Results 21 to 30 of about 765,793 (291)

Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species

Frontiers in Immunology, 2022
Studies in humans and mice indicate the critical role of the surrogate light chain in the selection of the productive immunoglobulin repertoire during B cell development.
Marek Sinkora, Katerina Stepanova, John E. Butler, Marek Sinkora, Simon Sinkora, Jana Sinkorova   +5 more
doaj   +1 more source

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

mAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton   +7 more
doaj   +1 more source

Diagnosing a Challenging Case of Primary Amyloidosis using Capillary Electrophoresis [PDF]

National Journal of Laboratory Medicine, 2021
Amyloid Light chain (AL) amyloidosis is characterised by deposition of intact free light chains or their fragments in extracellular space. Here, authors describe the journey of a diagnostically challenging patient who presented with features of ...
rashmi verma, rajni saijpaul, Surbhi Garg, niharika jain, Vineeta V Batra   +4 more
doaj   +1 more source

Immune subtraction for improved resolution in serum protein immunofixation electrophoresis and antibody isotype determination in a patient with autoantibody

Practical Laboratory Medicine, 2021
Heavy chain isotypes of low level monoclonal immunoglobulins are sometimes obscured in serum immunofixation electrophoresis (SIFE) by a heavy background of polyclonal immunoglobulins.
Asad Ullah, Nivin Omar, Natasha M. Savage, Roni J. Bollag, Gurmukh Singh   +4 more
doaj   +1 more source

Localization, analysis and evolution of transposed human immunoglobulin VK genes [PDF]

, 1988
The localization of Vκ gene regions to chromosome 2, on which the κ locus is located, and to other chromosomes is described. The Vκ genes that have been transposed to other chromosomes are called orphons.
Klopstock, Thomas, Straubinger, Bernhard, Lötscher, Erika, Zachau, Hans G., Zimmer, Franz-Josef, Jaenichen, Rita, Grzeschik, Karl-Heinz   +6 more
core   +1 more source

Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus. [PDF]

Journal of Clinical Investigation, 1998
To determine whether receptor editing of Vkappa genes was involved in the pathogenesis of systemic lupus erythematosus (SLE), the usage of Vkappa and Jkappa gene elements from individual peripheral CD19(+) B cells obtained from a patient with untreated SLE was examined.
T, Dörner, S J, Foster, N L, Farner, P E, Lipsky   +3 more
openaire   +2 more sources

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Schwirzke, Marina, Kaluzab, Brigitte, Weissenhorn, Winfried, Weiss, Elisabeth H., Weidle, Ulrich H.   +4 more
core   +1 more source

The Role of Immunoglobulin Free Kappa Light Chains (FLCs) in Liver Cirrhosis [PDF]

Zagazig University Medical Journal
Background:Liver cirrhosis represents the end-stage of chronic liver disease, characterized by progressive fibrosis, architectural distortion, and declining hepatic function.
Sherif Galal, Eman El-Ahwany, Dina El-Nemr, Afnan Sarhan   +3 more
doaj   +1 more source

Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors [PDF]

OncoImmunology, 2012
Infiltration of plasma cells is associated with better prognosis in breast, lung and colon cancer. Immunoglobulin κ chain (IGKC) is now available as a single, robust immune marker predicting metastasis-free survival and response to chemotherapy. This will facilitate a deeper understanding of the role of the humoral immune system in cancer development.
Schmidt, Marcus, Micke, Patrick, Gehrmann, Mathias, Hengstler, Jan G.   +3 more
openaire   +2 more sources

A case of Fanconi syndrome accompanied by crystal depositions in tubular cells in a patient with multiple myeloma

Kidney Research and Clinical Practice, 2014
Fanconi syndrome (FS) is a rare condition that is characterized by defects in the proximal tubular function. A 48-year-old woman was admitted for evaluation of proteinuria.
Do Hee Kim, A Young Lim, Hye Bin Gwag, Ji Hyeon Lee, Ki Sun Jung, Keol Lee, Wooseong Huh, Dae Joong Kim, Yoon-Goo Kim, Ha Young Oh, Kihyun Kim, Gee-Young Kwon, Jung Eun Lee   +12 more
doaj   +1 more source