Results 41 to 50 of about 3,969,240 (284)

Recommendations for use of free light chain assay in monoclonal gammopathies [PDF]

Journal of Medical Biochemistry, 2010
The serum immunoglobulin free light chain assay measures levels of free k and l immunoglobulin light chains. There are three major indications for the free light chain assay in the evaluation and management of multiple myeloma and related plasma cell ...
Radović Vesna V.
doaj  

Comparative Aspects of Immunoglobulin Gene Rearrangement Arrays in Different Species

Frontiers in Immunology, 2022
Studies in humans and mice indicate the critical role of the surrogate light chain in the selection of the productive immunoglobulin repertoire during B cell development.
Marek Sinkora, Katerina Stepanova, John E. Butler, Marek Sinkora, Simon Sinkora, Jana Sinkorova   +5 more
doaj   +1 more source

Human Gm, Km, and Am Allotypes: WHO/IMGT Nomenclature and IMGT Unique Numbering for Immunoinformatics and Therapeutical Antibodies

BioMedInformatics, 2023
Human immunoglobulin allotypes are allelic antigenic determinants (or “markers”) determined serologically, classically by hemagglutination inhibition, on the human immunoglobulin (IG) or antibody heavy and light chains. The allotypes have been identified
Marie-Paule Lefranc, Gérard Lefranc
doaj   +1 more source

Immunoglobulin Light Chain Amyloidosis

Mayo Clinic Proceedings
ABSTRACT Symmetric, purpuric hand nodules and macroglossia prompted skin biopsy revealing immunoglobulin light chain amyloidosis, leading to the diagnosis of multiple myeloma. Early detection of typical and atypical cutaneous amyloidosis presentations, such as this patient, is imperative for clinicians to initiate timely hematologic ...
Mahin Bhatt, Dragan Jevremovic, S. Vincent Rajkumar   +2 more
openaire   +3 more sources

Evaluating the heavy/light chain immunoglobulin biomarker for early relapse detection in multiple myeloma: A comparative study with conventional methods

Clinical Immunology Communications
Objectives: The objective of this study is to evaluate the use of the immunoglobulin heavy/light chain biomarker in the early detection of biochemical relapse in patients with multiple myeloma under treatment.
Carla Azevedo, Ana Catarina Fonseca, João Pedro Barreto, Ana Marta Pires, Carina Faria, Andreia Pinto, Maria Emília Sousa, Carlos Palmeira, Cristina Prudêncio, Bruno Fernandes, Gabriela Martins, Ricardo Ferraz   +11 more
doaj   +1 more source

In Silico Prediction of Continuous Epitopes on Human immunoglobulin Light Chains [PDF]

Journal of Advanced Biomedical Sciences, 2020
Background & Objective: Immunoglobulins (Igs) have a vital role in body protection against germs. Igs contain heavy and light chains. Ig light chains consist of two isotypes: Kappa and lambda.
Soheyla Rohani, Fatemeh Hajighasemi
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Nefropatía no amiloidea por depósito de inmunoglobulinas monoclonales A propósito de un caso de enfermedad idiopática por depósito de cadenas ligeras

Biomédica: revista del Instituto Nacional de Salud, 2009
La nefropatía de las gammapatías monoclonales es debida, principalmente, al depósito de cadenas ligeras. Las enfermedades renales paraproteinémicas son lesiones asociadas con depósitos de inmunoglobulinas intactas o fragmentos de inmunoglobulinas ...
Jorge de Jesús Cantillo, Rocío del Pilar López, Rafael Enrique Andrade   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source