Results 11 to 20 of about 74,618 (225)

Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus. [PDF]

Journal of Clinical Investigation, 1998
To determine whether receptor editing of Vkappa genes was involved in the pathogenesis of systemic lupus erythematosus (SLE), the usage of Vkappa and Jkappa gene elements from individual peripheral CD19(+) B cells obtained from a patient with untreated SLE was examined.
T, Dörner, S J, Foster, N L, Farner, P E, Lipsky   +3 more
openaire   +2 more sources

Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors [PDF]

OncoImmunology, 2012
Infiltration of plasma cells is associated with better prognosis in breast, lung and colon cancer. Immunoglobulin κ chain (IGKC) is now available as a single, robust immune marker predicting metastasis-free survival and response to chemotherapy. This will facilitate a deeper understanding of the role of the humoral immune system in cancer development.
Schmidt, Marcus, Micke, Patrick, Gehrmann, Mathias, Hengstler, Jan G.   +3 more
openaire   +2 more sources

Transposition of two different intracisternal A particle elements into an immunoglobulin kappa-chain gene. [PDF]

Molecular and Cellular Biology, 1984
Each of two severely defective mouse kappa-chain genes has acquired a different intracisternal A particle (IAP) element within one of its introns. One IAP element generated 6-base-pair direct repeats upon insertion. In contrast, the other IAP element was not flanked by direct repeats and was missing a single nucleotide from its 3' terminus.
R G, Hawley, M J, Shulman, N, Hozumi
openaire   +2 more sources

Significant Differences in Physicochemical Properties of Human Immunoglobulin Kappa and Lambda CDR3 Regions

Frontiers in Immunology, 2016
Antibody variable regions are composed of a heavy and a light chain, and in humans, there are two light chain isotypes: kappa and lambda. Despite their importance in receptor editing, the light chain is often overlooked in the antibody literature, with ...
Catherine Townsend, J. Laffy, Y. Wu, Joselli Silva O’Hare, Victoria G. Martin, D. Kipling, F. Fraternali, D. Dunn-Walters   +7 more
semanticscholar   +1 more source

The disulphide bridges of immunoglobulin ϰ-chains [PDF]

Biochemical Journal, 1966
The arrangement of the disulphide bridges of the major component of the light chains of immunoglobulins (kappa-chains) has been studied in the Bence-Jones proteins. Three disulphide bridges have been found. An interchain bridge at the C-terminus has been shown to occur in the dimers of all the proteins studied and was characterized by symmetrical ...
openaire   +2 more sources

Sequences related to immunoglobulin kappa chain messenger RNA in T cells. [PDF]

Proceedings of the National Academy of Sciences, 1976
We investigated by molecular hybridization whether T cells contain RNA sequences homologous to RNA which codes for immunoglobulin kappa-chain (k-chain). A radioactive probe of complementary DNA (cDNA) was prepared by transcription of purified k-chain mRNA from mouse myeloma MOPC-41 with reverse transcriptase (RNA-dependent-DNA nucleotidyltransferase ...
U, Storb, L, Hager, D, Putnam, L, Buck, F, Farin, J, Clagett   +5 more
openaire   +2 more sources

CSF Free Light Chains as a Marker of Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis: A Blood-CSF Barrier Related Evaluation in a Large Cohort

Frontiers in Immunology, 2019
Objectives: The importance of immunoglobulin G (IgG) oligoclonal bands (OCB) in the diagnosis of multiple sclerosis (MS) was reaffirmed again in the recently revised MS diagnostic criteria.
M. Senel, Fatemeh Mojib-Yezdani, U. Braisch, F. Bachhuber, J. Lewerenz, A. Ludolph, M. Otto, H. Tumani   +7 more
semanticscholar   +1 more source

DNA sequence of the constant gene region of the mouse immunoglobulin kappa chain

Nucleic Acids Research, 1981
The constant (C; ref. 3) gene segment of the immunoglobulin kappa light chain and about 1 kb upstream as well as downstream of the segment have been sequenced. The sequences of the C gene segment itself and parts of the upstream region were determined both in liver and in myeloma T DNA clones derived from the same mouse inbred strain.
W, Altenburger, P S, Neumaier, M, Steinmetz, H G, Zachau   +3 more
openaire   +3 more sources

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans. [PDF]

The EMBO Journal, 1993
Immunoglobulins (Ig) secreted from a plasma cell contain either kappa or lambda light chains, but not both. This phenomenon is termed isotypic kappa-lambda exclusion. While kappa-producing cells have their lambda chain genes in germline configuration, in most lambda-producing cells the kappa chain genes are either non-productively rearranged or deleted.
S, Takeda, Y R, Zou, H, Bluethmann, D, Kitamura, U, Muller, K, Rajewsky   +5 more
openaire   +2 more sources

The active immunoglobulin kappa chain gene is packaged by non-ubiquitin-conjugated nucleosomes. [PDF]

Proceedings of the National Academy of Sciences, 1986
To elucidate the molecular features of active chromatin, we have mapped, by two-dimensional electrophoresis, the protein composition of nucleosomes that package the immunoglobulin kappa chain gene of mouse plasmacytoma cells. Nucleoprotein particles that possess the active kappa chain gene comigrate with bulk mononucleosomes that contain high mobility ...
S Y, Huang, M B, Barnard, M, Xu, S, Matsui, S M, Rose, W T, Garrard   +5 more
openaire   +2 more sources