Results 41 to 50 of about 258,635 (326)
Blood, 2017 The goal of this study was to investigate the frequency of use of light-chain variable region (IGVL) genes among patients with systemic (ALS) and localized (ALL) amyloidosis and to assess for associations between IGVL gene usage and organ tropism.
T. Kourelis +9 more
semanticscholar +1 more source
Human Vaccines & Immunotherapeutics, 2019 Deficient antibody production in patients with common variable immunodeficiency (CVID) is accompanied by an inability to produce free light chains (FLCs), particularly kappa (κ) FLC, due to B-cell dysfunction.
Adina Elena Stanciu +2 more
doaj +1 more source
Frontiers in Immunology, 2018 Discussion of the antibody repertoire usually emphasizes diversity, but a conspicuous feature of the light chain repertoire is its lack of diversity. The diversity of reported allelic variants of germline light chain genes is also limited, even in well ...
A. Collins, C. Watson
semanticscholar +1 more source
Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience
Haematologica, 2013 Amyloidosis of the gastrointestinal tract, with biopsy-proven disease, is rare. We reviewed a series of patients who presented with biopsy-proven gastrointestinal amyloidosis and report their clinical characteristics, treatments, and survival.
Andrew J. Cowan +7 more
doaj +1 more source
Haematologica, 2018 A 67-year-old male presented with a one-year history of fatigue, cold intolerance, malaise and an unintentional weight loss of ~80 lbs over the course of the preceding 12 months.
N. Leung, S. Thomé, A. Dispenzieri
semanticscholar +1 more source
Light‐chain amyloid myopathy isolated to skeletal muscles: A case report
Clinical Case Reports, 2020 Isolated amyloidosis, especially of amyloid light‐chain type, is an infrequent disease. Systemic chemotherapy for light‐chain amyloidosis isolated to skeletal muscles plays a key role to reduce clonal plasma cells producing aberrant immunoglobulin.
Toshihiro Matsukawa +5 more
doaj +1 more source
Haematologica, 2018 Systemic AL amyloidosis (AL) is caused by deposition of misfolded immunoglobulin light chains, leading to potentially catastrophic visceral dysfunction.[1][1] Outcomes are heterogeneous, but cardiac involvement is a key survival predictor.
R. Manwani +13 more
semanticscholar +1 more source
Treatment of IgM-associated immunoglobulin light-chain amyloidosis with rituximab-bendamustine.
Blood, 2018 TO THE EDITOR: Systemic amyloid light-chain amyloidosis (AL) is characterized by deposition of misfolded immunoglobulin light chains within organs. AL with an immunoglobulin M (IgM) monoclonal protein (IgM-AL) accounts for 5% to 7% of AL and exhibits ...
R. Manwani +13 more
semanticscholar +1 more source
Immunoglobulin light chains in medaka (Oryzias latipes) [PDF]
Immunogenetics, 2013 The gene segments encoding antibodies have been studied in many capacities and represent some of the best-characterized gene families in traditional animal disease models (mice and humans). To date, multiple immunoglobulin light chain (IgL) isotypes have been found in vertebrates and it is unclear as to which isotypes might be more primordial in nature.
Magadan-Mompo, Susana +3 more
openaire +4 more sources
Blood, 2016 To the editor: Immunoglobulin light chain amyloidosis (AL) with advanced cardiac involvement is characterized by short survival. Outcomes are especially poor for patients who have multiorgan involvement and coexisting multiple myeloma and do not achieve
T. Sher, B. Fenton, A. Akhtar, M. Gertz
semanticscholar +1 more source