Results 11 to 20 of about 765,793 (291)

Idiotype-specific intravenous immunoglobulin for therapy of immunoglobulin kappa free light chain deficiency

Human Vaccines & Immunotherapeutics, 2019
Deficient antibody production in patients with common variable immunodeficiency (CVID) is accompanied by an inability to produce free light chains (FLCs), particularly kappa (κ) FLC, due to B-cell dysfunction.
Adina Elena Stanciu, Monica Popescu, Dan Cristian Gheorghe   +2 more
doaj   +2 more sources

Immunoglobulin kappa chain allotypes (KM) in onchocerciasis. [PDF]

Journal of Clinical Investigation, 1995
GM and KM allotypes, powerful tools for genetic characterization of human populations, have been shown to play an important role in genetic predisposition to some infectious diseases. Two diverse racial groups--Afro-Ecuadorians and Amerindians--living in a single restricted geographical area of Ecuador, appear to have different risk factors for ...
J P, Pandey, L H, Elson, S E, Sutherland, R H, Guderian, E, Araujo, T B, Nutman   +5 more
openaire   +2 more sources

Using cell-free RNA to identify B- and T-cell clonality for diagnosis and monitoring of B- and T-cell neoplasms. [PDF]

FEBS Open Bio
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Albitar A, Agersborg S, Charifa A, Phull P, Biran N, Vesole D, Parmar H, Pecora A, Ip A, Goy A, Siegel D, Albitar M.   +11 more
europepmc   +2 more sources

Pattern of serum immunoglobulins and free light chain levels among patients diagnosed with multiple myeloma in Southeast Nigeria

International Journal of Medicine and Health Development, 2023
Background: Abnormal plasma cells in multiple myeloma produce excessive amounts of immunoglobulins and free light chains, of which certain patterns predict patient survival.
Ifeyinwa D Nnakenyi, Anazoeze J Madu, Ifeoma C Ajuba, Sunday Ocheni, Gladys U Ilechukwu, Nnenna Ogbodo, Oji A Nnachi   +6 more
doaj   +1 more source

For Breast Cancer Prognosis, Immunoglobulin Kappa Chain Surfaces to the Top [PDF]

Clinical Cancer Research, 2012
Abstract The stromal immunoglobulin kappa chain (IGKC) has been validated as an immunologic biomarker of prognosis and response to therapy in human breast cancer and other cancers. This validation emphasizes the key role of humoral immunity in control of cancer progression and has major implications for determining prognosis of ...
Theresa L, Whiteside, Soldano, Ferrone
openaire   +2 more sources

Evolution of immunoglobulin kappa chain variable region genes in vertebrates [PDF]

Molecular Biology and Evolution, 1998
The major source of immunoglobulin diversity is variation in DNA sequence among multiple copies of variable region (V) genes of the heavy- and light-chain multigene families. In order to clarify the evolutionary pattern of the multigene family of immunoglobulin light kappa chain V region (V kappa) genes, phylogenetic analyses of V kappa genes from ...
T, Sitnikova, M, Nei
openaire   +2 more sources

Human Gm, Km, and Am Allotypes: WHO/IMGT Nomenclature and IMGT Unique Numbering for Immunoinformatics and Therapeutical Antibodies

BioMedInformatics, 2023
Human immunoglobulin allotypes are allelic antigenic determinants (or “markers”) determined serologically, classically by hemagglutination inhibition, on the human immunoglobulin (IG) or antibody heavy and light chains. The allotypes have been identified
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

The biology of immunoglobulin free light chains in kidney disease: a study of Monoclonal and Polyclonal light chains [PDF]

, 2012
Monoclonal immunoglobulin free light chains (FLCs) cause a range of disorders in the kidney. In multiple myeloma, FLCs can activate the proximal tubule to release MCP-1, an important cytokine in renal fibrosis.
Basnayake, Kolitha Indika
core   +7 more sources

High Inter-Individual Diversity of Point Mutations, Insertions, and Deletions in Human Influenza Virus Nucleoprotein-Specific Memory B Cells. [PDF]

PLoS ONE, 2015
The diversity of virus-specific antibodies and of B cells among different individuals is unknown. Using single-cell cloning of antibody genes, we generated recombinant human monoclonal antibodies from influenza nucleoprotein-specific memory B cells in ...
Sven Reiche, Yamen Dwai, Bianca M Bussmann, Susanne Horn, Michael Sieg, Christian Jassoy   +5 more
doaj   +1 more source

Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis. [PDF]

PLoS ONE, 2009
The amyloidoses are protein misfolding diseases characterized by the deposition of amyloid that leads to cell death and tissue degeneration. In immunoglobulin light chain amyloidosis (AL), each patient has a unique monoclonal immunoglobulin light chain ...
Tanya L Poshusta, Laura A Sikkink, Nelson Leung, Raynell J Clark, Angela Dispenzieri, Marina Ramirez-Alvarado   +5 more
doaj   +1 more source