Solitary ulcerated plaque on the face - an unusual presentation of cutaneous plasmacytosis? [PDF]
Anais Brasileiros de Dermatologia, 2017 Cutaneous and systemic plasmacytosis is a rare disorder characterized by cutaneous polyclonal plasma cell infiltration frequently associated with polyclonal hypergammaglobulinemia and lymphadenopathy.
Ana Marta António +3 more
doaj +1 more source
Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis
Hemato, 2021 Non-native immunoglobulin light chain conformations, including aggregates, appear to cause light chain amyloidosis pathology. Despite significant progress in pharmacological eradication of the neoplastic plasma cells that secrete these light chains, in ...
Gareth J. Morgan +2 more
doaj +1 more source
Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production. [PDF]
PLoS ONE, 2014 Towards the goal of producing fully human polyclonal antibodies (hpAbs or hIgGs) in transchromosomic (Tc) cattle, we previously reported that Tc cattle carrying a human artificial chromosome (HAC) comprising the entire unrearranged human immunoglobulin ...
Hiroaki Matsushita +7 more
doaj +1 more source
Immunoglobulin light chain amyloid aggregation [PDF]
Chemical Communications, 2018 Light chain (AL) amyloidosis is a devastating, complex, and incurable protein misfolding disease.
Luis M. Blancas-Mejia +8 more
openaire +2 more sources
Mutations in specific structural regions of immunoglobulin light chains are associated with free light chain levels in patients with AL amyloidosis. [PDF]
PLoS ONE, 2009 The amyloidoses are protein misfolding diseases characterized by the deposition of amyloid that leads to cell death and tissue degeneration. In immunoglobulin light chain amyloidosis (AL), each patient has a unique monoclonal immunoglobulin light chain ...
Tanya L Poshusta +5 more
doaj +1 more source
Mechanisms of Organ Damage and Novel Treatment Targets in AL Amyloidosis
Hemato, 2022 The deposition of amyloid light chains (LCs) in target sites translates into tissue damage and organ dysfunction. Clinical and experimental advances have cast new light on the pathophysiology of damage in AL amyloidosis.
Francesca Lavatelli
doaj +1 more source
مجله دانشکده پزشکی اصفهان, 2018 Background: Non-Hodgkin lymphoma is the most common cancer in the world. This study aimed to determine the correlation between the serum level of free light chain ratio and age, and subtype and stage of the disease.
Farzaneh Ashrafi +2 more
doaj +1 more source
Higher Serum Levels of Free ĸ plus λ Immunoglobulin Light Chains Ameliorate Survival of Hemodialysis Patients [PDF]
, 2011 <i>Background/Aims:</i> Impaired immune function is common in patients with chronic renal failure. Now, we determined whether serum levels of free immunoglobulin light chains predict mortality in patients with chronic kidney disease stage 5 ...
Caspari, Christina +3 more
core +1 more source
Diversity of immunoglobulin light chain genes in non-teleost ray-finned fish uncovers IgL subdivision into five ancient isotypes [PDF]
, 2018 The aim of this study was to fill important gaps in the evolutionary history of immunoglobulins by examining the structure and diversity of IgL genes in non-teleost ray-finned fish.
Andreyushkova, Daria A +14 more
core +5 more sources
Nature Communications, 2022 Immunoglobulin light chain amyloidosis is a lethal hematologic disorder driven by clonal plasma cells producing abnormal light chains that damage healthy tissues. Fraser et al.
Cameron S. Fraser +14 more
doaj +1 more source