Results 41 to 50 of about 765,793 (291)

Peripheral Neuropathy and VIth Nerve Palsy Related to Randall Disease Successfully Treated by High-Dose Melphalan, Autologous Blood Stem Cell Transplantation, and VIth Nerve Decompression Surgery

Case Reports in Medicine, 2010
Randall disease is an unusual cause of extraocular motor nerve (VI) palsy. A 35-year-old woman was hospitalized for sicca syndrome. The physical examination showed general weakness, weight loss, diplopia related to a left VIth nerve palsy, hypertrophy of
C. Foguem, P. Manckoundia, P. Pfitzenmeyer, J.-L. Dupond   +3 more
doaj   +1 more source

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans. [PDF]

The EMBO Journal, 1993
Immunoglobulins (Ig) secreted from a plasma cell contain either kappa or lambda light chains, but not both. This phenomenon is termed isotypic kappa-lambda exclusion. While kappa-producing cells have their lambda chain genes in germline configuration, in most lambda-producing cells the kappa chain genes are either non-productively rearranged or deleted.
S, Takeda, Y R, Zou, H, Bluethmann, D, Kitamura, U, Muller, K, Rajewsky   +5 more
openaire   +2 more sources

The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]

, 2003
We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Santoro, Aniello, Nuttall, James, Ma, Julian K.-C., Vitale, A. (Alessandro), Hadlington, Jane L., Frigerio, Lorenzo, Denecke, J. (Jurgen)   +6 more
core   +1 more source

Concordance rate between oligoclonal bands and the Kappa index in patients with suspected multiple sclerosis (MS)

Arquivos de Neuro-Psiquiatria
Background Oligoclonal bands (OCBs) and Kappa free light chains (FLCs) in the cerebrospinal fluid (CSF) are sensitive markers of intrathecal immunoglobulin (Ig)G synthesis in patients with multiple sclerosis.
Renan Barros Domingues, Márcio Vega dos Santos, Daiane Salomão, Carlos Senne   +3 more
doaj   +1 more source

The active immunoglobulin kappa chain gene is packaged by non-ubiquitin-conjugated nucleosomes. [PDF]

Proceedings of the National Academy of Sciences, 1986
To elucidate the molecular features of active chromatin, we have mapped, by two-dimensional electrophoresis, the protein composition of nucleosomes that package the immunoglobulin kappa chain gene of mouse plasmacytoma cells. Nucleoprotein particles that possess the active kappa chain gene comigrate with bulk mononucleosomes that contain high mobility ...
S Y, Huang, M B, Barnard, M, Xu, S, Matsui, S M, Rose, W T, Garrard   +5 more
openaire   +2 more sources

Laboratory biomarkers for multiple sclerosis and their role in clinical practice

Neurologijos seminarai, 2023
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) most commonly diagnosed in young adults. In recent decades, new treatments have emerged that have radically changed the prognosis and quality of life of these patients ...
I. Navickaitë, G. Žemgulytė, R. Balnytė   +2 more
doaj   +3 more sources

A Synthetic β‐Mannan Epitope Enables Immunization and Detection of Candida auris

Angewandte Chemie, EarlyView.
A synthetic β‐mannan epitope enables both active and passive immunization against Candida auris. Conjugation to the carrier protein CRM197 induces protective antibody responses, while monoclonal antibodies targeting the same epitope support detection using a lateral flow assay, linking glycochemistry with antifungal prevention and diagnostics ...
Emelie E. Reuber, Arnab Pradhan, Ian Leaves, Rajat K. Singh, Emer Hickey, Carola Geiler, Neil A. R. Gow, Alistair J. P. Brown, Peter H. Seeberger   +8 more
wiley   +2 more sources

Kappa Index versus CSF Oligoclonal Bands in Predicting Multiple Sclerosis and Infectious/Inflammatory CNS Disorders

Diagnostics, 2020
Background: Cerebrospinal fluid (CSF) kappa free light chains (KFLC) are gaining increasing interest as markers of intrathecal immunoglobulin synthesis. The main aim of this study was to assess the diagnostic accuracy (AUC) of the kappa index (CSF/serum ...
Diana Ferraro, Roberta Bedin, Patrizia Natali, Diego Franciotta, Krzysztof Smolik, Mario Santangelo, Paolo Immovilli, Valentina Camera, Francesca Vitetta, Matteo Gastaldi, Tommaso Trenti, Stefano Meletti, Patrizia Sola   +12 more
doaj   +1 more source

Double recombination of a single immunoglobulin kappa-chain allele: implications for the mechanism of rearrangement. [PDF]

Proceedings of the National Academy of Sciences, 1985
DNA fragments containing immunoglobulin kappa-chain sequences from two different plasmacytomas (PC 3609 and PC 7043) were found by blot-hybridization studies to be dissociated from germ-line sequences on both the 3' and 5' ends. These fragments were cloned, sequenced, and found to contain the structural features of a product of two recombination events.
R M, Feddersen, B G, Van Ness
openaire   +2 more sources

Assessment of Serum Free Light Chains as a Marker of Diabetic Nephropathy; A Cross-Sectional Study in the Kumasi Metropolis

Frontiers in Clinical Diabetes and Healthcare, 2022
AimsAlthough traditional tests such as serum urea, creatinine, and microalbuminuria have been widely employed in the diagnosis of diabetic nephropathy, their sensitivity and accuracy are limited because kidney damage precedes the excretion of these ...
Elizabeth Sorvor, Elizabeth Sorvor, William K. B. A. Owiredu, Perditer Okyere, Perditer Okyere, Max Efui Annani-Akollor, Sampson Donkor, Richard Bannor, Richard Bannor, Felix B.K. Sorvor, Richard K.D. Ephraim   +10 more
doaj   +1 more source