009 Background – So far, an inflammation of the central nervous system (CNS) is diagnosed by immunoglobulin measurement in cerebrospinal fluid (CSF) and serum as well as by determination of the oligoclonal bands. With the free kappa and lambda light chains,
F Birklein
exaly +2 more sources
Multiple Sclerosis, 2022 Background: Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. Objective: To perform a systematic review and meta-
H. Hegen +13 more
semanticscholar +1 more source
Multiple Sclerosis, 2022 Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease,
H. Hegen +11 more
semanticscholar +1 more source
Immunoglobulin kappa chain allotypes (KM) in onchocerciasis. [PDF]
Journal of Clinical Investigation, 1995 GM and KM allotypes, powerful tools for genetic characterization of human populations, have been shown to play an important role in genetic predisposition to some infectious diseases. Two diverse racial groups--Afro-Ecuadorians and Amerindians--living in a single restricted geographical area of Ecuador, appear to have different risk factors for ...
J P, Pandey +5 more
openaire +2 more sources
For Breast Cancer Prognosis, Immunoglobulin Kappa Chain Surfaces to the Top [PDF]
Clinical Cancer Research, 2012 Abstract The stromal immunoglobulin kappa chain (IGKC) has been validated as an immunologic biomarker of prognosis and response to therapy in human breast cancer and other cancers. This validation emphasizes the key role of humoral immunity in control of cancer progression and has major implications for determining prognosis of ...
Theresa L, Whiteside, Soldano, Ferrone
openaire +2 more sources
Evolution of immunoglobulin kappa chain variable region genes in vertebrates [PDF]
Molecular Biology and Evolution, 1998 The major source of immunoglobulin diversity is variation in DNA sequence among multiple copies of variable region (V) genes of the heavy- and light-chain multigene families. In order to clarify the evolutionary pattern of the multigene family of immunoglobulin light kappa chain V region (V kappa) genes, phylogenetic analyses of V kappa genes from ...
T, Sitnikova, M, Nei
openaire +2 more sources
Intrathecal kappa free light chains as markers for multiple sclerosis
Scientific Reports, 2020 Cerebrospinal fluid (CSF) kappa free light chain (KFLC) index has been described as a reliable marker of intrathecal IgG synthesis to diagnose multiple sclerosis (MS).
D. Vecchio +8 more
semanticscholar +1 more source