Results 51 to 60 of about 765,793 (291)
, 2011 Bekanntermaßen haben Patienten mit chronischer Niereninsuffizienz eine erhöhte Morbidität und Mortalität. In der vorliegenden Untersuchung wurde geprüft, ob die Serumkonzentrationen an freien Leichtketten Kappa und Lambda prädiktive Faktoren für das ...
Caspari, Cristina Angelina
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Data from For Breast Cancer Prognosis, Immunoglobulin Kappa Chain Surfaces to the Top
, 2023 <div>Abstract<p>The stromal immunoglobulin kappa chain (IGKC) has been validated as an immunologic biomarker of prognosis and response to therapy in human breast cancer and other cancers. This validation emphasizes the key role of humoral immunity in control of cancer progression and has major implications for determining prognosis of ...
Soldano Ferrone, Theresa L. Whiteside
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Identification and functional characterization of the novel MAR-binding protein, SATB2 [PDF]
, 2004 The regulation of gene expression is governed in large part by transcription factors that bind to enhancers and promoters. The functions of transcription factors involve both the modulation of chromatin accessibility via the recruitment of histone ...
Dobreva, Gergana
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Clinical Characteristics and Concordance of Anti‐MDA5 Antibodies: A Multicenter Australian Study
Arthritis Care &Research, EarlyView.Objective In Australia, anti‐MDA5 antibodies are exclusively tested by a line immunoblot assay (LIA). The clinical concordance of an LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies. Methods Electronic records of a multisite cohort (patients
Syed B. Ali +11 more
wiley +1 more source
Renal Expression of Light Chain Binding Proteins
Frontiers in Medicine, 2021 Overproduction of human light chains (LCs) and immunoglobulins can result in various forms of renal disease such as cast nephropathy, monoclonal immunoglobulin deposition disease, LC proximal tubulopathy, AL amyloidosis, and crystal storing histiocytosis.
Thomas Reiter +11 more
doaj +1 more source
B lymphocyte-specific protein binding near an immunoglobulin kappa-chain gene J segment. [PDF]
Proceedings of the National Academy of Sciences, 1987 Nuclear extracts from pre-B and B cell lines contain a nuclear DNA binding protein (kappa locus protein, KLP) that specifically recognizes a DNA sequence in the immunoglobulin kappa light chain joining (J) segment gene region. KLP is not observed in mature B cells, T cells, or nonlymphoid cell types.
Weaver, David, Baltimore, David
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C-myc and immunoglobulin kappa light chain constant genes are on the 8q+ chromosome of three Burkitt lymphoma lines with t(2;8) translocations [PDF]
, 1984 We have determined the localization of c-myc and the immunoglobulin kappa light chain genes on the 8q+/2p- chromosomes of the three Burkitt lymphoma lines BL21, LY66 and LY91 with t(2;8) translocation by in situ hybridization.
Cremer, Thomas +7 more
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Multiple-alphabet amino acid sequence comparisons of the immunoglobulin kappa-chain constant domain. [PDF]
Proceedings of the National Academy of Sciences, 1985 We compare the amino acid sequences of the constant domains of the immunoglobulin kappa chain of human, mouse, and rabbit by using four classification schemes ("alphabets") of the 20 amino acids based on their chemical, functional, charge, and structural properties. The comparison reveals three regions of pronounced similarity across the three species,
S, Karlin, G, Ghandour
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Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light
Advanced Science, EarlyView.Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley +1 more source
Case Reports in Nephrology and Dialysis, 2020 Many challenges remain in diagnosing monoclonal immunoglobulin-associated renal disease, despite widespread application of immunofluorescence (IF) and immunohistochemistry.
Zi Yun Chang +4 more
doaj +1 more source