Results 41 to 50 of about 50,405 (295)
RNAseq results using kidney cortex from mice receiving human immunoglobulin light chains
, 2021 We hypothesized that immunoglobulin free light chains (FLC) generated oxidative stress in the kidney and promoted significant changes in RNA expression when compared to vehicle treated control mice.
Sanders, P (via Mendeley Data)
core +2 more sources
Clinical Immunology CommunicationsObjectives: The objective of this study is to evaluate the use of the immunoglobulin heavy/light chain biomarker in the early detection of biochemical relapse in patients with multiple myeloma under treatment.
Carla Azevedo +11 more
doaj +1 more source
In Silico Prediction of Continuous Epitopes on Human immunoglobulin Light Chains [PDF]
Journal of Advanced Biomedical Sciences, 2020 Background & Objective: Immunoglobulins (Igs) have a vital role in body protection against germs. Igs contain heavy and light chains. Ig light chains consist of two isotypes: Kappa and lambda.
Soheyla Rohani, Fatemeh Hajighasemi
doaj
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2009 La nefropatía de las gammapatías monoclonales es debida, principalmente, al depósito de cadenas ligeras. Las enfermedades renales paraproteinémicas son lesiones asociadas con depósitos de inmunoglobulinas intactas o fragmentos de inmunoglobulinas ...
Jorge de Jesús Cantillo +2 more
doaj +1 more source
, 2011 <i>Background/Aims:</i> Impaired immune function is common in patients with chronic renal failure. Now, we determined whether serum levels of free immunoglobulin light chains predict mortality in patients with chronic kidney disease stage 5 ...
Martin Tepel +7 more
core +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Amyloidogenicity of Immunoglobulin Light Chains [PDF]
Biophysical Journal, 2015 Systemic light chain amyloidosis (AL) is a rare protein aggregation disease. It usually strikes in the wake of myeloma, which affects plasma cells in the adaptive immune system. During plasma cell development, the immunoglobulin light chain (LC) genes undergo several rearrangements that leave each clone with a unique protein sequence.
Andrich, Kathrin +4 more
openaire +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Cutaneous amyloidosis as the first presentation of Waldenstrom macroglobulinemia
Caspian Journal of Internal Medicine, 2020 Background: Waldenstrom macroglobulinemia is a lymphoplasmacytic lymphoma with elevated serum immunoglobulin M and multi-organ involvement. Primary systemic amyloidosis usually develops due to immunoglobulin light chains depositions in different organs ...
Rana Rafiei +2 more
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