Results 41 to 50 of about 394,026 (356)
Hereditary systemic immunoglobulin light-chain amyloidosis [PDF]
, 2015 Several members of a family died from renal failure as a result of systemic amyloidosis. Extensive studies to detect previously documented gene mutations associated with amyloidosis failed to identify a causative factor.
Benson, Merrill D. +2 more
core +1 more source
Haematologica, 2016 Response criteria for multiple myeloma are based upon changes in monoclonal protein levels quantified using serum and/or urine protein electrophoresis.
Thomas Dejoie +4 more
doaj +1 more source
Anais Brasileiros de Dermatologia, 2015 Immunoglobulin light chain amyloidosis is the most common acquired systemic amyloidosis. Its presentation is often insidious and progressive, which may delay diagnosis.
Han MA +4 more
doaj +1 more source
Signaling Pathway for the Development of Pre-B Cells [PDF]
, 2018 Pre-B cells represent the immature stage of the B cell lineage and express genes for the pre-B cell receptor (preBCR). PreBCR consists of lambda 5 and VpreB and its expression elicits a rearrangement of the immunoglobulin heavy chain prior to ...
Tsuruyama, Tatsuaki
core +2 more sources
Biomarkers in Immunoglobulin Light Chain Amyloidosis
Klinicka Onkologie, 2017 Immunoglobulin light chain amyloidosis (AL amyloidosis - ALA) is a monoclonal gammopathy characterized by presence of aberrant plasma cells producing amyloidogenic immunoglobulin light chains. This leads to formation of amyloid fibrils in various organs and tissues, mainly in heart and kidney, and causes their dysfunction.
Kufova, Z. +17 more
openaire +3 more sources
Comparison of Hevylite™ IgA and IgG assay with conventional techniques for the diagnosis and follow-up of plasma cell dyscrasia [PDF]
, 2015 Background: Heavy/light chain assay allows the characterization and quantification of immunoglobulin light chains bound to heavy chains for each Ig’k and Ig’ immunoglobulin class, discriminating between the involved/uninvolved isotypes in plasma cell ...
Caimi, Luigi +6 more
core +1 more source
Two cases of monoclonal nodular pulmonary amyloidosis and review of the literature [PDF]
, 2016 Nodular pulmonary amyloidosis (NPA) is an uncommon pathology of insoluble protein depositing in pulmonary parenchyma. This localized pulmonary form of amyloidosis is most often found to contain combinations of kappa and lambda immunoglobulin light chain ...
Endicott, Kendal +4 more
core +2 more sources
Chimerization of antibodies by isolation of rearranged genomic variable regions by the polymerase chain reaction [PDF]
, 1991 We describe a new method for amplification, by polymerase chain reaction (PCR), of rearranged segments encoding the variable part of light and heavy chains of an antibody (Ab) from the chromosomal DNA of hybridoma cells for the chimerization ofAbs.
Kaluzab, Brigitte +4 more
core +1 more source
Non-functional immunoglobulin G transcripts in a case of hyper-immunoglobulin M syndrome similar to type 4 [PDF]
, 2004 86% of immunoglobulin G (IgG) heavy-chain gene transcripts were found to be non-functional in the peripheral blood B cells of a patient initially diagnosed with common variable immunodeficiency, who later developed raised IgM, whereas no non-functionally
Allen RC +9 more
core +2 more sources
Immunoglobulin Free Light Chain Dimers in Human Diseases
The Scientific World Journal, 2011 Immunoglobulin free light chain (FLC) kappa (κ) and lambda (λ) isotypes exist mainly in monomeric and dimeric forms. Under pathological conditions, the level of FLCs as well as the structure of monomeric and dimeric FLCs and their dimerization properties
Batia Kaplan, Avi Livneh, Ben-Ami Sela
doaj +1 more source