Kappa free light chains in cerebrospinal fluid to detect inflammation - results from a multicentric prospective real-world study [PDF]
Frontiers in ImmunologyBackgroundFree light chain kappa (FLCκ) have emerged as a sensitive biomarker to detect intrathecal immunoglobulin synthesis. To evaluate the role of FLCκ in routine cerebrospinal fluid laboratory diagnostics we conducted a prospective nationwide real ...
Marie Süße +25 more
doaj +2 more sources
Biomedicines, 2022 The gold standard for detecting intrathecal immunoglobulin synthesis is the determination of the oligoclonal band (OCB) in the cerebrospinal fluid (CSF) using isoelectric focusing (IEF).
Bastian Weiss +8 more
doaj +3 more sources
Evaluation of vaccine-induced antibody responses against SARS-CoV-2 in multiple myeloma patients from the northeastern region of Mexico [PDF]
Hematology, Transfusion and Cell TherapyObjective: To evaluate immunoglobulin G antibody responses against Severe Acute Respiratory Syndrome Coronavirus 2 in multiple myeloma patients in the northeastern region of Mexico following different COVID-19 vaccination regimens.
Rosario Salazar-Riojas +6 more
doaj +2 more sources
Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains [PDF]
Nucleic Acids Research, 1980 In many myelomas more than one kappa gene is rearranged (2-5). We are reporting here the results of studies undertaken to determine whether all the rearranged genes are expressed. It was found that in the myeloma NS-1 three different rearranged kappa genes exist.
U, Storb, B, Arp, R, Wilson
exaly +3 more sources
A rare case of systemic AL-amyloidosis under the mask of myocardial infarction in the absence of myocardial hypertrophy: case report [PDF]
КардиоСоматика, 2022 Systemic amyloidosis is a group of diseases associated with extracellular deposition of fibrillar proteins, resulting in the loss of normal organ structure and function. AL-amyloidosis occurs when amyloid is deposited, consisting of full-length lambda or
Svetlana A. Boldueva +4 more
doaj +1 more source
Estimated glomerular filtration rate is a poor predictor of the concentration of middle molecular weight uremic solutes in chronic kidney disease [PDF]
, 2012 Background: Uremic solute concentration increases as Glomerular Filtration Rate (GFR) declines. Weak associations were demonstrated between estimated GFR (eGFR) and the concentrations of several small water-soluble and protein-bound uremic solutes ...
Barreto, Daniela V +9 more
core +14 more sources
Kidney Medicine, 2023 The kidney pathology of monoclonal gammopathy of renal significance varies greatly. In this report, we present a woman in her 20s with nephrotic syndrome and monoclonal immunoglobulin G kappa (serum and urine) without diabetes.
Ai Katsuma +6 more
doaj +1 more source
Frontiers in Immunology, 2022 ObjectivesHuman gut microbiome has gained great attention for its proposed roles in the development of hypertension. The fungal microbiome in the human gut (i.e.
Yeqing Zou +5 more
doaj +1 more source
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]
PLoS ONE, 2014 Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita +7 more
doaj +1 more source
Immunoglobulin kappa chain allotypes (KM) in onchocerciasis. [PDF]
Journal of Clinical Investigation, 1995 GM and KM allotypes, powerful tools for genetic characterization of human populations, have been shown to play an important role in genetic predisposition to some infectious diseases. Two diverse racial groups--Afro-Ecuadorians and Amerindians--living in a single restricted geographical area of Ecuador, appear to have different risk factors for ...
J P, Pandey +5 more
openaire +2 more sources