Results 51 to 60 of about 50,405 (295)

Novel Biomarkers of Inflammation for the Management of Diabetes: Immunoglobulin-Free Light Chains

Biomedicines, 2022
Virus infection, inflammation and genetic factors are important factors in the pathogenesis of diabetes mellitus. The nuclear factor-kappa B (NF-κB) is a family of transcription factors that bind the enhancer of the κ light chain gene of B cell ...
Akira Matsumori
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Simultaneous tubular and glomerular involvement with cryoglobulinemia vasculitis in multiple myeloma

Saudi Journal of Kidney Diseases and Transplantation, 2019
Renal manifestations in myeloma are varied. Tubulopathic light chains cause cast nephropathy or proximal tubulopathy, usually associated with tubulointerstitial nephritis.
Zafirah Zahir, Vinita Agrawal, Asif Sadiq Wani, Narayan Prasad   +3 more
doaj   +1 more source

Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses

, 2002
Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Redegeld FA, van der Heijden MW, Kool M, Heijdra BM, Garssen J, Kraneveld AD, Van Loveren H, Roholl P, Saito T, Verbeek JS, Claassens J, Koster AS, Nijkamp FP.
Koster, A.S., van Loveren, H., Claassens, J., Kool, M., Heijdra, B.M., Nijkamp, F.P., Rhoholl, P., van der Heijden, M.W., Garssen, J., Saito, T., Verbeek, S., Kraneveld, A.D., Redegeld, F.A.   +12 more
core   +1 more source

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Heterohybridomas producing human immunoglobulin light chains using CD138-selected bone marrow cells

Biochemistry and Biophysics Reports
Background: Light chain research is hampered by lack of mammalian cell lines producing human light chains (FLC). Therefore, we used heterohybridoma (HH) technology to produce clones making FLC thereby providing tools to study light chain behavior ...
P. Zhou, X. Ma, S. Scalia, D. Toskic, X. Wu, T. Fogaren, Nancy Coady Lyons, Luis del Pozo-Yauner, R.L. Comenzo   +8 more
doaj   +1 more source

Immunoglobulin genes and diversity: what we have learned from domestic animals

Journal of Animal Science and Biotechnology, 2012
This review focuses on the diversity of immunoglobulin (Ig) genes and Ig isotypes that are expressed in domestic animals. Four livestock species—cattle, sheep, pigs, and horses—express a full range of Ig heavy chains (IgHs), including μ, δ, γ, ϵ, and α ...
Sun Yi, Liu Zhancai, Ren Liming, Wei Zhiguo, Wang Ping, Li Ning, Zhao Yaofeng   +6 more
doaj   +1 more source

Diverse patterns of antibody variable gene repertoire disruption in patients with amyloid light chain (AL) amyloidosis.

PLoS ONE, 2020
Immunoglobulin light chain amyloidosis is the most common form of systemic amyloidosis. AL amyloidosis is caused by a misfolded light chain produced by a clonal population of plasma cells.
Elaine C Chen, Samuel Rubinstein, Cinque Soto, Robin G Bombardi, Samuel B Day, Luke Myers, Alexey Zaytsev, Mahsa Majedi, R Frank Cornell, James E Crowe   +9 more
doaj   +1 more source

The biology of immunoglobulin free light chains and kidney injury

, 2011
Kidney injury caused by immunoglobulin free light chains (FLCs) in the setting of plasma cell dyscrasias is common and associated with increased morbidity and mortality.
Hutchison, Colin A., Stringer, Stephanie, Hutchison, CA, Paul Cockwell, Kolitha Basnayake, Stephanie J. Stringer, Basnayake, Kolitha, Cockwell, Paul, Stringer, Stephanie J., Colin A. Hutchison   +9 more
core   +1 more source