Results 31 to 40 of about 29,558 (298)

Localization, analysis and evolution of transposed human immunoglobulin VK genes [PDF]

, 1988
The localization of Vκ gene regions to chromosome 2, on which the κ locus is located, and to other chromosomes is described. The Vκ genes that have been transposed to other chromosomes are called orphons.
Bauer, Bernhard Straubinger, Church, Erika Lötscher, Falkner, Franz-Josef Zimmer, Hans G. Zachau, Holst, Honjo, Jaenichen, Kabat, Karl-Heinz Grzeschik, Klobeck, Lorenz, Lötscher, Lötscher, Lötscher, Malcolm, McBride, Pech, Pech, Pohlenz, Pohlenz, Rita Jaenichen, Straubinger, Straubinger, Thomas Klopstock, Tonegawa   +27 more
core   +1 more source

DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF INTRATHECAL SYNTHESIS OF IMMUNOGLOBULIN FREE LIGHT CHAINS IN MULTIPLE SCLEROSIS

Медицинская иммунология, 2015
Increased intrathecal synthesis and oligoclonal banding of immunoglobulins (Ig) in cerebrospinal fluid (CSF) are major immunological findings in multiple sclerosis.
V. D. Nazarov, S. V. Lapin, E. A. Surkova, E. P. Evdoshenko, G. S. Makshakov, Areg A. Totolian   +5 more
doaj   +1 more source

Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene. [PDF]

Molecular and Cellular Biology, 1984
Each of two severely defective mouse kappa-chain genes has acquired a different intracisternal A particle (IAP) element within one of its introns. One IAP element generated 6-base-pair direct repeats upon insertion. In contrast, the other IAP element was not flanked by direct repeats and was missing a single nucleotide from its 3' terminus.
R G, Hawley, M J, Shulman, N, Hozumi
openaire   +2 more sources

Light chain nephropathy

Saudi Journal of Kidney Diseases and Transplantation, 2015
Light chain deposition disease (LCDD) is characterized by the tissue deposition of monotypic immunoglobulin light chains of either kappa or lambda isotype.
Sihem Darouich, Ilhem Bettaieb, Raja Aouadia, Hafedh Hedri, Ezzeddine Abderrahim, Rym Goucha, Adel Khedher   +6 more
doaj   +1 more source

Targeting Inflammation in the Diagnosis, Management, and Prevention of Cardiovascular Diseases

Global Heart, 2022
Inflammation plays an important role in the development and progression of cardiovascular diseases (CVDs). Hypertension and hyperlipidemia are the key risk factors of CVDs and induce inflammation in the heart and vessels.
Akira Matsumori
doaj   +1 more source

The disulphide bridges of immunoglobulin ϰ-chains [PDF]

Biochemical Journal, 1966
The arrangement of the disulphide bridges of the major component of the light chains of immunoglobulins (kappa-chains) has been studied in the Bence-Jones proteins. Three disulphide bridges have been found. An interchain bridge at the C-terminus has been shown to occur in the dimers of all the proteins studied and was characterized by symmetrical ...
openaire   +2 more sources

Sequences related to immunoglobulin kappa chain messenger RNA in T cells. [PDF]

Proceedings of the National Academy of Sciences, 1976
We investigated by molecular hybridization whether T cells contain RNA sequences homologous to RNA which codes for immunoglobulin kappa-chain (k-chain). A radioactive probe of complementary DNA (cDNA) was prepared by transcription of purified k-chain mRNA from mouse myeloma MOPC-41 with reverse transcriptase (RNA-dependent-DNA nucleotidyltransferase ...
U, Storb, L, Hager, D, Putnam, L, Buck, F, Farin, J, Clagett   +5 more
openaire   +2 more sources

Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy [PDF]

, 1984
Post-transplant lymphomas or other lymphoproliferative lesions, which were usually associated with Epstein-Barr virus infections, developed in 8, 4, 3, and 2 recipients, respectively, of cadaveric kidney, liver, heart, and heart-lung homografts ...
Atchison, RW, Bahnson, HT, Griffith, BP, Hakala, TR, Hardesty, RL, Ho, M, Iwatsuki, S, Jaffe, R, Nalesnik, MA, Porter, KA, Rosenthal, JT, Shaw, BW, Starzl, TE   +12 more
core   +1 more source

DNA sequence of the constant gene region of the mouse immunoglobulin kappa chain

Nucleic Acids Research, 1981
The constant (C; ref. 3) gene segment of the immunoglobulin kappa light chain and about 1 kb upstream as well as downstream of the segment have been sequenced. The sequences of the C gene segment itself and parts of the upstream region were determined both in liver and in myeloma T DNA clones derived from the same mouse inbred strain.
W, Altenburger, P S, Neumaier, M, Steinmetz, H G, Zachau   +3 more
openaire   +3 more sources

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Kaluzab, Brigitte, Schwirzke, Marina, Weidle, Ulrich H., Weiss, Elisabeth H., Weissenhorn, Winfried   +4 more
core   +1 more source