Results 191 to 200 of about 118,116 (256)

Diagnostic Utility of Relative Apical Sparing Index in Cardiac Amyloidosis Subtypes: A Comparative Study of Immunoglobulin Light Chain and Transthyretin Amyloid Cardiomyopathy. [PDF]

Echocardiography
Saijo Y, Yamada H, Yamaguchi N, Nishio S, Zheng R, Takahashi T, Hara T, Kadota M, Kawabata Y, Ueno R, Matsuura T, Ise T, Yamaguchi K, Yagi S, Soeki T, Wakatsuki T, Sata M.   +16 more
europepmc   +1 more source

Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V[subscript L]–J[subscript L–C[subscript L) gene clusters

, 2007
Anastasia M. Zimmerman, G Yeo, Kerstin Howe, Benjamin J. Maddox, Lisa A. Steiner   +4 more
openalex   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Immunoglobulin light chain mutational status refines IGHV prognostic value in identifying chronic lymphocytic leukemia patients with early treatment requirement. [PDF]

Leukemia
Nabki J, Al Deeban B, Sium AM, Cosentino C, Almasri M, Awikeh B, Maher N, Bellia M, Dondolin R, Mouhssine S, Talotta D, Secomandi E, Kogila S, Ghanej J, Maiellaro F, Cividini L, Rasi S, Chiarenza A, Olivieri J, Gentile M, Zaja F, Del Principe MI, Laurenti L, Bomben R, Vit F, Bittolo T, Zucchetto A, Gattei V, Gaidano G, Moia R.   +29 more
europepmc   +1 more source

Long-term risk of myelodysplasia in melphalan-treated patients with immunoglobulin light-chain amyloidosis

, 2008
MA Gertz, M. Q. Lacy, John A. Lust, PR Greipp, T.E. Witzig, Robert A. Kyle   +5 more
openalex   +2 more sources

Targets of somatic hypermutation within immunoglobulin light chain genes in zebrafish [PDF]

, 2010
Alexis E. Marianes, Anastasia M. Zimmerman   +1 more
openalex   +1 more source

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Prognostic factors in Chinese patients with immunoglobulin light chain amyloidosis: a scoping review and meta-analysis. [PDF]

Ann Med
Wu Y, Wang X, Gào X, Xu L, Wang B, Cai Z.   +5 more
europepmc   +1 more source

Immunoglobulin free light chains and interleukin-6 levels in prediction of kidney injury in patients with multiple myeloma

, 2019
Izeta Aganović-Mušinović, Nešina Avdagić, Nermina Babić, Asja Zaciragic, Orhan Lepara, Jasminko Huskić, Maida Todic-Rakanovic   +6 more
openalex   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source