Results 201 to 210 of about 118,116 (256)

Primary cerebral immunoglobulin light chain amyloidoma in a patient with multiple sclerosis. [PDF]

BMJ Case Rep
Traets MJM, Chuwonpad K, Leguit RJ, Frequin STFM, Minnema MC.   +4 more
europepmc   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Diagnostic performance of liver stiffness as marker of liver involvement in systemic immunoglobulin light chain (AL) amyloidosis. [PDF]

Ann Hematol
Brunger AF, Tingen HSA, Bijzet J, van Rheenen R, Blokzijl H, Roeloffzen WWH, Houwerzijl EJ, Muntinghe FLH, Slart RHJA, Gans ROB, Kimmich C, Hazenberg BPC, Nienhuis HLA.   +12 more
europepmc   +1 more source

Amino-terminal identity of co-existent amyloid and non-amyloid immunoglobulin κ light chain deposits. A human disease to study alterations of protein conformation

, 1997
Batia Kaplan, Rubén Vidal, Ashok Kumar, Jorge Ghiso, Blas Frangione, Gianluca Gallo   +5 more
openalex   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Bioorthogonal Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation

Advanced Science, EarlyView.
Bioorthogonal SDPTAC harnesses US‐responsive Ce6‐TCO and Tz ligands via IEDDA click chemistry to assemble degraders in situ, generating ROS that selectively eliminate nuclear, cytosolic, and membrane proteins, thereby suppressing deep‐seated tumors in vivo.
Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng   +8 more
wiley   +1 more source

Case Report: A missed diagnosis of cardiac amyloidosis using echocardiography due to immunoglobulin light chain amyloidosis with normal wall thickness in the early stage. [PDF]

Front Cardiovasc Med
Li X, Mu T, Deng Y, Zhang Y, Ti Y, Zhang L.   +5 more
europepmc   +1 more source

Biomimetic Adaptive Hydrothermal Balance Fabric‐Based Dual‐Interface Solar Evaporator for Efficient and Stable Desalination

Advanced Science, EarlyView.
This study combines the biological structure of octopuses with the “3D structure” of spacer fabrics to fabricate a dual‐interface solar evaporator with adaptive hydrothermal balance. Water adaptation is achieved through the differentiated design of the upper and lower layers, and dynamic hydrothermal balance is realized by dynamically regulating the ...
Ning Niu, Lingjie Yu, Jiaguang Meng, Wei Fan, Kaili Chen, Wanwan He, Yongzhen Wang, Yaming Liu, Ying Li, Zhaoling Sun, Chao Zhi   +10 more
wiley   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

A Rare Case of Non-IgM Lymphoplasmacytic Lymphoma with Unusual Lack of Immunoglobulin Light Chain Production. [PDF]

Am J Case Rep
Yin J, Bains A, Alsammak M, Fu JJ.
europepmc   +1 more source