Results 11 to 20 of about 50,405 (295)
Systemic immunoglobulin light chain amyloidosis [PDF]
Nature Reviews Disease Primers, 2018 Systemic immunoglobulin light chain amyloidosis is a protein misfolding disease caused by the conversion of immunoglobulin light chains from their soluble functional states into highly organized amyloid fibrillar aggregates that lead to organ dysfunction.
Merlini G. +6 more
openaire +6 more sources
Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]
PeerJ, 2023 The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova +4 more
doaj +2 more sources
Solitary ulcerated plaque on the face - an unusual presentation of cutaneous plasmacytosis? [PDF]
Anais Brasileiros de Dermatologia, 2017 Cutaneous and systemic plasmacytosis is a rare disorder characterized by cutaneous polyclonal plasma cell infiltration frequently associated with polyclonal hypergammaglobulinemia and lymphadenopathy.
Ana Marta António +3 more
doaj +1 more source
Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis
Hemato, 2021 Non-native immunoglobulin light chain conformations, including aggregates, appear to cause light chain amyloidosis pathology. Despite significant progress in pharmacological eradication of the neoplastic plasma cells that secrete these light chains, in ...
Gareth J. Morgan +2 more
doaj +1 more source
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]
PLoS ONE, 2014 Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita +7 more
doaj +1 more source
Mechanisms of Organ Damage and Novel Treatment Targets in AL Amyloidosis
Hemato, 2022 The deposition of amyloid light chains (LCs) in target sites translates into tissue damage and organ dysfunction. Clinical and experimental advances have cast new light on the pathophysiology of damage in AL amyloidosis.
Francesca Lavatelli
doaj +1 more source
, 2023 In immunoglobulin light chain amyloidosis, unstable immunoglobulin light chains aggregate as amyloid fibrils in organs, leading to organ failure and death in more than 50% of untreated patients. Research by Morgan et al. (Morgan, G. J. et.
Jonas, Jeppesen +3 more
core +1 more source
PROPERTIES OF HALVES OF IMMUNOGLOBULIN LIGHT CHAINS [PDF]
Proceedings of the National Academy of Sciences, 1969 Light polypeptide chains from both normal human γG immunoglobulin and Bence-Jones proteins can be cleaved into halves by limited proteolysis with trypsin, pepsin, or papain. The fragments were obtained in yields of up to 22 per cent, had molecular weights of 10,000 to 11,000, and were shown by amino acid analysis and antigenic analysis to correspond to
F A, Karlsson +2 more
openaire +2 more sources
مجله دانشکده پزشکی اصفهان, 2018 Background: Non-Hodgkin lymphoma is the most common cancer in the world. This study aimed to determine the correlation between the serum level of free light chain ratio and age, and subtype and stage of the disease.
Farzaneh Ashrafi +2 more
doaj +1 more source
Localization, analysis and evolution of transposed human immunoglobulin VK genes [PDF]
, 1988 The localization of Vκ gene regions to chromosome 2, on which the κ locus is located, and to other chromosomes is described. The Vκ genes that have been transposed to other chromosomes are called orphons.
Klopstock, Thomas +6 more
core +1 more source