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Immunoglobulin light chain amyloidosis [PDF]

memo - Magazine of European Medical Oncology, 2021
SummaryImmunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed life-threatening systemic disease, primarily caused by insoluble depositions of misfolded monoclonal light chains. The monoclonal light chain paraprotein originates from a small clonal B‑cell or a clonal plasma cell population.
Hermine Agis, Maria T. Krauth
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Immunoglobulin light chain amyloid aggregation [PDF]

Chemical Communications, 2018
Light chain (AL) amyloidosis is a devastating, complex, and incurable protein misfolding disease.
Luis M. Blancas-Mejia, Pinaki Misra, Christopher J. Dick, Shawna A. Cooper, Keely R. Redhage, Michael R. Bergman, Torri L. Jordan, Khansaa Maar, Marina Ramirez-Alvarado   +8 more
openaire   +2 more sources

Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]

, 1991
We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Schwirzke, Marina, Kaluzab, Brigitte, Weissenhorn, Winfried, Weiss, Elisabeth H., Weidle, Ulrich H.   +4 more
core   +1 more source

Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics

Nature Communications, 2022
Immunoglobulin light chain amyloidosis is a lethal hematologic disorder driven by clonal plasma cells producing abnormal light chains that damage healthy tissues. Fraser et al.
Cameron S. Fraser, Johan K. E. Spetz, Xingping Qin, Adam Presser, Jonathan Choiniere, Chendi Li, Stacey Yu, Frances Blevins, Aaron N. Hata, Jeffrey W. Miller, Gary A. Bradshaw, Marian Kalocsay, Vaishali Sanchorawala, Shayna Sarosiek, Kristopher A. Sarosiek   +14 more
doaj   +1 more source

Producing amyloid fibrils in vitro: A tool for studying AL amyloidosis

Biochemistry and Biophysics Reports, 2023
Amyloid light-chain (AL) amyloidosis is the second most common form of systemic amyloidosis which is characterized by a high level of mortality and no effective treatment to remove fibril deposition.
Daria V. Sizova, Steve Raiker, Deaneira Lakheram, Vishwanatha Rao, Andrew Proffitt, Yazen Jmeian, Walter Voegtli, Melissa Batonick   +7 more
doaj   +1 more source

The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]

, 2003
We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Santoro, Aniello, Nuttall, James, Ma, Julian K.-C., Vitale, A. (Alessandro), Hadlington, Jane L., Frigerio, Lorenzo, Denecke, J. (Jurgen)   +6 more
core   +1 more source

Biomarkers in Immunoglobulin Light Chain Amyloidosis

Klinicka Onkologie, 2017
Immunoglobulin light chain amyloidosis (AL amyloidosis - ALA) is a monoclonal gammopathy characterized by presence of aberrant plasma cells producing amyloidogenic immunoglobulin light chains. This leads to formation of amyloid fibrils in various organs and tissues, mainly in heart and kidney, and causes their dysfunction.
Kufova, Z., Sevcikova, T., Growkova, K., Vojta, P., Filipova, J., Adam, Z., Pour, L., Penka, M., Rysava, R., Nemec, P., Brozova, L., Vychytilova, P., Jurczyszyn, Artur, Grosicki, S., Barchnicka, A., Hajduch, M., Simicek, M., Hajek, R.   +17 more
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Immunoglobulin light chain amyloidosis and the kidney [PDF]

Kidney International, 2002
Immunoglobulin light chain amyloidosis and the kidney. Amyloidosis (AL) is a common cause of nephrotic syndrome in nondiabetic, nonhypertensive adults. All adult patients with nephrotic syndrome should have immunofixation of serum and urine as a screen.
Gertz, Morie A., Lacy, Martha Q., Dispenzieri, Angela   +2 more
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Pattern of serum immunoglobulins and free light chain levels among patients diagnosed with multiple myeloma in Southeast Nigeria

International Journal of Medicine and Health Development, 2023
Background: Abnormal plasma cells in multiple myeloma produce excessive amounts of immunoglobulins and free light chains, of which certain patterns predict patient survival.
Ifeyinwa D Nnakenyi, Anazoeze J Madu, Ifeoma C Ajuba, Sunday Ocheni, Gladys U Ilechukwu, Nnenna Ogbodo, Oji A Nnachi   +6 more
doaj   +1 more source

Elevated serum polyclonal immunoglobulin free light chains in patients with severe asthma

Frontiers in Pharmacology, 2023
Background: Inflammation plays a pivotal role in the pathophysiology of asthma. Free light chains (FLC) can cause inflammation by mast cell antigen-activation. Serum immunoglobulin (Ig) FLC κ, but not λ, were shown elevated in adult males with asthma. We
Umberto Basile, Umberto Basile, Giuseppe Santini, Giuseppe Santini, Cecilia Napodano, Giuseppe Macis, Krizia Pocino, Francesca Gulli, Mario Malerba, Andrew Bush, Ian M. Adcock, Paolo Montuschi, Paolo Montuschi   +12 more
doaj   +1 more source