Results 21 to 30 of about 3,969,240 (284)
Mechanisms of Organ Damage and Novel Treatment Targets in AL Amyloidosis
Hemato, 2022 The deposition of amyloid light chains (LCs) in target sites translates into tissue damage and organ dysfunction. Clinical and experimental advances have cast new light on the pathophysiology of damage in AL amyloidosis.
Francesca Lavatelli
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Immunoglobulin light chain amyloidosis and the kidney [PDF]
Kidney International, 2002 Immunoglobulin light chain amyloidosis and the kidney. Amyloidosis (AL) is a common cause of nephrotic syndrome in nondiabetic, nonhypertensive adults. All adult patients with nephrotic syndrome should have immunofixation of serum and urine as a screen.
Gertz, Morie A. +2 more
openaire +2 more sources
مجله دانشکده پزشکی اصفهان, 2018 Background: Non-Hodgkin lymphoma is the most common cancer in the world. This study aimed to determine the correlation between the serum level of free light chain ratio and age, and subtype and stage of the disease.
Farzaneh Ashrafi +2 more
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Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]
, 1991 We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Schwirzke, Marina +4 more
core +1 more source
Localization, analysis and evolution of transposed human immunoglobulin VK genes [PDF]
, 1988 The localization of Vκ gene regions to chromosome 2, on which the κ locus is located, and to other chromosomes is described. The Vκ genes that have been transposed to other chromosomes are called orphons.
Klopstock, Thomas +6 more
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Immunoglobulin light chain amyloid aggregation [PDF]
Chemical Communications, 2018 Light chain (AL) amyloidosis is a devastating, complex, and incurable protein misfolding disease.
Luis M. Blancas-Mejia +8 more
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PROPERTIES OF HALVES OF IMMUNOGLOBULIN LIGHT CHAINS [PDF]
Proceedings of the National Academy of Sciences, 1969 Light polypeptide chains from both normal human γG immunoglobulin and Bence-Jones proteins can be cleaved into halves by limited proteolysis with trypsin, pepsin, or papain. The fragments were obtained in yields of up to 22 per cent, had molecular weights of 10,000 to 11,000, and were shown by amino acid analysis and antigenic analysis to correspond to
F A, Karlsson +2 more
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Nature Communications, 2022 Immunoglobulin light chain amyloidosis is a lethal hematologic disorder driven by clonal plasma cells producing abnormal light chains that damage healthy tissues. Fraser et al.
Cameron S. Fraser +14 more
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The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole [PDF]
, 2003 We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells.
Santoro, Aniello +6 more
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Producing amyloid fibrils in vitro: A tool for studying AL amyloidosis
Biochemistry and Biophysics Reports, 2023 Amyloid light-chain (AL) amyloidosis is the second most common form of systemic amyloidosis which is characterized by a high level of mortality and no effective treatment to remove fibril deposition.
Daria V. Sizova +7 more
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