Results 41 to 50 of about 455,115 (204)
Human Vaccines & Immunotherapeutics, 2019 Deficient antibody production in patients with common variable immunodeficiency (CVID) is accompanied by an inability to produce free light chains (FLCs), particularly kappa (κ) FLC, due to B-cell dysfunction.
Adina Elena Stanciu +2 more
doaj +1 more source
Blood, 2017 The goal of this study was to investigate the frequency of use of light-chain variable region (IGVL) genes among patients with systemic (ALS) and localized (ALL) amyloidosis and to assess for associations between IGVL gene usage and organ tropism.
T. Kourelis +9 more
semanticscholar +1 more source
Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience
Haematologica, 2013 Amyloidosis of the gastrointestinal tract, with biopsy-proven disease, is rare. We reviewed a series of patients who presented with biopsy-proven gastrointestinal amyloidosis and report their clinical characteristics, treatments, and survival.
Andrew J. Cowan +7 more
doaj +1 more source
Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data [PDF]
Nucleic Acids Research 48 (19) 10702-10712 (2020), 2020 Somatic hypermutations of immunoglobulin (Ig) genes occuring during affinity maturation drive B-cell receptors' ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. However, a rigorous quantification of this bias has been
arxiv +1 more source
Frontiers in Immunology, 2018 Discussion of the antibody repertoire usually emphasizes diversity, but a conspicuous feature of the light chain repertoire is its lack of diversity. The diversity of reported allelic variants of germline light chain genes is also limited, even in well ...
A. Collins, C. Watson
semanticscholar +1 more source
Method for identification of condition-associated public antigen receptor sequences [PDF]
eLife 2018;7:e33050, 2017 Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv +1 more source
Haematologica, 2018 A 67-year-old male presented with a one-year history of fatigue, cold intolerance, malaise and an unintentional weight loss of ~80 lbs over the course of the preceding 12 months.
N. Leung, S. Thomé, A. Dispenzieri
semanticscholar +1 more source
Light‐chain amyloid myopathy isolated to skeletal muscles: A case report
Clinical Case Reports, 2020 Isolated amyloidosis, especially of amyloid light‐chain type, is an infrequent disease. Systemic chemotherapy for light‐chain amyloidosis isolated to skeletal muscles plays a key role to reduce clonal plasma cells producing aberrant immunoglobulin.
Toshihiro Matsukawa +5 more
doaj +1 more source
Haematologica, 2018 Systemic AL amyloidosis (AL) is caused by deposition of misfolded immunoglobulin light chains, leading to potentially catastrophic visceral dysfunction.[1][1] Outcomes are heterogeneous, but cardiac involvement is a key survival predictor.
R. Manwani +13 more
semanticscholar +1 more source
Treatment of IgM-associated immunoglobulin light-chain amyloidosis with rituximab-bendamustine.
Blood, 2018 TO THE EDITOR: Systemic amyloid light-chain amyloidosis (AL) is characterized by deposition of misfolded immunoglobulin light chains within organs. AL with an immunoglobulin M (IgM) monoclonal protein (IgM-AL) accounts for 5% to 7% of AL and exhibits ...
R. Manwani +13 more
semanticscholar +1 more source